The DOI matches its Crossref record; 128 of the 128 references it cites were found in a registry or an index.
Nicotinic Receptors in the Development and Modulation of CNS Synapses
Open accessAbstract
The molecular dissection of muscle-type nicotinic acetylcholine receptors (nAChRs) with gene cloning techniques set the stage for similar analyses of ligand-gated ion channels in brain (Numa et al. 1983). The first neuronal representative of this gene family was described in 1986 by Heinemann, Patrick, and their colleagues with the cloning of an α-type nAChR subunit gene expressed in the vertebrate nervous system (Boulter et al. 1986). In contrast with muscle nAChRs, where the primary sequences of the α and β subunits are highly conserved, the primary structures of the neuronal nAChR α and β subunits are diverse (seeLe Novere and Changeux 1995; Ortells and Lunt 1995). The functional profiles of the resultant receptor complexes are comparably varied: neurons in both the CNS and PNS express a variety of ACh-gated channels that differ from muscle nAChRs and from one another in conductance, kinetics, ion permeability, pharmacological profile, and subcellular localization (for reviews seeSargent 1993; Patrick et al. 1993; McGehee and Role 1995).
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“ACh signaling is essential for neuronal development, where it plays a trophic role in establishing and maintaining neuronal connectivity [111, 112].”
From Adolescent nicotine exposure and persistent neurocircuitry changes: unveiling lifelong psychiatric risks (2025) · cites this paper as [112]
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Cites
Séguéla, P., Wadiche, J. I., Dineley‐Miller, K., Dani, J., & Jw, P. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-02-00596.1993 · Cited by 1,471
Nicotine enhancement of fast excitatory synaptic transmission in CNS by presynaptic receptors
McGehee, D. S., Heath, M. J. S., Gelber, S., Devay, P., & Role, L. W. (1995) · Science · doi:10.1126/science.7569895 · Cited by 1,070
Self-citationThe Diversity of Neuronal Nicotinic Acetylcholine Receptors
Sargent, P. B. (1993) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.16.030193.002155 · Cited by 1,052
Physiological Diversity of Nicotinic Acetylcholine Receptors Expressed by Vertebrate Neurons
McGehee, D. S., & Role, L. W. (1995) · Annual Review of Physiology · doi:10.1146/annurev.ph.57.030195.002513 · Cited by 1,022
Self-citationCholinergic systems in mammalian brain and spinal cord
WOOLF, N. (1991) · Progress in Neurobiology · doi:10.1016/0301-0082(91)90006-m · Cited by 948
Couturier, S., Bertrand, D., Matter, J., Hernandez, M., Bertrand, S., Millar, N. S., Valera, S., BARKAS, T., & Ballivet, M. (1990) · Neuron · doi:10.1016/0896-6273(90)90344-f · Cited by 941
Elgoyhen, A. B., Johnson, D. S., Boulter, J., Vetter, D. E., & Heinemann, S. (1994) · Cell · doi:10.1016/0092-8674(94)90555-x · Cited by 899
ATP receptor-mediated synaptic currents in the central nervous system
Edwards, F. A., Gibb, A. J., & Colquhoun, D. M. (1992) · Nature · doi:10.1038/359144a0 · Cited by 815
Stimulation of Neuronal Acetylcholine Receptors Induces Rapid Gene Transcription
Greenberg, M. E., Ziff, E. B., & Greene, L. A. (1986) · Science · doi:10.1126/science.3749894 · Cited by 761
Abnormal avoidance learning in mice lacking functional high-affinity nicotine receptor in the brain
Picciotto, M. R., Zoli, M., Léna, C., Bessis, A., Lallemand, Y., LeNovère, N., Vincent, P., Pich, E. M., Brûlet, P., & Changeux, J.-P. (1995) · Nature · doi:10.1038/374065a0 · Cited by 668
Research works printed but not linked: 1
- Chiappinelli, V.A. (1991). κ-Neurotoxins and α-neurotoxins: effects on neuronal nicotinic acetylcholine receptors. In Snake Toxins, A.L. Harvey, ed. (New York: Permagon Press), pp. 223–258.
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Alzheimer's disease: Targeting the Cholinergic System
H. Ferreira-Vieira, T., M. Guimaraes, I., R. Silva, F., & M. Ribeiro, F. (2016) · Current Neuropharmacology · doi:10.2174/1570159x13666150716165726 · Cited by 1,551
International Union of Pharmacology. XVII. Classification of Muscarinic Acetylcholine Receptors
Caulfield, M. P., & Birdsall, N. J. M. (1998) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01362-0 · Cited by 1,474
Acetylcholine as a Neuromodulator: Cholinergic Signaling Shapes Nervous System Function and Behavior
Picciotto, M. R., Higley, M. J., & Mineur, Y. S. (2012) · Neuron · doi:10.1016/j.neuron.2012.08.036 · Cited by 1,404
Picciotto, M. R., Zoli, M., Rimondini, R., Léna, C., Marubio, L. M., Pich, E. M., Fuxe, K., & Changeux, J.-P. (1998) · Nature · doi:10.1038/34413 · Cited by 1,320
Presynaptic nicotinic ACh receptors
Wonnacott, S. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)10073-4 · Cited by 1,308
Metadata
- Authors
- Role, L. W., & Berg, D. K.
- Affiliations
- Columbia University (US)
- University of California San Diego (US)
- Corresponding author
- Role, Lorna W
- ORCID
- Role, Lorna W
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 1996-06
- Volume
- 16
- Issue
- 6
- Pages
- 1077-1085
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2051606745
- Cited by
- 762
- References
- 128
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 8 · 2023: 6 · 2022: 4 · 2021: 9 · 2020: 19 · 2019: 7 · 2018: 10 · 2017: 3 · 2016: 11 · 2015: 17 · 2014: 19 · 2013: 18 · 2012: 20
- FWCI
- 5.14
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Neuron (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Keywords
- nicotinic acetylcholine receptors, neuronal nicotinic receptors, ligand-gated ion channels, synaptic development, synaptic modulation, ion permeability
- MeSH terms
- Animals, Central Nervous System, Receptors, Nicotinic, Synapses
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