The DOI matches its Crossref record; 128 of the 128 references it cites were found in a registry or an index.
Nicotinic Receptors in the Development and Modulation of CNS Synapses
Open accessAbstract
The molecular dissection of muscle-type nicotinic acetylcholine receptors (nAChRs) with gene cloning techniques set the stage for similar analyses of ligand-gated ion channels in brain (Numa et al. 1983). The first neuronal representative of this gene family was described in 1986 by Heinemann, Patrick, and their colleagues with the cloning of an α-type nAChR subunit gene expressed in the vertebrate nervous system (Boulter et al. 1986). In contrast with muscle nAChRs, where the primary sequences of the α and β subunits are highly conserved, the primary structures of the neuronal nAChR α and β subunits are diverse (seeLe Novere and Changeux 1995; Ortells and Lunt 1995). The functional profiles of the resultant receptor complexes are comparably varied: neurons in both the CNS and PNS express a variety of ACh-gated channels that differ from muscle nAChRs and from one another in conductance, kinetics, ion permeability, pharmacological profile, and subcellular localization (for reviews seeSargent 1993; Patrick et al. 1993; McGehee and Role 1995).
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“ACh signaling is essential for neuronal development, where it plays a trophic role in establishing and maintaining neuronal connectivity [111, 112].”
From Adolescent nicotine exposure and persistent neurocircuitry changes: unveiling lifelong psychiatric risks (2025) · cites this paper as [112]
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Metadata
- Authors
- Role, L. W., & Berg, D. K.
- Affiliations
- Columbia University (US)
- University of California San Diego (US)
- Corresponding author
- Role, Lorna W
- ORCID
- Role, Lorna W
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 1996-06
- Volume
- 16
- Issue
- 6
- Pages
- 1077-1085
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2051606745
- Cited by
- 762
- References
- 128
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 8 · 2023: 6 · 2022: 4 · 2021: 9 · 2020: 19 · 2019: 7 · 2018: 10 · 2017: 3 · 2016: 11 · 2015: 17 · 2014: 19 · 2013: 18 · 2012: 20
- FWCI
- 5.14
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Neuron (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Keywords
- nicotinic acetylcholine receptors, neuronal nicotinic receptors, ligand-gated ion channels, synaptic development, synaptic modulation, ion permeability
- MeSH terms
- Animals, Central Nervous System, Receptors, Nicotinic, Synapses
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