Cited by 178Suicide and Self-Harm StudiesNeurotransmitter Receptor Influence on BehaviorTreatment of Major Depression

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Attempted Suicide Characteristics and Cerebrospinal Fluid Amine Metabolites in Depressed Inpatients

Mann, J·1996·Neuropsychopharmacology

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Abstract

Background Serotonin abnormalities have been reported in the brain of suicide victims. Evidence of a serotonin deficiency in suicide attempters is less consistent. We hypothesized that a serotonin deficiency may be present in suicide attempters whose attempt behavior more closely approximates completed suicide.Method Sixty-seven (67) drug-free depressed inpatients (46 suicide attempters, 21 nonattempters) underwent research clinical assessments and a lumbar puncture. Cerebrospinal fluid (CSF) monoamine metabolites were assayed. Degree of medical damage and intent of the most recent suicide attempt were rated.Results CSF amine metabolites did not differentiate suicide attempters as a group from nonattempters. However, reduced serotonergic activity, as indicated by lower levels of CSF-5-hydroxyindoleacetic acid (5-HIAA) was associated with a history of planned suicide attempts and with suicide attempts that resulted in greater medical damage. Other monoamine metabolites did not correlate with seriousness of suicidal behavior, except for low CSF homovanillic acid and higher medical damage. No correlation was found with violent method.Conclusions Planned and more medically damaging suicide attempts appear to be associated specifically with low serotonergic activity and, therefore, resemble completed suicide both behaviorally and biochemically. It remains to be determined whether low levels of CSF 5-HIAA can predict greater medical damage in future suicide attempts.

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Authors: Mann, J.
Affiliations: Columbia University (US)
Corresponding author: Mann, J
Venue: Neuropsychopharmacology
Publisher: Springer Science and Business Media LLC
Published: 1996-12
Volume: 15
Issue: 6
Pages: 576-586
ISSN: 0893-133X (ISSN-L)
DOI: 10.1016/s0893-133x(96)00102-9
OpenAlex: W1990830006
Cited by: 178
References: 74
Citations by year: 2026: 1 · 2025: 2 · 2024: 2 · 2023: 3 · 2022: 2 · 2021: 7 · 2020: 5 · 2018: 3 · 2017: 3 · 2016: 7 · 2015: 6 · 2014: 9 · 2013: 9 · 2012: 7
FWCI: 8.42
Type: journal article
Language: en
Open access: closed
Locations: Neuropsychopharmacology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (1r01mh040048-01)
National Institute of Mental Health (MH-40048, MH48514, MH46745, R01MH048514)
Topics: Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Keywords: suicide attempts, depression, cerebrospinal fluid, serotonin, 5-hydroxyindoleacetic acid, monoamine metabolites, homovanillic acid, suicidal intent, suicide mortality, suicide risk prediction
MeSH terms: Adult, Aged, Chromatography, High Pressure Liquid, Depressive Disorder, Female, Homovanillic Acid, Humans, Hydroxyindoleacetic Acid, Inpatients, Male, Methoxyhydroxyphenylglycol, Middle Aged, Severity of Illness Index, Suicide, Attempted

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Attempted Suicide Characteristics and Cerebrospinal Fluid Amine Metabolites in Depressed Inpatients

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