The DOI matches its Crossref record; 82 of the 82 references it cites were found in a registry or an index.
Mice Deficient in Golf Are Anosmic
Open accessAbstract
We have used gene targeting to examine the role of the G alpha subunit, G(olf), in olfactory signal transduction. Mice homozygous for a null mutation in G(olf) show a striking reduction in the electrophysiological response of primary olfactory sensory neurons to a wide variety of odors. Despite this profound diminution in response to odors, the topographic map of primary sensory projections to the olfactory bulb remains unaltered in G(olf) mutants. Greater than 75% of the G(olf) mutant mice are unable to nurse and die within 2 days after birth. Rare surviving homozygotes mate and are fertile, but mutant females exhibit inadequate maternal behaviors. Surviving homozygous mutant mice also exhibit hyperactive behaviors. These behavioral phenotypes, taken together with the patterns of G(olf) expression, suggest that G(olf) is required for olfactory signal transduction and may also function as an essential signaling molecule more centrally in the brain.
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Cited by
Atypical Membrane Topology and Heteromeric Function of Drosophila Odorant Receptors In Vivo
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Odorant Receptors Govern the Formation of a Precise Topographic Map
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Self-citationIdentification of Ligands for Olfactory Receptors by Functional Expression of a Receptor Library
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Spatial Representation of the Glomerular Map in the Drosophila Protocerebrum
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Metadata
- Authors
- Belluscio, L., Gold, G. H., Nemes, A., & Axel, R.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 1998-01
- Volume
- 20
- Issue
- 1
- Pages
- 69-81
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2018348038
- Cited by
- 565
- References
- 82
- FWCI
- 14.82
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
