Underpowering in randomized trials reporting a sample size calculation

The Revised CONSORT Statement for Reporting Randomized Trials: Explanation and Elaboration

Altman, D. G., Schulz, K. F., Moher, D., Egger, M., Davidoff, F., Elbourne, D., Gøtzsche, P. C., Lang, T., & for the CONSORT Group (2001) · Annals of Internal Medicine · doi:10.7326/0003-4819-134-8-200104170-00012 · Cited by 3,835 · see citing works

The Importance of Beta, the Type II Error and Sample Size in the Design and Interpretation of the Randomized Control Trial: Survey of 71 Negative Trials

Freiman, J. A., Chalmers, T. C., Smith, H., & Kuebler, R. R. (1978) · New England Journal of Medicine · doi:10.1056/nejm197809282991304 · Cited by 1,628 · see citing works

On the use of a pilot sample for sample size determination

Browne, R. H. (1995) · Statistics in Medicine · doi:10.1002/sim.4780141709 · Cited by 1,007 · see citing works

Statistical Power, Sample Size, and Their Reporting in Randomized Controlled Trials

Moher, D. (1994) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1994.03520020048013 · Cited by 608 · see citing works

Randomised controlled trial of non-directive counselling, cognitive-behaviour therapy, and usual general practitioner care for patients with depression. II: Cost effectiveness

Bower, P., Byford, S., Sibbald, B., Ward, E. S., King, M., Lloyd, M., & Gabbay, M. (2000) · BMJ · doi:10.1136/bmj.321.7273.1389 · Cited by 346 · see citing works

Randomised trial of acupuncture compared with conventional massage and “sham” laser acupuncture for treatment of chronic neck painCommentary: Controls for acupuncture—can we finally see the light?

Irnich, D., Cummings, M., Behrens, N., Molzen, H., König, A., Gleditsch, J., Krauss, M., Natalis, M., Senn, E., Beyer, A., et al. (2001) · BMJ · doi:10.1136/bmj.322.7302.1574 · Cited by 313 · see citing works

Randomised controlled trial of non-directive counselling, cognitive-behaviour therapy, and usual general practitioner care for patients with depression. I: Clinical effectiveness

Ward, E. S., King, M., Lloyd, M., Bower, P., Sibbald, B., Farrelly, S., Gabbay, M., Tarrier, N., & Addington-Hall, J. M. (2000) · BMJ · doi:10.1136/bmj.321.7273.1383 · Cited by 271 · see citing works

Randomised controlled trial comparing hospital at home care with inpatient hospital care. I: three month follow up of health outcomes

Shepperd, S., Harwood, D., Jenkinson, C., Gray, A. M., Vessey, M. P., & Morgan, P. (1998) · BMJ · doi:10.1136/bmj.316.7147.1786 · Cited by 221 · see citing works

Compliance, satisfaction, and quality of life of patients with colorectal cancer receiving home chemotherapy or outpatient treatment: a randomised controlled trial

Borràs, J. M., Sanchez-Hernandez, A., Navarro, M., Martinez, M., Mendez, E., Ponton, J. L. L., Espinas, J. A., & Germa, J. R. (2001) · BMJ · doi:10.1136/bmj.322.7290.826 · Cited by 155 · see citing works

A comparison of handsearching versus MEDLINE searching to identify reports of randomized controlled trials

Hopewell, S., Clarke, M., Lusher, A., Lefebvre, C., & Westby, M. (2002) · Statistics in Medicine · doi:10.1002/sim.1191 · Cited by 116 · see citing works

Sample size re‐estimation: recent developments and practical considerations

Gould, A. L. (2001) · Statistics in Medicine · doi:10.1002/sim.733 · Cited by 115 · see citing works

Type-II Error Rates (Beta Errors) of Randomized Trials in Orthopaedic Trauma

Lochner, H. V., Bhandari, M., & Tornetta, P. (2001) · Journal of Bone and Joint Surgery · doi:10.2106/00004623-200111000-00005 · Cited by 113 · see citing works

Low power, type II errors, and other statistical problems in recent cardiovascular research

Williams, J. L., Hathaway, C. A., Kloster, K. L., & Layne, B. H. (1997) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1997.273.1.h487 · Cited by 85 · see citing works

Have Randomized Controlled Trials of Neuroprotective Drugs Been Underpowered?: An Illustration of Three Statistical Principles

Samsa, G. P., & Matchar, D. B. (2001) · Stroke · doi:10.1161/01.str.32.3.669 · Cited by 51 · see citing works

Beta, or type II error in psychiatric controlled clinical trials

Edlund, M. J., Overall, J. E., & Rhoades, H. M. (1985) · Journal of Psychiatric Research · doi:10.1016/0022-3956(85)90074-3 · Cited by 21 · see citing works

The power of tests to detect differences between periodontal treatments in published studies

Hujoel, P. P., Baab, D. A., & DeRouen, T. A. (1992) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.1992.tb02170.x · Cited by 14 · see citing works

SPIRIT 2013 explanation and elaboration: guidance for protocols of clinical trials

Chan, A.-W., Tetzlaff, J. M., Gotzsche, P. C., Altman, D. G., Mann, H., Berlin, J. A., Dickersin, K., Hrobjartsson, A., Schulz, K. F., Parulekar, W. R., et al. (2013) · BMJ · doi:10.1136/bmj.e7586 · Cited by 6,251 · see citing works

Considerations in determining sample size for pilot studies

Hertzog, M. A. (2008) · Research in Nursing & Health · doi:10.1002/nur.20247 · Cited by 2,337 · see citing works

The size of a pilot study for a clinical trial should be calculated in relation to considerations of precision and efficiency

Sim, J., & Lewis, M. (2012) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2011.07.011 · Cited by 1,036 · see citing works

Sample size requirements to estimate key design parameters from external pilot randomised controlled trials: a simulation study

Teare, M. D., Dimairo, M., Shephard, N., Hayman, A., Whitehead, A., & Walters, S. J. (2014) · Trials · doi:10.1186/1745-6215-15-264 · Cited by 773 · see citing works

Outcome reporting bias in randomized trials funded by the Canadian Institutes of Health Research

Chan, A.-W. (2004) · Canadian Medical Association Journal · doi:10.1503/cmaj.1041086 · Cited by 444 · see citing works

Effect of Postoperative Analgesia on Major Postoperative Complications: A Systematic Update of the Evidence

Liu, S. S., & Wu, C. L. (2007) · Anesthesia & Analgesia · doi:10.1213/01.ane.0000255040.71600.41 · Cited by 432 · see citing works

Guidance for using pilot studies to inform the design of intervention trials with continuous outcomes

Bell, M. L., Whitehead, A. L., & Julious, S. A. (2018) · Clinical Epidemiology · doi:10.2147/clep.s146397 · Cited by 280 · see citing works

Reporting of sample size calculation in randomised controlled trials: review

Charles, P., Giraudeau, B., Dechartres, A., Baron, G., & Ravaud, P. (2009) · BMJ · doi:10.1136/bmj.b1732 · Cited by 274 · see citing works

Current sample size conventions: Flaws, harms, and alternatives

Bacchetti, P. (2010) · BMC Medicine · doi:10.1186/1741-7015-8-17 · Cited by 233 · see citing works

Evidence at a glance: error matrix approach for overviewing available evidence

Keus, F., Wetterslev, J., Gluud, C. N., & van Laarhoven, C. J. H. M. (2010) · BMC Medical Research Methodology · doi:10.1186/1471-2288-10-90 · Cited by 218 · see citing works

Discrepancies in sample size calculations and data analyses reported in randomised trials: comparison of publications with protocols

Chan, A.-W., Hrobjartsson, A., Jorgensen, K. J., Gotzsche, P. C., & Altman, D. G. (2008) · BMJ · doi:10.1136/bmj.a2299 · Cited by 202 · see citing works

Assessing methods to specify the target difference for a randomised controlled trial: DELTA (Difference ELicitation in TriAls) review

Cook, J., Hislop, J., Adewuyi, T., Harrild, K., Altman, D., Ramsay, C., Fraser, C., Buckley, B., Fayers, P., Harvey, I., et al. (2014) · Health Technology Assessment · doi:10.3310/hta18280 · Cited by 194 · see citing works

SPIRIT 2025 explanation and elaboration: updated guideline for protocols of randomised trials

Hróbjartsson, A., Boutron, I., Hopewell, S., Moher, D., Schulz, K. F., Collins, G. S., Tunn, R., Aggarwal, R., Berkwits, M., Berlin, J. A., et al. (2025) · BMJ · doi:10.1136/bmj-2024-081660 · Cited by 171 · see citing works

Training and fidelity monitoring of behavioral interventions in multi-site addictions research

Baer, J. S., Ball, S. A., Campbell, B. K., Miele, G. M., Schoener, E. P., & Tracy, K. (2007) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2006.08.028 · Cited by 108 · see citing works

Pitfalls in reporting sample size calculation in randomized controlled trials published in leading anaesthesia journals: a systematic review.

Abdulatif, M., Mukhtar, A. M., & Obayah, G. M. (2015) · British Journal of Anaesthesia · doi:10.1093/bja/aev166 · Cited by 78 · see citing works

Outcome Discrepancies and Selective Reporting: Impacting the Leading Journals?

Fleming, P. S., Koletsi, D., Dwan, K., & Pandis, N. (2015) · PLOS ONE · doi:10.1371/journal.pone.0127495 · Cited by 80 · see citing works

Practical Bayesian Design and Analysis for Drug and Device Clinical Trials

Hobbs, B. P., & Carlin, B. P. (2007) · Journal of Biopharmaceutical Statistics · doi:10.1080/10543400701668266 · Cited by 79 · see citing works

High quality of the evidence for medical and other health-related interventions was uncommon in Cochrane systematic reviews

Fleming, P. S., Koletsi, D., Ioannidis, J. P. A., & Pandis, N. (2016) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2016.03.012 · Cited by 73 · see citing works

Proposal of a Clinical Endpoint for Periodontal Trials: The Treat-to-Target Approach.

Feres, M., Retamal‐Valdes, B., Faveri, M., Duarte, P. M., Shibli, J. A., Soares, G. M. S., Miranda, T. S., Teles, F., Goodson, M., Hastürk, H., et al. (2020) · PubMed · Cited by 69 · see citing works

Short term effectiveness of neural sliders and neural tensioners as an adjunct to static stretching of hamstrings on knee extension angle in healthy individuals: A randomized controlled trial

Sharma, S., Balthillaya, G., Rao, R., & Mani, R. (2015) · Physical Therapy in Sport · doi:10.1016/j.ptsp.2015.03.003 · Cited by 64 · see citing works

Sample size calculation in physical medicine and rehabilitation: a systematic review of reporting, characteristics, and results in randomized controlled trials.

Latif, L. A., Amadera, J. E. D., Pimentel, D., Pimentel, T., & Fregni, F. (2011) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2010.10.003 · Cited by 62 · see citing works

The effect of rhythmic-cued motor imagery on walking, fatigue and quality of life in people with multiple sclerosis: A randomised controlled trial

Seebacher, B., Kuisma, R., Glynn, A., & Berger, T. (2016) · Multiple Sclerosis Journal · doi:10.1177/1352458516644058 · Cited by 57 · see citing works

Building an Evidence House: Challenges and Solutions to Research in Complementary and Alternative Medicine

Jonas, W. B. (2005) · Complementary Medicine Research · doi:10.1159/000085412 · Cited by 53 · see citing works

Are Sample Sizes Clear and Justified in RCTs Published in Dental Journals?

Koletsi, D., Fleming, P. S., Seehra, J., Bagos, P. G., & Pandis, N. (2014) · PLoS ONE · doi:10.1371/journal.pone.0085949 · Cited by 53 · see citing works

Outcome reporting discrepancies between trial entries and published final reports of orthodontic randomized controlled trials

Koufatzidou, M., Koletsi, D., Fleming, P. S., Polychronopoulou, A., & Pandis, N. (2019) · European Journal of Orthodontics · doi:10.1093/ejo/cjy046 · Cited by 44 · see citing works

The Association Between Global DNA Methylation and Telomere Length in a Longitudinal Study of Boilermakers

Wong, J. Y. Y., Vivo, I. D., Lin, X., Grashow, R. G., Cavallari, J. M., & Christiani, D. C. (2014) · Genetic Epidemiology · doi:10.1002/gepi.21796 · Cited by 41 · see citing works

The Nonuse, Misuse, and Proper Use of Pilot Studies in Experimental Evaluation Research

Westlund, E., & Stuart, E. A. (2016) · American Journal of Evaluation · doi:10.1177/1098214016651489 · Cited by 39 · see citing works

Heterogeneity in pragmatic randomised trials: sources and management

Giraudeau, B., Caille, A., Eldridge, S. M., Weijer, C., Zwarenstein, M., & Taljaard, M. (2022) · BMC Medicine · doi:10.1186/s12916-022-02569-w · Cited by 38 · see citing works

Reporting of Sample Size Calculations in Analgesic Clinical Trials: ACTTION Systematic Review

McKeown, A., Gewandter, J. S., McDermott, M., Pawlowski, J. R., Poli, J. J., Rothstein, D., Farrar, J. T., Gilron, I., Katz, N. P., Lin, A. H., et al. (2014) · Journal of Pain · doi:10.1016/j.jpain.2014.11.010 · Cited by 35 · see citing works

Sample size for regression analyses of theory of planned behaviour studies: Case of prescribing in general practice

Rashidian, A., Miles, J. N. V., Russell, D., & Russell, I. T. (2006) · British Journal of Health Psychology · doi:10.1348/135910705x66043 · Cited by 36 · see citing works

Acupuncture for persistent allergic rhinitis: a multi-centre, randomised, controlled trial protocol

Kim, J., Lee, M. S., Jung, S., Choi, J., Lee, S., Ko, J.-M., Zhao, H., Zhao, J., Kim, A., Shin, M., et al. (2009) · Trials · doi:10.1186/1745-6215-10-54 · Cited by 35 · see citing works

Standard 4: Determining Adequate Sample Sizes

van der Tweel, I., Askie, L. M., Vandermeer, B., Ellenberg, S. S., Fernandes, R. M., Saloojee, H., Bassler, D., Altman, D. G., Offringa, M., & van der Lee, J. H. (2012) · PEDIATRICS · doi:10.1542/peds.2012-0055g · Cited by 34 · see citing works

Sample size calculations are poorly conducted and reported in many randomized trials of hip and knee osteoarthritis: results of a systematic review

Copsey, B. J., Thompson, J., Vadher, K., Ali, U. M., Dutton, S., Fitzpatrick, R. M., Lamb, S. E., & Cook, J. A. (2018) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2018.08.013 · Cited by 33 · see citing works

The inclusion of real world evidence in clinical development planning

1, O. B. O. G. W., Martina, R., Jenkins, D. A., Bujkiewicz, S., Dequen, P., & Abrams, K. R. (2018) · Trials · doi:10.1186/s13063-018-2769-2 · Cited by 32 · see citing works

Sample size in orthodontic randomized controlled trials: are numbers justified?

Koletsi, D., Pandis, N., & Fleming, P. S. (2013) · European Journal of Orthodontics · doi:10.1093/ejo/cjt005 · Cited by 31 · see citing works

A Pilot Randomized Controlled Trial of an Integrated In-person and Mobile Phone Delivered Counseling and Text Messaging Intervention to Reduce HIV Transmission Risk among Male Sex Workers in Chennai, India

Mimiaga, M. J., Thomas, B. E., Biello, K. B., Johnson, B. E., Swaminathan, S., Navakodi, P., Balaguru, S., Dhanalakshmi, A., Closson, E. F., Menon, S., et al. (2017) · AIDS and Behavior · doi:10.1007/s10461-017-1884-5 · Cited by 29 · see citing works

Corticosteroid injection for shoulder pain: single-blind randomized pilot trial in primary care

Holt, T., Mant, D., Carr, A. J., Gwilym, S., Beard, D. J., Toms, C., Yu, L., & Rees, J. L. (2013) · Trials · doi:10.1186/1745-6215-14-425 · Cited by 29 · see citing works

The power and pitfalls of underpowered studies

Carnahan, R. M., & Brown, G. D. (2024) · Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy · doi:10.1002/phar.4605 · Cited by 27 · see citing works

Rhythmic cued motor imagery and walking in people with multiple sclerosis: a randomised controlled feasibility study

Seebacher, B., Kuisma, R., Glynn, A., & Berger, T. (2015) · Pilot and Feasibility Studies · doi:10.1186/s40814-015-0021-3 · Cited by 26 · see citing works

Sample size calculations for randomized clinical trials published in anesthesiology journals: a comparison of 2010 versus 2016

Chow, J. T. Y., Turkstra, T. P., Yim, E., & Jones, P. M. (2018) · Canadian Journal of Anesthesia/Journal canadien d anesthésie · doi:10.1007/s12630-018-1109-z · Cited by 25 · see citing works

Polyvalent Mechanical Bacterial Lysate Administration Improves the Clinical Course of Grass Pollen–Induced Allergic Rhinitis in Children: A Randomized Controlled Trial

Janeczek, K., Emeryk, A., Rachel, M., Duma, D., Zimmer, Ł., & Poleszak, E. (2020) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2020.08.025 · Cited by 20 · see citing works

Caution regarding the choice of standard deviations to guide sample size calculations in clinical trials

Chen, H.-N., Zhang, N.-H., Lu, X.-S., & Chen, S. (2013) · Clinical Trials · doi:10.1177/1740774513490250 · Cited by 18 · see citing works

Complexities of an Evidence-Based Clinical Practice

Abt, E. (2004) · Journal of Evidence Based Dental Practice · doi:10.1016/j.jebdp.2004.07.023 · Cited by 17 · see citing works

Sample size calculations in pediatric clinical trials conducted in an ICU: a systematic review

Nikolakopoulos, S., Roes, K., van der Lee, J. H., & van der Tweel, I. (2014) · Trials · doi:10.1186/1745-6215-15-274 · Cited by 18 · see citing works

Finding Alternatives to the Dogma of Power Based Sample Size Calculation: Is a Fixed Sample Size Prospective Meta-Experiment a Potential Alternative?

Tavernier, E., Trinquart, L., & Giraudeau, B. (2016) · PLoS ONE · doi:10.1371/journal.pone.0158604 · Cited by 14 · see citing works

Sample Size Calculation: Inaccurate A Priori Assumptions for Nuisance Parameters Can Greatly Affect the Power of a Randomized Controlled Trial

Tavernier, E., & Giraudeau, B. (2015) · PLoS ONE · doi:10.1371/journal.pone.0132578 · Cited by 14 · see citing works

Beyond the P

Wilhelmus, K. R. (2004) · Journal of Cataract & Refractive Surgery · doi:10.1016/j.jcrs.2004.06.083 · Cited by 13 · see citing works

Methods of Determining Sample Sizes

Ryan, T. P. (2013) · Wiley series in probability and statistics · doi:10.1002/9781118439241.ch2 · Cited by 13 · see citing works

Does the presence of a pharmacological substance alter the placebo effect?—results of two experimental studies using the placebo‐caffeine paradigm

Walach, H., & Schneider, R. (2009) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.1054 · Cited by 12 · see citing works

Assessing “Spin” in Urology Randomized Controlled Trials With Statistically Nonsignificant Primary Outcomes

Wu, J., Ho, W., Klotz, L. H., Yuan, M., Lee, J. Y., & Krakowsky, Y. (2022) · The Journal of Urology · doi:10.1097/ju.0000000000003105 · Cited by 11 · see citing works

Sensory Stimulation of the Foot and Ankle Early Post-stroke: A Pilot and Feasibility Study

Aries, A., Pomeroy, V. M., Sim, J., Read, S. M., & Hunter, S. M. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.675106 · Cited by 11 · see citing works

Beyond the P

Wilhelmus, K. R. (2004) · Journal of Cataract & Refractive Surgery · doi:10.1016/j.jcrs.2004.06.052 · Cited by 11 · see citing works

Effect on Hospital Length of Stay of Tourniquet Use During Internal Fixation of Ankle Fractures: Randomized Controlled Trial

Sim, J., Grocott, N., Majeed, H., & McClelland, D. (2018) · The Journal of Foot & Ankle Surgery · doi:10.1053/j.jfas.2018.08.023 · Cited by 10 · see citing works

The Effects of Randomized Controlled Trials on Vertebroplasty and Kyphoplasty: A Square Peg in a Round Hole

Albers, S. L. (2013) · Pain Physician · doi:10.36076/ppj.2013/16/e331 · Cited by 9 · see citing works

Explicación del tamaño muestral empleado: una exigencia irracional de las revistas biomédicas

Ayçaguer, L. C. S., & Galbán, P. A. (2012) · Gaceta Sanitaria · doi:10.1016/j.gaceta.2012.01.017 · Cited by 9 · see citing works

Pitfalls in the design and analysis of paediatric clinical trials: a case of a ‘failed’ multi‐centre study, and potential solutions

van der Lee, J. H., Tanck, M. W. T., Wesseling, J., & Offringa, M. (2008) · Acta Paediatrica · doi:10.1111/j.1651-2227.2008.01048.x · Cited by 9 · see citing works

Conservative Sample Size Estimation in Nonparametrics

Martini, D. D. (2010) · Journal of Biopharmaceutical Statistics · doi:10.1080/10543400903453343 · Cited by 9 · see citing works

A generalized concept of power helped to choose optimal endpoints in clinical trials

Borm, G. F., van der Wilt, G. J., Kremer, J. A. M., & Zielhuis, G. A. (2006) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2006.06.015 · Cited by 9 · see citing works

Adding nails to the coffin of underpowered trials.

Halpern, S. D. (2005) · PubMed · Cited by 8 · see citing works

Estudios “pequeños”: ¿cuál es la importancia del tamaño en los estudios clínicos?

Araujo, M. (2011) · Medwave · doi:10.5867/medwave.2011.06.5060 · Cited by 7 · see citing works

Small Sample Approach, and Statistical and Epidemiological Aspects

Offringa, M., & van der Lee, H. (2011) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-20195-0_9 · Cited by 6 · see citing works

Current practice in methodology and reporting of the sample size calculation in randomised trials of hip and knee osteoarthritis: a protocol for a systematic review

Copsey, B. J., Dutton, S., Fitzpatrick, R. M., Lamb, S. E., & Cook, J. A. (2017) · Trials · doi:10.1186/s13063-017-2209-8 · Cited by 5 · see citing works

Feasibility of a specific task-oriented training versus its combination with manual therapy on balance and mobility in people post stroke at the chronic stage: study protocol for a pilot randomised controlled trial

Traxler, K., Schinabeck, F., Baum, E., Klotz, E., & Seebacher, B. (2021) · Pilot and Feasibility Studies · doi:10.1186/s40814-021-00886-0 · Cited by 5 · see citing works

Assessing variability and uncertainty in orthopedic randomized controlled trials

Raittio, L., & Reito, A. R. (2020) · Acta Orthopaedica · doi:10.1080/17453674.2020.1755932 · Cited by 5 · see citing works

Recovery of balance and walking in people with ataxia after acute cerebral stroke: study protocol for a prospective, monocentric, single-blinded, randomized controlled trial

Meier, P., Mayer‐Suess, L., Kiechl, S., Pachmann, U., Greimann, R., Köfler, M., Brenneis, C., Grams, A. E., Steiger, R., & Seebacher, B. (2024) · Frontiers in Stroke · doi:10.3389/fstro.2024.1388891 · Cited by 4 · see citing works

Investigating started sample size, completed sample size and drop‐out rate in 10 252 phase III clinical trials: Insights from ClinicalTrials.gov

Chen, H.-N., Pang, J., Zhao, Y., Cao, B.-W., Valente, M., Cen, W.-L., & Valkanova, E. (2025) · British Journal of Clinical Pharmacology · doi:10.1002/bcp.70023 · Cited by 4 · see citing works

Urological trials without significant results. Can we extract meaning from disappointment?

Noll, D., Stapleton, P., & O’Callaghan, M. (2026) · British Journal of Urology · doi:10.1111/bju.70140 · Cited by 3 · see citing works

Digital Alcohol Interventions Could Be Part of the Societal Response to Harmful Consumption, but We Know Little About Their Long-Term Costs and Health Outcomes

Gunnarsson, K. U., Henriksson, M., & Bendtsen, M. (2024) · Journal of Medical Internet Research · doi:10.2196/44574 · Cited by 3 · see citing works

The Power of Prehabilitation, the Reporting of Power Calculations in Randomized Clinical Trials Evaluating Prehabilitation in Cancer Surgery: A Systematic Review and Meta-research Study

Venter, S., Liu, X., Koh, C., Solomon, M. J., Cole, R., Hirst, N. G., & Steffens, D. (2025) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2025.01.465 · Cited by 3 · see citing works

The equivalence of two approaches to incorporating variance uncertainty in sample size calculations for linear statistical models

Shieh, G. (2016) · Journal of Applied Statistics · doi:10.1080/02664763.2016.1158797 · Cited by 3 · see citing works

Bayesian Sample Size Calculations for Comparing Two Strategies in SMART Studies

Turchetta, A., Moodie, E. E. M., Stephens, D. A., & Lambert, S. (2022) · Biometrics · doi:10.1111/biom.13813 · Cited by 3 · see citing works

Fallzahlberechnung in forensisch-anthropologischen Studien

Ramsthaler, F., Burkholder, I., Kettner, M., & Verhoff, M. A. (2013) · Rechtsmedizin · doi:10.1007/s00194-013-0876-7 · Cited by 3 · see citing works

Probability of success: estimation framework, properties and applications

Hu, P. H. (2014) · Stat · doi:10.1002/sta4.52 · Cited by 3 · see citing works

Heart Rate Variability and Chagas Heart Disease

Almeida-Santos, M. A., & Sousa, A. C. S. (2015) · Arquivos Brasileiros de Cardiologia · doi:10.5935/abc.20150003 · Cited by 3 · see citing works

Core concepts in statistics and research methods. Part 6: Sample size calculations

Bould, M. D., & McIsaac, D. (2026) · BJA Education · doi:10.1016/j.bjae.2026.02.002 · Cited by 2 · see citing works

El Cálculo del Tamaño Muestral en Ciencias de la Salud: Recomendaciones y Guía Práctica

Fernández-Matías, R. (2023) · Journal of MOVE and Therapeutic Science · doi:10.37382/jomts.v5i1.915 · Cited by 4 · see citing works

Optimizing clinical scientific research: the cohort intervention random sampling study with historical controls

de Klerk, N. D., Berben, P. B. Q., van der Ven, M., Fransen, A. F., der Jagt, M. B. V. D. H., Oei, S. G., van Laar, J. O. E. H., & van den Heuvel, E. R. (2025) · Journal of Comparative Effectiveness Research · doi:10.57264/cer-2024-0168 · Cited by 2 · see citing works

Failure of Cardiovascular Phase 3 Randomized Clinical Trials to Report Pre-trial and Post-trial Parameters: a Cross-sectional Analysis of ClinicalTrials.gov

Zheutlin, A. R., Niforatos, J. D., Stulberg, E. L., & Sussman, J. B. (2020) · Journal of General Internal Medicine · doi:10.1007/s11606-020-05995-9 · Cited by 2 · see citing works

Examining the Advantages and Disadvantages of Pilot Studies: Monte-Carlo Simulations

Nakazawa, M. (2012) · UNM’s Digital Repository (University of New Mexico) · Cited by 2 · see citing works

On Using a Pilot Sample Variance for Sample Size Determination in the Detection of Differences between Two Means: Power Consideration.

Shieh, G. (2013) · Redalyc (Universidad Autónoma del Estado de México) · Cited by 2 · see citing works

Dietary Amelioration of Helicobacter pylori Infection: Design Criteria for a Clinical Trial

Fahey, J. W., Muñoz, Á., Matsuzaki, Y., Suzuki, H., Talalay, P., Tauchi, M., Zhang, S., Hurt, C. N., & Yanaka, A. (2004) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.1610.13.10 · Cited by 2 · see citing works

Are treatment effect assumptions in orthodontic studies overoptimistic?

Seehra, J., Stonehouse‐Smith, D., Cobourne, M. T., Tsagris, M., & Pandis, N. (2021) · European Journal of Orthodontics · doi:10.1093/ejo/cjab018 · Cited by 2 · see citing works

Una pincelada estadística con repercusiones extrametodológicas

Ayçaguer, L. C. S. (2011) · Salud Colectiva · doi:10.18294/sc.2011.274 · Cited by 2 · see citing works

Methods of sample size calculation for clinical trials

Tracy, M. (2009) · Enlighten: Theses (The University of Glasgow) · Cited by 2 · see citing works

Successful completion of large, low-cost randomized cancer trials at an academic cancer center

Vickers, A. J., Ehdaie, B., Tokita, H. K., Nelson, J. A., Matros, E., Pusic, A. L., & D'Angelica, M. I. (2024) · Clinical Trials · doi:10.1177/17407745241284044 · Cited by 1 · see citing works

Cerclaje para la prevención de embarazo de pretérmino en mujeres con cervix corto encontrado en ecografía transvaginal: un estudio randomizado

Paula Vargas, I., P-G, C. V., & Jorge Carvajal, C. (2004) · Revista chilena de obstetricia y ginecología · doi:10.4067/s0717-75262004000600014 · Cited by 1 · see citing works

Assessment of enterprise risk management maturity levels of the insurance industry in Botswana

Ngwenya, M. (2017) · Unisa Institutional Repository (University of South Africa) · Cited by 1 · see citing works

Clinical Trials

Ryan, T. P. (2013) · Wiley series in probability and statistics · doi:10.1002/9781118439241.ch7 · Cited by 1 · see citing works

Dosis única adicional como tratamiento en el posparto para mujeres con corioamnionitis

Ivonne Escobar, G., P-G, C. V., & Jorge Carvajal, C. (2005) · Revista chilena de obstetricia y ginecología · doi:10.4067/s0717-75262005000100012

Cerclaje para la prevención de embarazo de pretérmino en mujeres con cervix corto encontrado en ecografía transvaginal: un estudio

Materno-Fetal, U. D. M. (2004)

Prevention of type 2 diabetes in people living with HIV : understanding risk factors, and investigating the effectiveness and acceptability of a lifestyle intervention

Duncan, A. (2016) · Research Portal (King's College London)

Author's Response

Mulhall, J. P. (2005) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2005.00081_4.x

Phase III Sample Size Based on the 'Power to Detect' Is Logically Wrong and Usually UnethicalPreprint

Martini, D. D. (2019) · SSRN Electronic Journal · doi:10.2139/ssrn.3328810

Bayesian Sample Size Calculations for SMART StudiesPreprint

Turchetta, A., Moodie, E. E. M., Stephens, D. A., & Lambert, S. (2021) · arXiv (Cornell University) · doi:10.48550/arxiv.2108.01041

Research Reviews: Acupuncture for Chronic Low Back Pain (N=60)

(2004) · Acupuncture in Medicine · doi:10.1136/aim.22.1.53

Quality and quantity of clinical trials on low back pain published by Indian physiotherapists

Suhail, A., & Quais, S. (2024) · Bulletin of Faculty of Physical Therapy · doi:10.1186/s43161-024-00185-8

Delta Inflation, Optimism Bias, and Uncertainty in Clinical Trials

Liu, C. C., Wu, P., & Yu, R. (2024) · Therapeutic Innovation & Regulatory Science · doi:10.1007/s43441-024-00697-4

Exploratory research on the reform of diversified teaching methods in residency training education: a case study of orthopedics

Fang, D., An, S., Zou, Q., Liu, H.-Y., Jin, H., & Cheng, Q. (2025) · Global Medical Education · doi:10.1515/gme-2024-0030

The rational use of available evidence before extrapolating the benefit risk ratio from adults to children

Janiaud, P. (2017) · doi:10.70675/6d5fe65ezec32z4cfczb386z141920af6de0

Intérêt d'une approche de type "méta-analyse prospective d'essais de taille fixe" dans l'évaluation thérapeutique

Tavernier, E. (2016) · doi:10.70675/dc94d400ze0b4z4d1fzbb24z29bfd936144b

Caution regarding the choice of standard deviations to guide sample size calculations in clinical trials

Chen, H.-N., Zhang, N.-H., Lu, X.-S., & Chen, S. (2013) · Clinical Trials · doi:10.1177/1740774513490250 · Cited by 18 · see citing works

Reporting of sample size calculation in randomised controlled trials: review

Charles, P., Giraudeau, B., Dechartres, A., Baron, G., & Ravaud, P. (2009) · BMJ · doi:10.1136/bmj.b1732 · Cited by 274 · see citing works

Sample size calculations in surgery: Are they done correctly?

Maggard, M. A., O’Connell, J. B., Liu, J. H., Etzioni, D. A., & Ko, C. Y. (2003) · Surgery · doi:10.1067/msy.2003.235 · Cited by 61 · see citing works

Sample size calculations in randomised trials: mandatory and mystical

Schulz, K. F., & Grimes, D. A. (2005) · The Lancet · doi:10.1016/s0140-6736(05)61034-3 · Cited by 549 · see citing works

Understanding the relevance of sample size calculation

Nayak, B. (2010) · Indian Journal of Ophthalmology · doi:10.4103/0301-4738.71673 · Cited by 237 · see citing works