Behavioral changes and [123I]IBZM equilibrium SPECT measurement of amphetamine-induced dopamine release in rhesus monkeys exposed to subchronic amphetamine
Abstract
Previously we have shown that twelve weeks of repeated low-dose d-amphetamine (AMPH) exposure in rhesus monkeys induces a long-lasting enhancement of behavioral responses to acute low-dose challenge. The present study was designed to investigate the behavioral and neurochemical consequences of a six-week regimen of low-dose AMPH exposure (0.1-1.0 mg/kg, i.m., b.i.d.) in rhesus monkeys. SPECT imaging of AMPH's (0.4 mg/kg) ability to displace [123I]IBZM bound to D2 dopamine receptors in the striatum of saline control and AMPH-treated animals prior to and following chronic treatment was accomplished using a bolus/constant infusion paradigm. Following chronic AMPH treatment, all monkeys showed an enhanced behavioral response to acute AMPH challenge and a significant decrease in the percent of AMPH-induced displacement of [123I]IBZM in striatum compared to their pretreatment scans. These findings suggest that relatively small changes in presynaptic dopamine function may be reflected in significant alterations in the behavioral response to acute AMPH challenge.
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Dopamine levels are decreased in animals chronically exposed to drugs of abuse.
“Dopamine levels are decreased in animals chronically exposed to drugs of abuse (Castner et al., 2000; Kirkland Henry et al., 2009; Lee et al., 2011; Maisonneuve et al., 1995; Melega et al., 2008; Segal and Kuczenski, 1992; Sorg et al., 1997).”
From Imaging addiction: D2 receptors and dopamine signaling in the striatum as biomarkers for impulsivity (2014) · cites this paper as Castner et al., 2000
Cites
Robinson, T. G., & BECKER, J. (1986) · Brain Research · doi:10.1016/s0006-8993(86)80193-7 · Cited by 2,110 · see citing works
Kalivas, P. W., & Stewart, J. (1991) · Brain Research Reviews · doi:10.1016/0165-0173(91)90007-u · Cited by 2,021 · see citing works
Robinson, T. E., & Becker, J. B. (1986) · Brain Research Reviews · doi:10.1016/0165-0173(86)90002-0 · Cited by 1,796 · see citing works
Molecular and Cellular Basis of Addiction
Nestler, E. J., & Aghajanian, G. K. (1997) · Science · doi:10.1126/science.278.5335.58 · Cited by 1,315 · see citing works
Laruelle, M., Abi-Dargham, A., van Dyck, C. H., Gil, R., D'Souza, C. D., Erdos, J., McCance, E., Rosenblatt, W., Fingado, C., Zoghbi, S. S., et al. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.17.9235 · Cited by 1,291 · see citing works
Breier, A., Su, T.-P., Saunders, R., Carson, R. E., Kolachana, B. S., de Bartolomeis, A., Weinberger, D. R., Weisenfeld, N., Malhotra, A. K., Eckelman, W. C., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.6.2569 · Cited by 1,154 · cited 2× · see citing works
“Moreover, this interpretation could help to explain the differences between the findings in the present experiment for sensitized monkeys and those previously reported for schizophrenics (Abi-Dargham et al. 1998; Laruelle et al. 1996; Breier et al. 1997).”
BackgroundResultIncreased striatal dopamine transmission in schizophrenia: confirmation in a second cohort.
Abi-Dargham, A., Gil, R. B., Krystal, J., Baldwin, R., Seibyl, J., Bowers, M., van Dyck, C., Charney, D., Innis, R., & Laruelle, M. (1998) · American Journal of Psychiatry · doi:10.1176/ajp.155.6.761 · Cited by 860 · see citing works
Decreased striatal dopaminergic responsiveness in detoxified cocaine-dependent subjects
Volkow, N. D., Wang, G.-J., Fowler, J. S., Logan, J., Gatley, S. J., Hitzemann, R., Chen, A. D., Dewey, S. L., & Pappas, N. (1997) · Nature · doi:10.1038/386830a0 · Cited by 854 · see citing works
Terwilliger, R. Z., Beitner‐Johnson, D., Sevarino, K. A., Crain, S. M., & Nestler, E. J. (1991) · Brain Research · doi:10.1016/0006-8993(91)91111-d · Cited by 534 · see citing works
Widespread origin of the primate mesofrontal dopamine system.
Williams, S. M., & Goldman-Rakic, P. (1998) · Cerebral Cortex · doi:10.1093/cercor/8.4.321 · Cited by 481 · see citing works
Paulson, P. E., Camp, D. M., & Robinson, T. E. (1991) · Psychopharmacology · doi:10.1007/bf02244248 · Cited by 455 · see citing works
Kuczenski, R. T., & Segal, D. (1989) · Journal of Neuroscience · doi:10.1523/jneurosci.09-06-02051.1989 · Cited by 398 · see citing works
Ellison, G. D., Eison, M. S., Huberman, H. S., & Daniel, F. (1978) · Science · doi:10.1126/science.26975 · Cited by 312 · see citing works
Kuczenski, R. T., Segal, D., & Aizenstein, M. L. (1991) · Journal of Neuroscience · doi:10.1523/jneurosci.11-09-02703.1991 · Cited by 285 · see citing works
Duman, R. S., Tallman, J. F., & Nestler, E. J. (1988) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)22179-6 · Cited by 282 · see citing works
Microdialysis and SPECT measurements of amphetamine-induced dopamine release in nonhuman primates
Laruelle, M. A., Iyer, R. N., Al‐Tikriti, M. S., Zea‐Ponce, Y., Malison, R. T., Zoghbi, S. S., Baldwin, R. M., Kung, H. F., Charney, D. S., Hoffer, P. B., et al. (1997) · Synapse · doi:10.1002/(sici)1098-2396(199701)25:1 · Cited by 264 · see citing works
Villemagne, V. L., Yuan, J., Wong, D. F., Dannals, R. F., Hatzidimitriou, G., Mathews, W. B., Ravert, H. T., Musachio, J. L., McCann, U. D., & Ricaurte, G. A. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-01-00419.1998 · Cited by 211 · see citing works
Castner, S. (1999) · Neuropsychopharmacology · doi:10.1016/s0893-133x(98)00050-5 · Cited by 187 · see citing works
Self-citationCellular responses to chronic treatment with drugs of abuse.
Nestler, E. J. (1993) · PubMed · Cited by 140 · see citing works
Proakis, A. G., & Harris, G. B. (1978) · Anesthesiology · doi:10.1097/00000542-197805000-00007 · Cited by 130 · see citing works
Melega, W. P., Raleigh, M. J., Stout, D. B., Laćan, G., Huang, S.-C., & Phelps, M. E. (1997) · Brain Research · doi:10.1016/s0006-8993(97)00548-9 · Cited by 126 · see citing works
Behavioral sensitization to cocaine: modulation by the cyclic AMP system in the nucleus accumbens
Miserendino, M. J. D., & Nestler, E. J. (1995) · Brain Research · doi:10.1016/0006-8993(95)00030-t · Cited by 118 · see citing works
Laruelle, M. A., Abi‐Dargham, A., AI-Tikriti, M. S., et al. (1994) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1994.56 · Cited by 102 · see citing works
Brain perfusion SPECT using an annular single crystal camera: initial clinical experience.
Holman, B. L., Pa, C., Zimmerman, R. E., Johnson, K. A., Tumeh, S. S., Ap, S., & Genna, S. (1990) · PubMed · Cited by 75 · see citing works
Bickerdike, M. J., & Abercrombie, E. D. (1997) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)36845-4 · Cited by 42 · see citing works
Kung, M., & Kung, H. F. (1989) · Journal of Labelled Compounds and Radiopharmaceuticals · doi:10.1002/jlcr.2580270612 · Cited by 38 · see citing works
Laruelle, M., Al‐Tikriti, M. S., Zea‐Ponce, Y., et al. (1994) · European Journal of Pharmacology · doi:10.1016/0014-2999(94)90521-5 · Cited by 35 · see citing works
In vivo measures of monoamines during amphetamine-induced behaviors in rats
Kuczenski, R. T., & Segal, D. S. (1990) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/0278-5846(90)90085-u · Cited by 34 · see citing works
Ellison, G. D., & Ratan, R. (1982) · Life Sciences · doi:10.1016/0024-3205(82)90703-2 · Cited by 24 · see citing works
Abercrombie, E. D., & Bickerdike, M. J. (1997) · Schizophrenia Research · doi:10.1016/s0920-9964(97)82197-4 · Cited by 16 · see citing works
Behavioural and biochemical effects of chronic treatment with amphetamine in the vervet monkey
Ridley, R. M., Baker, H. F., Owen, F., et al. (1983) · Neuropharmacology · doi:10.1016/0028-3908(83)90178-8 · Cited by 15 · see citing works
Baldwin, R. M., Zea‐Ponce, Y., Zoghbi, S. S., Al‐Tikriti, M. S., Seibyl, J. P., Sybirska, E. H., Malison, R. T., Laruelle, M. A., Charney, D. S., Hoffer, P. B., et al. (1994) · Nuclear Medicine and Biology · doi:10.1016/0969-8051(94)90087-6 · Cited by 10 · see citing works
Proakis, A. G., & Harris, G. B. (1979) · Survey of Anesthesiology · doi:10.1097/00132586-197906000-00020 · Cited by 5 · see citing works
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Imaging addiction: D2 receptors and dopamine signaling in the striatum as biomarkers for impulsivity
Trifilieff, P., & Martinez, D. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.06.031 · Cited by 171 · see citing works
Cortical Cholinergic Transmission and Cortical Information Processing in Schizophrenia
Sarter, M. (2005) · Schizophrenia Bulletin · doi:10.1093/schbul/sbi006 · Cited by 153 · see citing works
Conditioned and sensitized responses to stimulant drugs in humans
Leyton, M. (2007) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2007.08.027 · Cited by 127 · see citing works
- Authors
- Castner, S.
- Affiliations
- Yale University (US)
- Corresponding author
- Castner, S
- Venue
- Neuropsychopharmacology
- Published
- 2000-01
- Volume
- 22
- Issue
- 1
- Pages
- 4-13
- ISSN
- 0893-133X (ISSN-L)
- OpenAlex
- W1975995220
- Cited by
- 54
- References
- 33
- Citations by year
- 2023: 1 · 2022: 2 · 2020: 2 · 2018: 2 · 2016: 1 · 2015: 3 · 2014: 7 · 2013: 2 · 2012: 2
- FWCI
- 1.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuropsychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (MH 44866, P50MH044866)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Keywords
- amphetamine, dopamine release, dopamine D2 receptor, [123I]IBZM, striatum, SPECT imaging, behavioral sensitization, rhesus monkeys
- MeSH terms
- Animals, Benzamides, Cerebellum, Corpus Striatum, Dextroamphetamine, Dopamine, Drug Administration Schedule, Female, Injections, Intravenous, Iodine Radioisotopes, Macaca mulatta, Male, Motor Activity, Pyrrolidines, Stereotyped Behavior, Tomography, Emission-Computed, Single-Photon, Receptors, Dopamine D2, Dopamine Antagonists
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