Cited by 203Hypothalamic control of reproductive hormonesGrowth Hormone and Insulin-like Growth FactorsPituitary Gland Disorders and Treatments

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Anterior Pituitary Hypoplasia and Dwarfism in Mice Lacking the Dopamine Transporter

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Bossé, Roger, Fumagalli, Fabio, Jaber, Mohamed, Giros, Bruno, Gainetdinov, Raul R, Wetsel, William C, Missale, Cristina, Caron, Marc G·1997·Neuron

DOI 10.1016/s0896-6273(00)80353-0

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Abstract

Deletion of the dopamine transporter (DAT) results in increased dopaminergic tone, anterior pituitary hypoplasia, dwarfism, and an inability to lactate. DAT elimination alters the spatial distribution and dramatically reduces the numbers of lactotrophs and somatotrophs in the pituitary. Despite having normal circulating levels of growth hormone and prolactin in blood, hypoplastic glands from DAT-/- mice fail to respond to secretagog stimulation. The effects of DAT deletion on pituitary function result from elevated DA levels that down-regulate the lactotroph D2 DA receptors and depress hypothalamic growth hormone-releasing hormone content. These results reveal an unexpected and important role or DA in the control of developmental events in the pituitary gland and assign a critical role for hypothalamic DA reuptake in regulating these events.

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Authors: Bossé, R., Fumagalli, F., Jaber, M., Giros, B., Gainetdinov, R. R., Wetsel, W. C., Missale, C., & Caron, M. G.
Affiliations: Howard Hughes Medical Institute (US)
Duke Medical Center (US)
Corresponding author: Caron, Marc G
ORCID: Fumagalli, Fabio
Jaber, Mohamed
Gainetdinov, Raul R
Wetsel, William C
Missale, Cristina
Caron, Marc G
Venue: Neuron
Publisher: Elsevier BV
Published: 1997-07
Volume: 19
Issue: 1
Pages: 127-138
ISSN: 0896-6273 (ISSN-L)
DOI: 10.1016/s0896-6273(00)80353-0
OpenAlex: W1990625891
Cited by: 203
References: 60
Citations by year: 2026: 2 · 2025: 2 · 2024: 1 · 2023: 2 · 2022: 3 · 2021: 4 · 2020: 4 · 2019: 4 · 2018: 4 · 2017: 6 · 2016: 5 · 2015: 4 · 2014: 5 · 2013: 9 · 2012: 8
FWCI: 10.42
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 5860 d)
Locations: Neuron (publishedVersion)
PubMed (publishedVersion)
Institutional Research Information System (Università degli Studi di Brescia) (submittedVersion)
Topics: Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
Keywords: dopamine transporter, anterior pituitary hypoplasia, dwarfism, lactotrophs, somatotrophs, growth hormone, prolactin, dopamine D2 receptor, growth hormone-releasing hormone, hypothalamus, lactation, pituitary development, dopamine reuptake
MeSH terms: Animals, Carrier Proteins, Dopamine, Dwarfism, Hypothalamus, Membrane Glycoproteins, Mice, Mutant Strains, Nerve Tissue Proteins, Pituitary Diseases, Pituitary Gland, Anterior, In Situ Hybridization, Membrane Transport Proteins, Dopamine Plasma Membrane Transport Proteins, Mice

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Anterior Pituitary Hypoplasia and Dwarfism in Mice Lacking the Dopamine Transporter

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