Abnormal avoidance learning in mice lacking functional high-affinity nicotine receptor in the brain
Abstract
Nicotine affects many aspects of behaviour including learning and memory through its interaction with neuronal nicotinic acetylcholine receptors (nAChR). Functional nAChRs are pentameric proteins containing at least one type of alpha-subunit and one type of beta-subunit. The involvement of a particular neuronal nicotinic subunit in pharmacology and behaviour was examined using gene targeting to mutate beta 2, the most widely expressed nAChR subunit in the central nervous system. We report here that high-affinity binding sites for nicotine are absent from the brains of mice homozygous for the beta 2-subunit mutation. Further, electrophysiological recording from brain slices reveals that thalamic neurons from these mice do not respond to nicotine application. Finally, behavioural tests demonstrate that nicotine no longer augments the performance of beta 2-1- mice on passive avoidance, a test of associative memory. Paradoxically, mutant mice are able to perform better than their non-mutant siblings on this task.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
β2* nAChRs have the highest affinity for nicotine and other agonists, while α7* nAChRs have a lower affinity for nicotine in vitro.
“The β2* nAChRs are thought to have the highest affinity for nicotine and other agonists (Lippiello et al., 1987; McGehee and Role, 1995; Picciotto et al., 1995) while α7* nAChRs are thought to have a lower affinity for nicotine in vitro (Papke and Thinschmidt, 1998; Wonnacott, 1986).”
From It is not “either/or”: Activation and desensitization of nicotinic acetylcholine receptors both contribute to behaviors related to nicotine addiction and mood (2008) · cites this paper as Picciotto et al., 1995
Cytisine blocks α4/β2* nAChRs but activates α3/β4* and α7* nAChRs.
“cytisine, a nicotinic partial agonist that blocks α4/β2* nAChRs but activates α3/β4* and α7* nAChRs (Papke and Porter Papke, 2002; Picciotto et al., 1995)”
From It is not “either/or”: Activation and desensitization of nicotinic acetylcholine receptors both contribute to behaviors related to nicotine addiction and mood (2008) · cites this paper as Picciotto et al., 1995
The hypersensitive passive avoidance performance behavior exhibited by β2 knockout mice can be normalized by transgenic expression of this subunit exclusively in corticothalamic neurons during development.
“the hypersensitive passive avoidance performance behavior exhibited by β2 knockout mice [33] can be normalized by transgenic expression of this subunit exclusively in corticothalamic neurons during development [27, 28].”
From Impaired auditory discrimination learning following perinatal nicotine exposure or β2 nicotinic acetylcholine receptor subunit deletion (2012) · cites this paper as [33]
Cites
Molecular Cloning: A Laboratory Manual
Sambrook, J., Fritsch, E., & Maniatis, T. (1989) · UCLA - Biblioteca de Ciencias de la Salud · Cited by 133,589 · see citing works
Molecular cloning: A laboratory manual
Deininger, P. L. (1990) · Analytical Biochemistry · doi:10.1016/0003-2697(90)90595-z · Cited by 84,684 · see citing works
Impaired Spatial Learning in α-Calcium-Calmodulin Kinase II Mutant Mice
Silva, A. J., Paylor, R. E., Wehner, J. M., & Tonegawa, S. (1992) · Science · doi:10.1126/science.1321493 · Cited by 1,351 · see citing works
The Diversity of Neuronal Nicotinic Acetylcholine Receptors
Sargent, P. B. (1993) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.16.030193.002155 · Cited by 1,052 · see citing works
Wada, E., Wada, K., Boulter, J., Deneris, E. S., Heinemann, S., Patrick, J., & Swanson, L. W. (1989) · The Journal of Comparative Neurology · doi:10.1002/cne.902840212 · Cited by 1,044 · see citing works
Clarke, P. B. S., Schwartz, R., Paul, S. M., Cb, P., & Pert, A. (1985) · Journal of Neuroscience · doi:10.1523/jneurosci.05-05-01307.1985 · Cited by 1,037 · see citing works
Morris, R. (1989) · Journal of Neuroscience · doi:10.1523/jneurosci.09-09-03040.1989 · Cited by 765 · see citing works
Exploratory behavior models of anxiety in mice
Crawley, J. N. (1985) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(85)90030-2 · Cited by 756 · see citing works
Luetje, C., & Patrick, J. (1991) · The Journal of Neuroscience · doi:10.1523/jneurosci.11-03-00837.1991 · Cited by 558 · see citing works
Nicotine binding and nicotinic receptor subunit RNA after chronic nicotine treatment
Marks, M., Pauly, Jr., Gross, S., Deneris, E., Hermans-Borgmeyer, I., Heinemann, S., & Collins, A. (1992) · The Journal of Neuroscience · doi:10.1523/jneurosci.12-07-02765.1992 · Cited by 551 · see citing works
Nicotinic systems and cognitive function
Levin, E. D. (1992) · Psychopharmacology · doi:10.1007/bf02247415 · Cited by 511 · see citing works
Flicker, C., DEAN, R., Watkins, D. L., FISHER, S., & Bartus, R. T. (1983) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(83)80023-9 · Cited by 370 · see citing works
Homeosis in the mouse induced by a null mutation in the Hox-3.1 gene
Mouellic, H. L., Lallemand, Y., & Brûlet, P. (1992) · Cell · doi:10.1016/0092-8674(92)90406-3 · Cited by 356 · see citing works
Self-citationFunctional Architecture Of The Nicotinic Acetylcholine Receptor: From Electric Organ To Brain
Galzi, J., Revah, F., Bessis, A., & Changeux, J. (1991) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.31.040191.000345 · Cited by 332 · see citing works
Self-citationStereospecific Nicotine Receptors on Rat Brain Membranes
Romano, C., & D, A. G. M. (1980) · Science · doi:10.1126/science.7433991 · Cited by 318 · see citing works
Anand, R., Conroy, W. G., Schoepfer, R., Whiting, P. J., & Lindstrom, J. M. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)99147-7 · Cited by 315 · see citing works
A new mouse embryonic stem cell line with good germ line contribution and gene targeting frequency
Magin, T. M., McWhir, J., & Melton, D. W. (1992) · Nucleic Acids Research · doi:10.1093/nar/20.14.3795 · Cited by 251 · see citing works
Yagi, T., Ikawa, Y., Yoshida, K., Shigetani, Y., Takeda, N., Mabuchi, I., Yamamoto, T., & Aizawa, S. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.24.9918 · Cited by 238 · see citing works
Immunocytochemical localization of a neuronal nicotinic receptor: the beta 2-subunit
Hill, J., Zoli, M., Bourgeois, J., & Changeux, J. (1993) · The Journal of Neuroscience · doi:10.1523/jneurosci.13-04-01551.1993 · Cited by 220 · see citing works
Self-citationDecker, M. W., Brioni, J. D., Sullivan, J. P., Buckley, M. J., Radek, R. J., Raszkiewicz, J. L., Kang, C. H., Kim, D. J., Giardina, W. J., & Wasicak, J. T. (1994) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)22339-4 · Cited by 180 · see citing works
Selfridge, J., Pow, A. M., McWhir, J., Magin, T. M., & Melton, D. W. (1992) · Somatic Cell and Molecular Genetics · doi:10.1007/bf01235756 · Cited by 110 · see citing works
Swanson, L. W., Lindstrom, J. M., Tzartos, S. J., Schmued, L. C., O'Leary, D. D. M., & Cowan, W. M. (1983) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.80.14.4532 · Cited by 105 · see citing works
(S)‐3‐メチル‐5‐(1‐メチル‐2‐ピロリジニル)イソキサゾール(ART418) 認知促進および抗不安活性を持つ新しいコリン作動性リガンド II in vivoの性質
Decker, M. W., Brioni, J. D., Sullivan, J. P., et al. (1994) · Journal of Pharmacology and Experimental Therapeutics · Cited by 92 · see citing works
EFFECTS OF MECAMYLAMINE ON AVOIDANCE CONDITIONING AND MAZE LEARNING OF MICE
Oliverio, A. (1966) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)27477-8 · Cited by 61 · see citing works
A two-compartment exploratory model to study anxiolytic/anxiogenic effects of drugs in the rat
Pich, E. M., & SAMANIN, R. (1989) · Pharmacological Research · doi:10.1016/1043-6618(89)90201-6 · Cited by 52 · see citing works
Self-citationEffect of Nicotine on Passive Avoidance Behaviour and Motoric Activity in Mice
Nordberg, A. K., & Bergh, C. (1985) · Acta Pharmacologica et Toxicologica · doi:10.1111/j.1600-0773.1985.tb01300.x · Cited by 45 · see citing works
Faiman, C. P., de Erausquin, G. A., & Baratti, C. M. (1991) · Behavioral and Neural Biology · doi:10.1016/0163-1047(91)90592-e · Cited by 28 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Acetylcholine as a Neuromodulator: Cholinergic Signaling Shapes Nervous System Function and Behavior
Picciotto, M. R., Higley, M. J., & Mineur, Y. S. (2012) · Neuron · doi:10.1016/j.neuron.2012.08.036 · Cited by 1,404 · see citing works
Self-citationPicciotto, M. R., Zoli, M., Rimondini, R., Léna, C., Marubio, L. M., Pich, E. M., Fuxe, K., & Changeux, J.-P. (1998) · Nature · doi:10.1038/34413 · Cited by 1,320 · see citing works
Self-citationNicotinic Acetylcholine Receptors and Nicotinic Cholinergic Mechanisms of the Central Nervous System
Dani, J. A., & Bertrand, D. (2007) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.47.120505.105214 · Cited by 1,197 · see citing works
Neuronal nicotinic receptors: from structure to pathology
Gotti, C., & Clementi, F. (2004) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2004.09.006 · Cited by 970 · see citing works
Gene-targeting studies of mammalian behavior: is it the mutation or the background genotype?
Gerlai, R. (1996) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)20020-7 · Cited by 881 · see citing works
Neuronal nicotinic receptors in the human brain
Paterson, D., & Nordberg, A. K. (2000) · Progress in Neurobiology · doi:10.1016/s0301-0082(99)00045-3 · Cited by 782 · see citing works
Nicotinic Receptors in the Development and Modulation of CNS Synapses
Role, L. W., & Berg, D. K. (1996) · Neuron · doi:10.1016/s0896-6273(00)80134-8 · Cited by 762 · see citing works
Nicotinic acetylcholine involvement in cognitive function in animals
Levin, E. D., & Simon, B. B. (1998) · Psychopharmacology · doi:10.1007/s002130050667 · Cited by 675 · see citing works
Klink, R., d'Exaerde, A. D. K., Zoli, M., & Changeux, J.-P. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-05-01452.2001 · Cited by 674 · see citing works
Self-citationNicotine reinforcement and cognition restored by targeted expression of nicotinic receptors
Maskos, U., Molles, B. E., Pons, S., Besson, M., Guiard, B. P., Guilloux, J.-P., Evrard, A., Cazala, P., Cormier, A., Mameli-Engvall, M., et al. (2005) · Nature · doi:10.1038/nature03694 · Cited by 566 · see citing works
Self-citationDifferential regulation of neocortical synapses by neuromodulators and activity
Gil, Z., Connors, B. W., & Amitai, Y. (1997) · Neuron · doi:10.1016/s0896-6273(00)80380-3 · Cited by 553 · see citing works
Jensen, A. A., Frølund, B., Liljefors, T., & Krogsgaard‐Larsen, P. (2005) · Journal of Medicinal Chemistry · doi:10.1021/jm040219e · Cited by 541 · see citing works
Reduced antinociception in mice lacking neuronal nicotinic receptor subunits
Marubio, L. M., Jiménez, M. D. M. A., Cordero‐Erausquin, M., Léna, C., Novère, N. G. L., d’Exaerde, A. D. K., Huchet, M., Damaj, M. I., & Changeux, J. (1999) · Nature · doi:10.1038/19756 · Cited by 533 · see citing works
Self-citationNicotinic acetylcholine receptors: from structure to brain function
Hogg, R. C., Raggenbass, M., & Bertrand, D. (2003) · Springer eBooks · doi:10.1007/s10254-003-0005-1 · Cited by 529 · see citing works
Champtiaux, N., Gotti, C., Cordero‐Erausquin, M., David, D. J. P., Przybylski, C., Léna, C., Clementi, F., Moretti, M., Rossi, F., Novère, N. G. L., et al. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-21-07820.2003 · Cited by 505 · see citing works
Self-citationOrr‐Urtreger, A., Göldner, F. M., Saeki, M., Lorenzo, I., Goldberg, L. B., Biasi, M. D., Dani, J. A., Patrick, J. W., & Beaudet, A. L. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-23-09165.1997 · Cited by 494 · see citing works
Effect of nicotine and nicotinic receptors on anxiety and depression
Picciotto, M. R., Brunzell, D. H., & Caldarone, B. J. (2002) · Neuroreport · doi:10.1097/00001756-200207020-00006 · Cited by 483 · see citing works
Self-citationNicotine addiction and nicotinic receptors: lessons from genetically modified mice
Changeux, J.-P. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2849 · Cited by 453 · see citing works
Self-citationPICCIOTTO, M., ADDY, N., MINEUR, Y., & BRUNZELL, D. (2008) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2007.12.005 · Cited by 451 · see citing works
Self-citationNicotinic receptors in the brain: correlating physiology with function
Jones, S., Sudweeks, S. N., & Yakel, J. L. (1999) · Trends in Neurosciences · doi:10.1016/s0166-2236(99)01471-x · Cited by 447 · see citing works
Nicotinic acetylcholine receptors in health and disease
Lindstrom, J. (1997) · Molecular Neurobiology · doi:10.1007/bf02740634 · Cited by 443 · see citing works
Neuronal Nicotinic Acetylcholine Receptors as Targets for Drug Discovery
Holladay, M. W., Dart, M. J., & Lynch, J. K. (1997) · Journal of Medicinal Chemistry · doi:10.1021/jm970377o · Cited by 442 · see citing works
Nicotine Decreases Food Intake Through Activation of POMC Neurons
Mineur, Y. S., Abizaid, A., Rao, Y., Salas, R., DiLeone, R. J., Gündisch, D., Diano, S., De Biasi, M., Horvath, T. L., Gao, X.-B., et al. (2011) · Science · doi:10.1126/science.1201889 · Cited by 439 · see citing works
Self-citationAllosteric Receptors after 30 Years
Changeux, J., & Edelstein, S. J. (1998) · Neuron · doi:10.1016/s0896-6273(00)80616-9 · Cited by 426 · see citing works
Self-citationNeural mechanisms underlying nicotine addiction: acute positive reinforcement and withdrawal
S. Watkins, G. F. K. (2000) · Nicotine & Tobacco Research · doi:10.1080/14622200050011277 · Cited by 424 · see citing works
Günther, U., Benson, J. A., Benke, D., Fritschy, J., Reyes, G., Knoflach, F., Crestani, F., Aguzzi, A., Arigoni, M., Lang, Y., et al. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.17.7749 · Cited by 423 · see citing works
Le Novère, N., Corringer, P., & Changeux, J. (2002) · Journal of Neurobiology · doi:10.1002/neu.10153 · Cited by 411 · see citing works
Self-citationSalminen, O., Murphy, K. L., McIntosh, J. M., Drago, J., Marks, M. J., Collins, A. C., & Grady, S. R. (2004) · Molecular Pharmacology · doi:10.1124/mol.65.6.1526 · Cited by 401 · see citing works
Identification of Four Classes of Brain Nicotinic Receptors Using β2 Mutant Mice
Zoli, M., Léna, C., Picciotto, M. R., & Changeux, J. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-12-04461.1998 · Cited by 401 · see citing works
Self-citationLe Novere, N., Zoli, M., & Changeux, J. (1996) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1996.tb01206.x · Cited by 385 · see citing works
Self-citationNeuronal Nicotinic Acetylcholine Receptors
Lindstrom, J. (1996) · Springer eBooks · doi:10.1007/978-1-4899-1775-1_10 · Cited by 382 · see citing works
Sculpting Neural Circuits by Axon and Dendrite Pruning
Riccomagno, M. M., & Kolodkin, A. L. (2015) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100913-013038 · Cited by 366 · see citing works
Wooltorton, J. R. A., Pidoplichko, V. I., Broide, R. S., & Dani, J. A. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-08-03176.2003 · Cited by 363 · see citing works
Chronic Exposure to Nicotine Upregulates the Human α4β2 Nicotinic Acetylcholine Receptor Function
Buisson, B., & Bertrand, D. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-06-01819.2001 · Cited by 361 · see citing works
Nicotinic receptors in the brain. Links between molecular biology and behavior
Picciotto, M. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00146-3 · Cited by 354 · see citing works
Self-citationBansal, A., Singer, J. H., Hwang, B. J., Xu, W., Beaudet, A., & Feller, M. B. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-20-07672.2000 · Cited by 350 · see citing works
Methods of Behavior Analysis in Neuroscience
(2000) · CRC Press eBooks · doi:10.1201/9781420041811 · Cited by 345 · see citing works
Brain nicotinic receptors: structure and regulation, role in learning and reinforcement
Changeux, J.-P., Bertrand, D., Corringer, P.-J., Dehaene, S., Edelstein, S., Léna, C., Le Novère, N., Marubio, L., Picciotto, M., & Zoli, M. (1998) · Brain Research Reviews · doi:10.1016/s0165-0173(97)00040-4 · Cited by 322 · see citing works
Self-citationPons, S., Fattore, L., Cossu, G., Tolu, S., Porcu, E., McIntosh, J. M., Changeux, J. P., Maskos, U., & Fratta, W. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.3918-08.2008 · Cited by 312 · see citing works
Self-citationNeuronal Nicotinic Acetylcholine Receptors as Novel Drug Targets
Lloyd, G. K., & Williams, M. J. (2000) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)35314-5 · Cited by 311 · see citing works
Neurobiology of the nicotine withdrawal syndrome
Kenny, P. J., & Markou, A. (2001) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(01)00651-7 · Cited by 310 · see citing works
Chen, C., & Tonegawa, S. (1997) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.20.1.157 · Cited by 300 · see citing works
Paylor, R., Nguyen, M., Crawley, J. N., Patrick, J., Beaudet, A., & Orr-Urtreger, A. (1998) · Learning & Memory · doi:10.1101/lm.5.4.302 · Cited by 298 · see citing works
Hierarchical Control of Dopamine Neuron-Firing Patterns by Nicotinic Receptors
Mameli-Engvall, M., Evrard, A., Pons, S., Maskos, U., Svensson, T. H., Changeux, J.-P., & Faure, P. (2006) · Neuron · doi:10.1016/j.neuron.2006.05.007 · Cited by 296 · see citing works
Self-citationNicotinic receptor function: new perspectives from knockout mice
Cordero‐Erausquin, M., Marubio, L. M., Klink, R., & Changeux, J. (2000) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(00)01489-9 · Cited by 293 · see citing works
Self-citationlynx1, an Endogenous Toxin-like Modulator of Nicotinic Acetylcholine Receptors in the Mammalian CNS
Miwa, J. M., Ibáñez-Tallon, I., Crabtree, G. W., Sánchez, R., Šali, A., Role, L. W., & Heintz, N. (1999) · Neuron · doi:10.1016/s0896-6273(00)80757-6 · Cited by 287 · see citing works
Xu, W., Orr‐Urtreger, A., Nigro, F., Gelber, S. E., Sutcliffe, C. B., Armstrong, D. L., Patrick, J. W., Role, L. W., Beaudet, A. L., & Biasi, M. D. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-21-09298.1999 · Cited by 283 · see citing works
Cognitive Effects of Nicotine: Recent Progress
Valentine, G. W., & Sofuoglu, M. (2017) · Current Neuropharmacology · doi:10.2174/1570159x15666171103152136 · Cited by 280 · see citing works
Acetylcholine receptors and myasthenia
Lindstrom, J. M. (2000) · Muscle & Nerve · doi:10.1002/(sici)1097-4598(200004)23:4 · Cited by 277 · see citing works
Developmental mechanisms of topographic map formation and alignment
Cang, J., & Feldheim, D. A. (2013) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-062012-170341 · Cited by 275 · see citing works
Huberman, A. D., Manu, M., Koch, S. M., Susman, M. W., Lutz, A. B., Ullian, E. M., Baccus, S. A., & Barres, B. A. (2008) · Neuron · doi:10.1016/j.neuron.2008.07.018 · Cited by 271 · see citing works
Nicotine Induces Glutamate Release from Thalamocortical Terminals in Prefrontal Cortex
Lambe, E. K., Picciotto, M. R., & Aghajanian, G. K. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300032 · Cited by 261 · see citing works
Self-citationEvidence for enhanced neurobehavioral vulnerability to nicotine during periadolescence in rats
Adriani, W., Spijker, S., Deroche-Gamonet, V., Laviola, G., Le Moal, M., Smit, A. B., & Piazza, P. V. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-11-04712.2003 · Cited by 257 · see citing works
Nicotine and brain development
Dwyer, J. B., Broide, R. S., & Leslie, F. M. (2008) · Birth Defects Research Part C: Embryo Today: Reviews · doi:10.1002/bdrc.20118 · Cited by 256 · see citing works
Nicotine addiction: the possible role of functional upregulation
Buisson, B., & Bertrand, D. (2002) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(00)01979-9 · Cited by 254 · see citing works
The subtypes of nicotinic acetylcholine receptors on dopaminergic terminals of mouse striatum
Grady, S. R., Salminen, O., Laverty, D. C., Whiteaker, P., McIntosh, J. M., Collins, A. C., & Marks, M. J. (2007) · Biochemical Pharmacology · doi:10.1016/j.bcp.2007.07.032 · Cited by 252 · see citing works
Rossi, F., Pizzorusso, T., Porciatti, V., Marubio, L. M., Maffei, L., & Changeux, J. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.101120998 · Cited by 246 · see citing works
Self-citationCastañé, A., Valjent, E., Ledent, C. A., Parmentier, M., Maldonado, R. J., & Valverde, O. (2002) · Neuropharmacology · doi:10.1016/s0028-3908(02)00118-1 · Cited by 240 · see citing works
Computerized video analysis of social interactions in mice
de Chaumont, F., Coura, R., Serreau, P., Cressant, A., Chabout, J., Granon, S., & Olivo‐Marín, J. (2012) · Nature Methods · doi:10.1038/nmeth.1924 · Cited by 238 · see citing works
Kuryatov, A., Gerzanich, V., Nelson, M. E., Olale, F., & Lindstrom, J. M. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-23-09035.1997 · Cited by 227 · see citing works
Salas, R., Pieri, F., & De Biasi, M. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.1939-04.2004 · Cited by 226 · see citing works
New insights into the genetics of addiction
Li, M. D., & Burmeister, M. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2536 · Cited by 226 · see citing works
Human α6 AChR subtypes: subunit composition, assembly, and pharmacological responses
Kuryatov, A., Olale, F., Cooper, J., Choi, C. H., & Lindstrom, J. M. (2000) · Neuropharmacology · doi:10.1016/s0028-3908(00)00144-1 · Cited by 223 · see citing works
Picciotto, M. R., Caldarone, B. J., Brunzell, D. H., Zachariou, V., Stevens, T. R., & King, S. L. (2001) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(01)00161-9 · Cited by 221 · see citing works
Self-citationRole of Ca2+Ions in Nicotinic Facilitation of GABA Release in Mouse Thalamus
Léna, C., & Changeux, J. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-02-00576.1997 · Cited by 218 · see citing works
Self-citationBauman, M. L. (2006) · Johns Hopkins University Press eBooks · doi:10.1353/book.3225 · Cited by 215 · see citing works
Cui, C., Booker, T. K., Allen, R. S., Grady, S. R., Whiteaker, P., Marks, M. J., Salminen, O., Tritto, T., Butt, C. M., Allen, W. R., et al. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-35-11045.2003 · Cited by 213 · see citing works
Picciotto, M. R. (2007) · Frontiers in bioscience · doi:10.2741/2695 · Cited by 212 · see citing works
Self-citationGrubb, M. S., Rossi, F. M., Changeux, J.-P., & Thompson, I. D. (2003) · Neuron · doi:10.1016/s0896-6273(03)00789-x · Cited by 208 · see citing works
Self-citationJackson, K. J., Martin, B. R., Changeux, J. P., & Damaj, M. I. (2008) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.107.132977 · Cited by 208 · see citing works
Self-citationNicotinic receptors in aging and dementia
Picciotto, M. R., & Zoli, M. (2002) · Journal of Neurobiology · doi:10.1002/neu.10102 · Cited by 207 · see citing works
Self-citationWalters, C. L., Brown, S., Changeux, J.-P., Martin, B., & Damaj, M. I. (2006) · Psychopharmacology · doi:10.1007/s00213-005-0295-x · Cited by 206 · see citing works
Self-citationIncreased neurodegeneration during ageing in mice lacking high‐affinity nicotine receptors
Zoli, M., Picciotto, M. R., Ferrari, R., Cocchi, D., & Changeux, J. (1999) · The EMBO Journal · doi:10.1093/emboj/18.5.1235 · Cited by 206 · see citing works
Self-citationRoss, S. A., Wong, J. Y. F., Clifford, J. J., Kinsella, A., Massalas, J. S., Horne, M. K., Scheffer, I. E., Kola, I., Waddington, J. L., Berkovic, S. F., et al. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-17-06431.2000 · Cited by 204 · see citing works
Benowitz, N. L. (1999) · Primary Care Clinics in Office Practice · doi:10.1016/s0095-4543(05)70120-2 · Cited by 203 · see citing works
Moser, N., Mechawar, N., Jones, I. W., Gochberg-Sarver, A., Orr‐Urtreger, A., Plomann, M., Salas, R., Molles, B. E., Marubio, L. M., Roth, U., et al. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04498.x · Cited by 197 · see citing works
Self-citationSudweeks, S. N., & Yakel, J. L. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.00515.x · Cited by 197 · see citing works
Arias, H. R. (2000) · Neurochemistry International · doi:10.1016/s0197-0186(99)00154-0 · Cited by 193 · see citing works
Li, M. D., Beuten, J., Ma, J. Z., Payne, T. J., Lou, X., Garcia, V., Duenes, A. S., Crews, K. M., & Elston, R. C. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi132 · Cited by 187 · see citing works
A hierarchical neuronal network for planning behavior
Dehaene, S., & Changeux, J. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.24.13293 · Cited by 187 · see citing works
Self-citationCholinergic modulation of cognitive processing: insights drawn from computational models
Newman, E. L., Gupta, K., Climer, J. R., Monaghan, C. K., & Hasselmo, M. E. (2012) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2012.00024 · Cited by 185 · see citing works
Using Knockout and Transgenic Mice to Study Neurophysiology and Behavior
Picciotto, M. R., & Wickman, K. (1998) · Physiological Reviews · doi:10.1152/physrev.1998.78.4.1131 · Cited by 185 · see citing works
Self-citationHuman α4β2 Neuronal Nicotinic Acetylcholine Receptor in HEK 293 Cells: A Patch-Clamp Study
Buisson, B., Gopalakrishnan, M., Arnerić, S. P., Sullivan, J. P., & Bertrand, D. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-24-07880.1996 · Cited by 183 · see citing works
Nicotine reverses hypofrontality in animal models of addiction and schizophrenia
Koukouli, F., Rooy, M., Tziotis, D., Sailor, K. A., O’Neill, H. C., Levenga, J., Witte, M., Nilges, M., Changeux, J., Hoeffer, C. A., et al. (2017) · Nature Medicine · doi:10.1038/nm.4274 · Cited by 182 · see citing works
Self-citationRegulation of synaptic transmission and plasticity by neuronal nicotinic acetylcholine receptors
McKay, B. E., Placzek, A. N., & Dani, J. A. (2007) · Biochemical Pharmacology · doi:10.1016/j.bcp.2007.07.001 · Cited by 181 · see citing works
Diversity and distribution of nicotinic acetylcholine receptors in the locus ceruleus neurons
Léna, C., d’Exaerde, A. D. K., Cordero‐Erausquin, M., Novère, N. G. L., Jiménez, M. D. M. A., & Changeux, J. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.21.12126 · Cited by 181 · see citing works
Self-citationNicotinic receptors in human brain: topography and pathology
Court, J. A., Martin-Ruiz, C., Graham, A., & Perry, E. (2000) · Journal of Chemical Neuroanatomy · doi:10.1016/s0891-0618(00)00110-1 · Cited by 180 · see citing works
Synaptic Currents Generated by Neuronal Acetylcholine Receptors Sensitive to α-Bungarotoxin
Zhang, Z., Coggan, J. S., & Berg, D. K. (1996) · Neuron · doi:10.1016/s0896-6273(00)80253-6 · Cited by 180 · see citing works
Molecular Mechanisms Underlying Behaviors Related to Nicotine AddictionPreprint
Picciotto, M. R., & Kenny, P. J. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a012112 · Cited by 178 · see citing works
Self-citationBiological Aspects of the Link between Smoking and Depression
Quattrocki, E., Baird, A., & Yurgelun-Todd, D. (2000) · Harvard Review of Psychiatry · doi:10.1080/hrp_8.3.99 · Cited by 176 · see citing works
Central nicotinic receptors, neurotrophic factors and neuroprotection
Belluardo, N., Mudò, G., Blum, M., & Fuxé, K. (2000) · Behavioural Brain Research · doi:10.1016/s0166-4328(00)00197-2 · Cited by 176 · see citing works
Neuronal nicotinic receptors: from structure to function
Bertrand, D. (2001) · Nicotine & Tobacco Research · doi:10.1080/14622200110050213 · Cited by 175 · see citing works
Olale, F., Gerzanich, V., Kuryatov, A., Wang, F., & Lindstrom, J. M. (1997) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37064-8 · Cited by 174 · see citing works
5-Iodo-A-85380, an α4β2 Subtype-Selective Ligand for Nicotinic Acetylcholine Receptors
Mukhin, A. G., Gündisch, D., Horti, A. G., Koren, A. O., Tamagnan, G., Kimes, A. S., Chambers, J., Vaupel, D. B., King, S. L., Picciotto, M. R., et al. (2000) · Molecular Pharmacology · doi:10.1124/mol.57.3.642 · Cited by 173 · see citing works
Self-citationPimlott, S. L., Piggott, M. A., Owens, J., Greally, E., COURT, J. A., Jaros, E., Perry, R. H., Perry, E. K., & Wyper, D. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300302 · Cited by 170 · see citing works
Executive and social behaviors under nicotinic receptor regulation
Granon, S., Fauré, P., & Changeux, J. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1533498100 · Cited by 166 · see citing works
Self-citationNicotine, Brain Nicotinic Receptors, and Neuropsychiatric Disorders
Mihailescu, S., & Drucker-Colı́n, R. (2000) · Archives of Medical Research · doi:10.1016/s0188-4409(99)00087-9 · Cited by 162 · see citing works
Exley, R., Maubourguet, N., David, V., Eddine, R., Evrard, A., Pons, S., Marti, F., Threlfell, S., Cazala, P., McIntosh, J. M., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1103000108 · Cited by 159 · see citing works
Self-citationStafford, B. K., Sher, A., Litke, A. M., & Feldheim, D. A. (2009) · Neuron · doi:10.1016/j.neuron.2009.09.021 · Cited by 156 · see citing works
Grady, S. R., Meinerz, N. M., Cao, J., Reynolds, A. M., Picciotto, M. R., Changeux, J., McIntosh, J. M., Marks, M. J., & Collins, A. C. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00019.x · Cited by 156 · see citing works
Self-citation
- Authors
- Picciotto, M. R., Zoli, M., Léna, C., Bessis, A., Lallemand, Y., LeNovère, N., Vincent, P., Pich, E. M., Brûlet, P., & Changeux, J.-P.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Venue
- Nature
- Published
- 1995-03
- Volume
- 374
- Issue
- 6517
- Pages
- 65-67
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W1996157865
- Cited by
- 668
- References
- 26
- Citations by year
- 2026: 2 · 2025: 4 · 2023: 9 · 2022: 27 · 2021: 8 · 2020: 15 · 2019: 12 · 2018: 10 · 2017: 12 · 2016: 17 · 2015: 16 · 2014: 18 · 2013: 20 · 2012: 27
- FWCI
- 10.67
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Keywords
- nicotinic acetylcholine receptors, beta2 subunit, avoidance learning, passive avoidance, associative memory, thalamic neurons, nicotine binding, gene targeting
- MeSH terms
- Animals, Avoidance Learning, Base Sequence, Brain, Cell Line, DNA, Female, Homozygote, Hypothalamus, Male, Mice, Inbred C57BL, Mice, Inbred DBA, Molecular Sequence Data, Mutation, Nicotine, Receptors, Nicotinic, Patch-Clamp Techniques, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
