The DOI matches its Crossref record; 58 of the 60 references it cites were found in a registry or an index.
Anterior Pituitary Hypoplasia and Dwarfism in Mice Lacking the Dopamine Transporter
Open accessAbstract
Deletion of the dopamine transporter (DAT) results in increased dopaminergic tone, anterior pituitary hypoplasia, dwarfism, and an inability to lactate. DAT elimination alters the spatial distribution and dramatically reduces the numbers of lactotrophs and somatotrophs in the pituitary. Despite having normal circulating levels of growth hormone and prolactin in blood, hypoplastic glands from DAT-/- mice fail to respond to secretagog stimulation. The effects of DAT deletion on pituitary function result from elevated DA levels that down-regulate the lactotroph D2 DA receptors and depress hypothalamic growth hormone-releasing hormone content. These results reveal an unexpected and important role or DA in the control of developmental events in the pituitary gland and assign a critical role for hypothalamic DA reuptake in regulating these events.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The excess dopamine is dispersed by blood flow, reaches the pituitary, and retards growth in these animals.”
From Effects of Stimulant Medication on Growth Rates Across 3 Years in the MTA Follow-up (2007) · cites this paper as Bosse et al., 1997
In the citing paper
“Studies of mice (Bosse et al., 1997) that lack the dopamine transporter show that high levels of dopamine occur in the hypothalamus as well as the striatum.”
From Effects of Stimulant Medication on Growth Rates Across 3 Years in the MTA Follow-up (2007) · cites this paper as Bosse et al., 1997
Citations
Cites
Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction
Chomczynski, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1006/abio.1987.9999 · Cited by 65,515
Fraker, P. J., & Speck, J. C. (1978) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(78)91322-0 · Cited by 4,553
Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter
Giros, B., Jaber, M., Jones, S. R., Wightman, R. M., & Caron, M. G. (1996) · Nature · doi:10.1038/379606a0 · Cited by 2,476
Self-citationGrowth Hormone-Releasing Factor from a Human Pancreatic Tumor That Caused Acromegaly
Guillemin, R., Brazeau, P., Böhlen, P., Esch, F. S., LING, N. C., & Wehrenberg, W. B. (1982) · Science · doi:10.1126/science.6812220 · Cited by 1,292
Li, S., Crenshaw, E. B., Rawson, E. J., Simmons, D. M., Swanson, L. W., & Rosenfeld, M. G. (1990) · Nature · doi:10.1038/347528a0 · Cited by 1,196
Characterization of a growth hormone-releasing factor from a human pancreatic islet tumour
Rivier, J., Spiess, J., Thorner, M. O., & Vale, W. (1982) · Nature · doi:10.1038/300276a0 · Cited by 1,102
Neurotransmitter Transporters: Recent Progress
Amara, S., & Kuhar, M. J. (1993) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.16.030193.000445 · Cited by 1,088
A tissue-specific transcription factor containing a homeodomain specifies a pituitary phenotype
Ingraham, H. A., Chen, R., Mangalam, H. J., Elsholtz, H. P., Flynn, S. E., Lin, C. R., Simmons, D. M., Swanson, L. W., & Rosenfeld, M. G. (1988) · Cell · doi:10.1016/0092-8674(88)90038-4 · Cited by 978
Sornson, M. W., Wu, W., Dasen, J. S., Flynn, S. E., Norman, D. J., O’Connell, S. M., Gukovsky, I., Carrière, C., Ryan, A. K., Miller, A. P., et al. (1996) · Nature · doi:10.1038/384327a0 · Cited by 786
Dopamine: A Prolactin-Inhibiting Hormone*
Ben‐Jonathan, N. (1985) · Endocrine Reviews · doi:10.1210/edrv-6-4-564 · Cited by 739
Research works printed but not linked: 2
- Elsholtz, 1991, Inhibitory control of prolactin and Pit-1/GHF1 gene promoters by dopamine, Proc. Natl. Acad. Sci. USA, 266, 22919
- Fumagalli, 1996, Expression of mRNA coding for the serotonin transporter in aged vs, young brain, 719, 225
Cited by
Sorted by citations
Prolactin: structure, function, and regulation of secretion
Freeman, M. E., Kanyicska, B., Lerant, A., & Nagy, G. (2000) · Physiological Reviews · doi:10.1152/physrev.2000.80.4.1523 · Cited by 2,457
Dopamine as a Prolactin (PRL) Inhibitor
Ben-Jonathan, N., & Hnasko, R. (2001) · Endocrine Reviews · doi:10.1210/edrv.22.6.0451 · Cited by 983
Role of Serotonin in the Paradoxical Calming Effect of Psychostimulants on Hyperactivity
Gainetdinov, R. R., Wetsel, W. C., Jones, S. R., Levin, E. D., Jaber, M., & Caron, M. G. (1999) · Science · doi:10.1126/science.283.5400.397 · Cited by 885
Self-citationDopaminergic Role in Stimulant-Induced Wakefulness
Wisor, J. P., Nishino, S., Sora, I., Uhl, G. R., Mignot, E. J.-M., & Edgar, D. M. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-05-01787.2001 · Cited by 779
Neuroendocrine Control of Growth Hormone Secretion
Müller, E. E., Locatelli, V., & Cocchi, D. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.2.511 · Cited by 635
Metadata
- Authors
- Bossé, R., Fumagalli, F., Jaber, M., Giros, B., Gainetdinov, R. R., Wetsel, W. C., Missale, C., & Caron, M. G.
- Affiliations
- Howard Hughes Medical Institute (US)
- Duke Medical Center (US)
- Corresponding author
- Caron, Marc G
- ORCID
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 1997-07
- Volume
- 19
- Issue
- 1
- Pages
- 127-138
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W1990625891
- Cited by
- 203
- References
- 60
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 1 · 2023: 2 · 2022: 3 · 2021: 4 · 2020: 4 · 2019: 4 · 2018: 4 · 2017: 6 · 2016: 5 · 2015: 4 · 2014: 5 · 2013: 9 · 2012: 8
- FWCI
- 10.42
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Institutional Research Information System (Università degli Studi di Brescia) (submittedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
- Keywords
- dopamine transporter, anterior pituitary hypoplasia, dwarfism, lactotrophs, somatotrophs, growth hormone, prolactin, dopamine D2 receptor, growth hormone-releasing hormone, hypothalamus, lactation, pituitary development, dopamine reuptake
- MeSH terms
- Animals, Carrier Proteins, Dopamine, Dwarfism, Hypothalamus, Membrane Glycoproteins, Mice, Mutant Strains, Nerve Tissue Proteins, Pituitary Diseases, Pituitary Gland, Anterior, In Situ Hybridization, Membrane Transport Proteins, Dopamine Plasma Membrane Transport Proteins, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
