The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
Tissue Plasminogen Activator Contributes to the Late Phase of LTP and to Synaptic Growth in the Hippocampal Mossy Fiber Pathway
Open accessAbstract
The expression of tissue plasminogen activator (tPA) is increased during activity-dependent forms of synaptic plasticity. We have found that inhibitors of tPA inhibit the late phase of long-term potentiation (L-LTP) induced by either forskolin or tetanic stimulation in the hippocampal mossy fiber and Schaffer collateral pathways. Moreover, application of tPA enhances L-LTP induced by a single tetanus. Exposure of granule cells in culture to forskolin results in secretion of tPA, elongation of mossy fiber axons, and formation of new, active presynaptic varicosities contiguous to dendritic clusters of the glutamate receptor R1. These structural changes are blocked by tPA inhibitors and induced by application of tPA. Thus, tPA may be critically involved in the production of L-LTP and specifically in synaptic growth.
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Metadata
- Authors
- Baranes, D., Lederfein, D., Huang, Y.-Y., Chen, M., Bailey, C. H., & Kandel, E. R.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 1998-10
- Volume
- 21
- Issue
- 4
- Pages
- 813-825
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W1983277257
- Cited by
- 405
- References
- 52
- FWCI
- 6.26
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Tissue Plasminogen Activator Contributes to the Late Phase of LTP and to Synaptic Growth in the Hippocampal Mossy Fiber Pathway. https://app.cochat.ai/papers/10.1016/s0896-6273(00)80597-8
- The paper
- Baranes, D., Lederfein, D., Huang, Y.-Y., Chen, M., Bailey, C. H., & Kandel, E. R. (1998). Tissue Plasminogen Activator Contributes to the Late Phase of LTP and to Synaptic Growth in the Hippocampal Mossy Fiber Pathway. Neuron. https://doi.org/10.1016/s0896-6273(00)80597-8
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
