Cited by 122Health Promotion and Cardiovascular PreventionCardiovascular Health and Risk FactorsHealthcare Systems and Public Health

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Joint analysis of three U.S. community intervention trials for reduction of cardiovascular disease risk

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Winkleby, Marilyn A., Feldman, Henry A., Murray, David M.·1997·Journal of Clinical Epidemiology

DOI 10.1016/s0895-4356(97)00020-6

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Abstract

During the 1980s three comprehensive community-based heart disease prevention trials were conducted in the United States. The Stanford Five-City Project, Minnesota Heart Health Program, and Pawtucket Heart Health Program involved 12 cities; six received a 5-8 year multifactorial risk reduction program. This analysis pools data from the three studies to delineate the common intervention effects with greater sample size and power than could be attained by the single studies. Time trends were estimated for cigarette smoking, blood pressure, total cholesterol, body mass index, and coronary heart disease mortality risk in women and men aged 25-64 years. The joint estimates of intervention effect were in the expected direction in nine of 12 gender-specific comparisons; however, these were not statistically significant. The results illustrate the analytic challenges of evaluating community-based prevention trials and point to the smaller than expected net differences, rather than small sample size, as the reason for few statistically significant effects in the three U.S. prevention trials.

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Authors: Winkleby, M. A., Feldman, H. A., & Murray, D. M.
Affiliations: Stanford University (US)
Memorial Hospital of Rhode Island (US)
University of Minnesota (US)
Corresponding author: Winkleby, Marilyn A.
ORCID: Feldman, Henry A.
Murray, David M.
Venue: Journal of Clinical Epidemiology
Publisher: Elsevier BV
Published: 1997-06
Volume: 50
Issue: 6
Pages: 645-658
ISSN: 0895-4356 (ISSN-L)
DOI: 10.1016/s0895-4356(97)00020-6
OpenAlex: W2099139180
Cited by: 122
References: 69
Citations by year: 2026: 1 · 2024: 1 · 2023: 1 · 2021: 1 · 2020: 4 · 2018: 3 · 2017: 1 · 2016: 3 · 2015: 3 · 2014: 3 · 2012: 3
FWCI: 9.62
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by-nc-nd/4.0/ (vor, 583 d)
Locations: Journal of Clinical Epidemiology (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01hl023629-15, 5r01hl025523-13, 5r01hl021906-19)
National Heart, Lung, and Blood Institute (HL-23629, HL21906, HL 25523)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Health Promotion and Cardiovascular Prevention
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
Health Sciences › Medicine › Epidemiology › Healthcare Systems and Public Health
Keywords: cardiovascular disease prevention, community-based intervention, pooled analysis, smoking, blood pressure, total cholesterol, body mass index, coronary heart disease mortality, middle-aged adults, intervention effect estimation, temporal trends
MeSH terms: Blood Pressure, Cardiovascular Diseases, Cholesterol, Cross-Sectional Studies, Female, Health Education, Humans, Male, Risk, Risk Factors, Smoking, Socioeconomic Factors, Time Factors, United States, Confounding Factors, Epidemiologic, Body Mass Index, Treatment Outcome

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Joint analysis of three U.S. community intervention trials for reduction of cardiovascular disease risk

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