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Impact of diabetes on cognitive function among older Latinos
Abstract
Background and objectives Type 2 diabetes, which is highly prevalent in older Mexican Americans, may influence cognitive functioning. We examined the association of diabetes with decline in global cognitive function and memory function over a 2-year period.Methods Study subjects were derived from an existing cohort of Latinos aged 60 and over in the SALSA project (n=1,789). Statistical analysis was conducted using logistic regression and a generalized estimating equation (GEE).Results Logistic regression analysis indicated that baseline diabetes was a significant predictor of major cognitive impairment in Modified Mini Mental State Exam (3MSE) (OR=1.68, 95% CI=1.21, 2.34) and word-list test (OR=1.31, 95% CI=0.99, 1.75). GEE analysis showed that there was no significant difference between diabetic and nondiabetic subjects in change of cognitive scores over 2 years (3MSE, mean=-0.58, 95% CI=-1.48, 0.32; word-list test, mean=-0.10, 95% CI=-0.32, 0.11).Conclusions More diabetic complications were associated with major cognitive decline among diabetic subjects. Research on long-term impact of treatment for type 2 diabetes is warranted.
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Metadata
- Authors
- Wu, J. H., Haan, M. N., Liang, J., Ghosh, D., Gonzalez, H. M., & Herman, W. H.
- Affiliations
- University of Michigan (US)
- Corresponding author
- Haan, Mary N
- Venue
- Journal of Clinical Epidemiology
- Publisher
- Elsevier BV
- Published
- 2003-07
- Volume
- 56
- Issue
- 7
- Pages
- 686-693
- ISSN
- 0895-4356 (ISSN-L)
- OpenAlex
- W2068329087
- Cited by
- 104
- References
- 43
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 2 · 2021: 4 · 2020: 3 · 2019: 5 · 2018: 5 · 2017: 3 · 2016: 6 · 2015: 10 · 2014: 5 · 2013: 3 · 2012: 7
- FWCI
- 4.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Clinical Epidemiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Public Health Service (12975)
- National Institute on Aging (R01AG012975, R03AG033751)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK060753)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Oncology › Cancer-related cognitive impairment studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Keywords
- type 2 diabetes, cognitive decline, cognitive impairment, memory function, Latino older adults, Mexican Americans, aging, diabetes complications
- MeSH terms
- Aged, Aged, 80 and over, California, Cognition Disorders, Diabetes Mellitus, Type 2, Female, Hispanic or Latino, Humans, Longitudinal Studies, Male, Middle Aged, Psychiatric Status Rating Scales, Mental Recall, Risk Factors, Logistic Models, Stroke
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