Cited by 374Psychedelics and Drug StudiesNeurotransmitter Receptor Influence on BehaviorHallucinations in medical conditions

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Serotonin and Hallucinogens

Aghajanian, G·1999·Neuropsychopharmacology

DOI 10.1016/s0893-133x(98)00135-3

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Abstract

This brief review traces the serotonin (5-HT) hypothesis of the action of hallucinogenic drugs from the early 1950s to the present day. There is now converging evidence from biochemical, electrophysiological, and behavioral studies that the two major classes of psychedelic hallucinogens, the indoleamines (e.g., LSD) and the phenethylamines (e.g., mescaline), have a common site of action as partial agonists at 5-HT2A and other 5-HT2 receptors in the central nervous system. The noradrenergic locus coeruleus and the cerebral cortex are among the regions where hallucinogens have prominent effects through their actions upon a 5-HT2A receptors. Recently, we have observed a novel effect of hallucinogens--a 5-HT2A receptor-mediated enhancement of nonsynchronous, late components of glutamatergic excitatory postsynaptic potentials at apical dendrites of layer V cortical pyramidal cells. We propose that an effect of hallucinogens upon glutamatergic transmission in the cerebral cortex may be responsible for the higher-level cognitive, perceptual, and affective distortions produced by these drugs.

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EVIDENCE FOR THE EXISTENCE OF MONOAMINE-CONTAINING NEURONS IN THE CENTRAL NERVOUS SYSTEM. I. DEMONSTRATION OF MONOAMINES IN THE CELL BODIES OF BRAIN STEM NEURONS.
Dahlstroem, A., & Fuxé, K. (1964) · PubMed · Cited by 5,133
International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (Serotonin).
Hoyer, D., Clarke, D. E., Fozard, J. R., Hartig, P. R., Martin, G. R., Mylecharane, E. J., Saxena, P. R., & Humphrey, P. P. A. (1994) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06783-3 · Cited by 3,025
Quantitative autoradiographic mapping of serotonin receptors in the rat brain. I. Serotonin-1 receptors
Pazos, Á., & Palacios, J. M. (1985) · Brain Research · doi:10.1016/0006-8993(85)90856-x · Cited by 1,855
Nonrepinephrine-containing locus coeruleus neurons in behaving rats exhibit pronounced responses to non-noxious environmental stimuli
Aston‐Jones, G., & Bloom, F. E. (1981) · Journal of Neuroscience · doi:10.1523/jneurosci.01-08-00887.1981 · Cited by 1,072
Evidence for 5-HT2 involvement in the mechanism of action of hallucinogenic agents
Glennon, R. A., Titeler, M., & MCKENNEY, J. D. J. (1984) · Life Sciences · doi:10.1016/0024-3205(84)90436-3 · Cited by 635
5-Hydroxytryptamine2 and 5-hydroxytryptamine1A receptors mediate opposing responses on membrane excitability in rat association cortex
Araneda, R. C., & Andrade, R. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90128-b · Cited by 621
A BIOCHEMICAL AND PHARMACOLOGICAL SUGGESTION ABOUT CERTAIN MENTAL DISORDERS
Woolley, D. W., & Shaw, E. (1954) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.40.4.228 · Cited by 603
SERUM VASOCONSTRICTOR (SEROTONIN)
Rapport, M. M., Green, A. A., & Page, I. H. (1948) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)57137-4 · Cited by 552
5-Hydroxytryptamine 2A serotonin receptors in the primate cerebral cortex: Possible site of action of hallucinogenic and antipsychotic drugs in pyramidal cell apical dendrites
Jakab, R. L., & Goldman-Rakic, P. S. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.2.735 · Cited by 536
Serotonin Content of Some Mammalian Tissues and Urine and a Method for Its Determination
Twarog, B. M., & Page, I. H. (1953) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1953.175.1.157 · Cited by 532

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5-HT2A and 5-HT2C receptor stimulation are differentially involved in the cortical dopamine efflux—Studied in 5-HT2A and 5-HT2C genetic mutant mice
Huang, M., Dai, J., & Meltzer, H. Y. (2010) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2010.10.094 · Cited by 25
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Giovanni, G. D., & Deurwaerdère, P. D. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.10.004 · Cited by 25
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Olajossy-Hilkesberger, L., Godlewska, B. R., Schosser, A., Olajossy, M., Wojcierowski, J., Landowski, J., Marmurowska-Michałowska, H., & Kasper, S. F. (2011) · Neuropsychobiology · doi:10.1159/000327602 · Cited by 24
Large-scale brain networks and Freudian ego
Dimkov, P. R. (2019) · Psychological Thought · doi:10.5964/psyct.v12i2.328 · Cited by 23
Pupal emergence pattern in cactophilic Drosophila and the effect of host plants
Soto, E. M., Padró, J., Carmona, P. S. M., Tuero, D. T., Carreira, V. P., & Soto, I. M. (2017) · Insect Science · doi:10.1111/1744-7917.12484 · Cited by 23
Generation of neural cells using iPSCs from sleep bruxism patients with 5-HT2A polymorphism.
Hoashi, Y., Okamoto, S., Abe, Y., Matsumoto, T., Tanaka, J., Yoshida, Y., Imaizumi, K., Mishima, K., Akamatsu, W., Okano, H., et al. (2017) · Journal of Prosthodontic Research · doi:10.1016/j.jpor.2016.11.003 · Cited by 20
Chronic fluoxetine upregulates arachidonic acid incorporation into the brain of unanesthetized rats
Qu, Y., Chang, L., Klaff, J., Seemann, R., GREENSTEIN, D. K., & Rapoport, S. I. (2006) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2006.01.008 · Cited by 23
Translocation of the 5-alkoxy substituent of 2,5-dialkoxyarylalkylamines to the 6-position: effects on 5-HT2A/2C receptor affinity
Chambers, J. J., Kurrasch‐Orbaugh, D. M., & Nichols, D. E. (2002) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/s0960-894x(02)00306-2 · Cited by 23
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DMT at fifty.
Szara, S. I. (2007) · PubMed · Cited by 22
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Authors: Aghajanian, G.
Affiliations: Yale University (US)
Corresponding author: Aghajanian, G
Venue: Neuropsychopharmacology
Publisher: Springer Science and Business Media LLC
Published: 1999-08
Volume: 21
Issue: 2
Pages: 16S-23S
ISSN: 0893-133X (ISSN-L)
DOI: 10.1016/s0893-133x(98)00135-3
OpenAlex: W2075352853
Cited by: 371
References: 45
Citations by year: 2026: 8 · 2025: 5 · 2024: 6 · 2023: 11 · 2022: 13 · 2021: 11 · 2020: 9 · 2019: 10 · 2018: 18 · 2017: 17 · 2016: 15 · 2015: 13 · 2014: 12 · 2013: 14 · 2012: 8
FWCI: 3.97
Type: journal article
Language: en
Open access: closed
Locations: Neuropsychopharmacology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Mental Health
Topics: Social Sciences › Psychology › Clinical Psychology › Psychedelics and Drug Studies
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Hallucinations in medical conditions
Keywords: serotonin, hallucinogens, 5-HT2A receptor, psychedelics, indoleamines, phenethylamines, LSD, mescaline, locus coeruleus, cerebral cortex, glutamatergic neurotransmission, excitatory postsynaptic potentials, cortical pyramidal neurons
MeSH terms: Animals, Cerebral Cortex, Hallucinogens, Humans, Synaptic Transmission, Receptors, Serotonin, Serotonin, Pyramidal Cells, Receptor, Serotonin, 5-HT2A

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