Cited by 762Nicotinic Acetylcholine Receptors StudyNeuroscience and Neuropharmacology ResearchIon channel regulation and function

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Nicotinic Receptors in the Development and Modulation of CNS Synapses

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Role, Lorna W, Berg, Darwin K·1996·Neuron

DOI 10.1016/s0896-6273(00)80134-8

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Abstract

The molecular dissection of muscle-type nicotinic acetylcholine receptors (nAChRs) with gene cloning techniques set the stage for similar analyses of ligand-gated ion channels in brain (Numa et al. 1983). The first neuronal representative of this gene family was described in 1986 by Heinemann, Patrick, and their colleagues with the cloning of an α-type nAChR subunit gene expressed in the vertebrate nervous system (Boulter et al. 1986). In contrast with muscle nAChRs, where the primary sequences of the α and β subunits are highly conserved, the primary structures of the neuronal nAChR α and β subunits are diverse (seeLe Novere and Changeux 1995; Ortells and Lunt 1995). The functional profiles of the resultant receptor complexes are comparably varied: neurons in both the CNS and PNS express a variety of ACh-gated channels that differ from muscle nAChRs and from one another in conductance, kinetics, ion permeability, pharmacological profile, and subcellular localization (for reviews seeSargent 1993; Patrick et al. 1993; McGehee and Role 1995).

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Authors: Role, L. W., & Berg, D. K.
Affiliations: Columbia University (US)
University of California San Diego (US)
Corresponding author: Role, Lorna W
ORCID: Role, Lorna W
Venue: Neuron
Publisher: Elsevier BV
Published: 1996-06
Volume: 16
Issue: 6
Pages: 1077-1085
ISSN: 0896-6273 (ISSN-L)
DOI: 10.1016/s0896-6273(00)80134-8
OpenAlex: W2051606745
Cited by: 762
References: 128
Citations by year: 2026: 1 · 2025: 5 · 2024: 8 · 2023: 6 · 2022: 4 · 2021: 9 · 2020: 19 · 2019: 7 · 2018: 10 · 2017: 3 · 2016: 11 · 2015: 17 · 2014: 19 · 2013: 18 · 2012: 20
FWCI: 5.14
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by-nc-nd/4.0/ (vor, 1775 d)
Locations: Neuron (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
Keywords: nicotinic acetylcholine receptors, neuronal nicotinic receptors, ligand-gated ion channels, synaptic development, synaptic modulation, ion permeability
MeSH terms: Animals, Central Nervous System, Receptors, Nicotinic, Synapses

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Nicotinic Receptors in the Development and Modulation of CNS Synapses

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