Cited by 104Dementia and Cognitive Impairment ResearchCancer-related cognitive impairment studiesDiabetes Treatment and Management

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Impact of diabetes on cognitive function among older Latinos

Wu, Jasmanda H, Haan, Mary N, Liang, Jersey, Ghosh, Debashis, Gonzalez, Hector M, Herman, William H·2003·Journal of Clinical Epidemiology

DOI 10.1016/s0895-4356(03)00077-5

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Abstract

Background and objectives Type 2 diabetes, which is highly prevalent in older Mexican Americans, may influence cognitive functioning. We examined the association of diabetes with decline in global cognitive function and memory function over a 2-year period.Methods Study subjects were derived from an existing cohort of Latinos aged 60 and over in the SALSA project (n=1,789). Statistical analysis was conducted using logistic regression and a generalized estimating equation (GEE).Results Logistic regression analysis indicated that baseline diabetes was a significant predictor of major cognitive impairment in Modified Mini Mental State Exam (3MSE) (OR=1.68, 95% CI=1.21, 2.34) and word-list test (OR=1.31, 95% CI=0.99, 1.75). GEE analysis showed that there was no significant difference between diabetic and nondiabetic subjects in change of cognitive scores over 2 years (3MSE, mean=-0.58, 95% CI=-1.48, 0.32; word-list test, mean=-0.10, 95% CI=-0.32, 0.11).Conclusions More diabetic complications were associated with major cognitive decline among diabetic subjects. Research on long-term impact of treatment for type 2 diabetes is warranted.

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Authors: Wu, J. H., Haan, M. N., Liang, J., Ghosh, D., Gonzalez, H. M., & Herman, W. H.
Affiliations: University of Michigan (US)
Corresponding author: Haan, Mary N
ORCID: Wu, Jasmanda H
Haan, Mary N
Liang, Jersey
Ghosh, Debashis
Herman, William H
Venue: Journal of Clinical Epidemiology
Publisher: Elsevier BV
Published: 2003-07
Volume: 56
Issue: 7
Pages: 686-693
ISSN: 0895-4356 (ISSN-L)
DOI: 10.1016/s0895-4356(03)00077-5
OpenAlex: W2068329087
Cited by: 104
References: 43
Citations by year: 2026: 1 · 2024: 1 · 2023: 2 · 2021: 4 · 2020: 3 · 2019: 5 · 2018: 5 · 2017: 3 · 2016: 6 · 2015: 10 · 2014: 5 · 2013: 3 · 2012: 7
FWCI: 4.08
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of Clinical Epidemiology (publishedVersion)
PubMed (publishedVersion)
Funders: U.S. Public Health Service (12975)
National Institute on Aging (R01AG012975, R03AG033751)
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK060753)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Health Sciences › Medicine › Oncology › Cancer-related cognitive impairment studies
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Keywords: type 2 diabetes, cognitive decline, cognitive impairment, memory function, Latino older adults, Mexican Americans, aging, diabetes complications
MeSH terms: Aged, Aged, 80 and over, California, Cognition Disorders, Diabetes Mellitus, Type 2, Female, Hispanic or Latino, Humans, Longitudinal Studies, Male, Middle Aged, Psychiatric Status Rating Scales, Mental Recall, Risk Factors, Logistic Models, Stroke

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Impact of diabetes on cognitive function among older Latinos

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