The DOI matches its Crossref record; 74 of the 74 references it cites were found in a registry or an index.
Attempted Suicide Characteristics and Cerebrospinal Fluid Amine Metabolites in Depressed Inpatients
Abstract
Background Serotonin abnormalities have been reported in the brain of suicide victims. Evidence of a serotonin deficiency in suicide attempters is less consistent. We hypothesized that a serotonin deficiency may be present in suicide attempters whose attempt behavior more closely approximates completed suicide.Method Sixty-seven (67) drug-free depressed inpatients (46 suicide attempters, 21 nonattempters) underwent research clinical assessments and a lumbar puncture. Cerebrospinal fluid (CSF) monoamine metabolites were assayed. Degree of medical damage and intent of the most recent suicide attempt were rated.Results CSF amine metabolites did not differentiate suicide attempters as a group from nonattempters. However, reduced serotonergic activity, as indicated by lower levels of CSF-5-hydroxyindoleacetic acid (5-HIAA) was associated with a history of planned suicide attempts and with suicide attempts that resulted in greater medical damage. Other monoamine metabolites did not correlate with seriousness of suicidal behavior, except for low CSF homovanillic acid and higher medical damage. No correlation was found with violent method.Conclusions Planned and more medically damaging suicide attempts appear to be associated specifically with low serotonergic activity and, therefore, resemble completed suicide both behaviorally and biochemically. It remains to be determined whether low levels of CSF 5-HIAA can predict greater medical damage in future suicide attempts.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The more medically damaging or potentially lethal but nonfatal suicide attempts show serotonin abnormalities analogous to those found in postmortem examination of brain tissue from people who died by suicide (26).”
From The Columbia–Suicide Severity Rating Scale: Initial Validity and Internal Consistency Findings From Three Multisite Studies With Adolescents and Adults (2011) · cites this paper as [26]
Citations
Cites
Hamilton, M. (1960) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.23.1.56 · Cited by 32,817
5-HIAA in the Cerebrospinal Fluid
Åsberg, M. (1976) · Archives of General Psychiatry · doi:10.1001/archpsyc.1976.01770100055005 · Cited by 1,455
Ostwald, P. F. (1960) · American Journal of Psychotherapy · doi:10.1176/appi.psychotherapy.1960.14.4.817 · Cited by 1,422
Linnoila, M., Virkkunen, M., Scheinin, M., Nuutila, A., Rimon, R., & Goodwin, F. K. (1983) · Life Sciences · doi:10.1016/0024-3205(83)90344-2 · Cited by 1,308
Aggression in humans correlates with cerebrospinal fluid amine metabolites
Brown, G. L., Goodwin, F. K., Ballenger, J. C., Goyer, P. F., & Major, L. F. (1979) · Psychiatry Research · doi:10.1016/0165-1781(79)90053-2 · Cited by 1,138
Aggression, suicide, and serotonin: relationships to CSF amine metabolites
Brown, G. L., Ebert, M. H., Goyer, P. F., Jimerson, D. C., Klein, W. J., Bunney, W. E., & Goodwin, F. K. (1982) · American Journal of Psychiatry · doi:10.1176/ajp.139.6.741 · Cited by 908
Development of suicidal intent scales.
Beck, A. T., Schuyler, D., & Herman, I. (1974) · Cited by 710
Monoamine Metabolites in CSF and Suicidal Behavior
Träskman, L. (1981) · Archives of General Psychiatry · doi:10.1001/archpsyc.1981.01780310031002 · Cited by 692
"Serotonin Depression"—A Biochemical Subgroup Within the Affective Disorders?
Åsberg, M., Thorén, P., Traskman, L., Bertilsson, L., & Ringberger, V. (1976) · Science · doi:10.1126/science.1246632 · Cited by 682
(1956) · BMJ · doi:10.1136/bmj.2.4996.813 · Cited by 640
Cited by
Sorted by citations
Posner, K., Brown, G. K., Stanley, B., Brent, D. A., Yershova, K. V., Oquendo, M. A., Currier, G. W., Melvin, G. A., Greenhill, L., Shen, S., et al. (2011) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2011.10111704 · Cited by 5,157
“The more medically damaging or potentially lethal but nonfatal suicide attempts show serotonin abnormalities analogous to those found in postmortem examination of brain tissue from people who died by suicide (26).”
BackgroundSelf-citationToward a clinical model of suicidal behavior in psychiatric patients
Mann, J. J., Waternaux, C., Haas, G. L., & Malone, K. M. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.2.181 · Cited by 1,791
Self-citationNeurocircuitry of Mood Disorders
Price, J. L., & Drevets, W. C. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.104 · Cited by 1,606
Neurobiology of suicidal behaviour
Mann, J. J. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1220 · Cited by 1,260
Self-citationBrezo, J., Paris, J., & Turecki, G. (2006) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2005.00702.x · Cited by 647
Metadata
- Authors
- Mann, J.
- Affiliations
- Columbia University (US)
- Corresponding author
- Mann, J
- Venue
- Neuropsychopharmacology
- Published
- 1996-12
- Volume
- 15
- Issue
- 6
- Pages
- 576-586
- ISSN
- 0893-133X (ISSN-L)
- OpenAlex
- W1990830006
- Cited by
- 178
- References
- 74
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 3 · 2022: 2 · 2021: 7 · 2020: 5 · 2018: 3 · 2017: 3 · 2016: 7 · 2015: 6 · 2014: 9 · 2013: 9 · 2012: 7
- FWCI
- 8.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuropsychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (1r01mh040048-01)
- National Institute of Mental Health (MH-40048, MH48514, MH46745, R01MH048514)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Keywords
- suicide attempts, depression, cerebrospinal fluid, serotonin, 5-hydroxyindoleacetic acid, monoamine metabolites, homovanillic acid, suicidal intent, suicide mortality, suicide risk prediction
- MeSH terms
- Adult, Aged, Chromatography, High Pressure Liquid, Depressive Disorder, Female, Homovanillic Acid, Humans, Hydroxyindoleacetic Acid, Inpatients, Male, Methoxyhydroxyphenylglycol, Middle Aged, Severity of Illness Index, Suicide, Attempted
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
