Reelin, lipoprotein receptors and synaptic plasticity

Lipid rafts and signal transduction

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Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo

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Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.

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A protein related to extracellular matrix proteins deleted in the mouse mutant reeler

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CNS synaptogenesis promoted by glia-derived cholesterol

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APP Processing and Synaptic Function

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Regulation of NMDA receptor trafficking by amyloid-β

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Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease.

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Reeler/Disabled-like Disruption of Neuronal Migration in Knockout Mice Lacking the VLDL Receptor and ApoE Receptor 2

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Decrease in Reelin and Glutamic Acid Decarboxylase67 (GAD67) Expression in Schizophrenia and Bipolar Disorder

Guidotti, A., Auta, J., Davis, J. M., Gerevini, V. D. G., Dwivedi, Y., Grayson, D. R., Impagnatiello, F., Pandey, G. N., Pesold, C., Sharma, R. P., et al. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.11.1061 · Cited by 1,203 · see citing works

Cholesterol depletion inhibits the generation of β-amyloid in hippocampal neurons

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Amyloidogenic processing of the Alzheimer β-amyloid precursor protein depends on lipid rafts

Ehehalt, R., Keller, P., Haass, C., Thiele, C., & Simons, K. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200207113 · Cited by 1,107 · see citing works

Simvastatin strongly reduces levels of Alzheimer's disease β-amyloid peptides Aβ42 and Aβ40 in vitro and in vivo

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Glutamate and Schizophrenia: Beyond the Dopamine Hypothesis

Coyle, J. T. (2006) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-006-9062-8 · Cited by 917 · see citing works

Direct Binding of Reelin to VLDL Receptor and ApoE Receptor 2 Induces Tyrosine Phosphorylation of Disabled-1 and Modulates Tau Phosphorylation

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Apolipoprotein E4: A causative factor and therapeutic target in neuropathology, including Alzheimer’s disease

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Autosomal recessive lissencephaly with cerebellar hypoplasia is associated with human RELN mutations

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Apolipoprotein E associated with astrocytic glia of the central nervous system and with nonmyelinating glia of the peripheral nervous system.

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Reelin Is a Ligand for Lipoprotein Receptors

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Differential Effects of Apolipoproteins E3 and E4 on Neuronal Growth in Vitro

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Synaptic Efficacy Enhanced by Glial Cells in Vitro

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The medial ganglionic eminence gives rise to a population of early neurons in the developing cerebral cortex

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A decrease of reelin expression as a putative vulnerability factor in schizophrenia

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Reelin and brain development

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EphB Receptors Interact with NMDA Receptors and Regulate Excitatory Synapse Formation

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Lipoproteins and their receptors in the central nervous system. Characterization of the lipoproteins in cerebrospinal fluid and identification of apolipoprotein B,E(LDL) receptors in the brain.

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Neuronal position in the developing brain is regulated by mouse disabled-1

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Role of the Reelin Signaling Pathway in Central Nervous System Development

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Purkinje-cell-derived Sonic hedgehog regulates granule neuron precursor cell proliferation in the developing mouse cerebellum

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Neocortical histogenesis in normal and reeler mice: A developmental study based upon [3H]thymidine autoradiography

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Scrambler and yotari disrupt the disabled gene and produce a reeler -like phenotype in mice

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Reelin and ApoE receptors cooperate to enhance hippocampal synaptic plasticity and learning

Weeber, E. J., Beffert, U., Jones, C., Christian, J. M., Förster, E., Sweatt, J. D., & Herz, J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m205147200 · Cited by 623 · see citing works

Effects of secreted oligomers of amyloid β‐protein on hippocampal synaptic plasticity: a potent role for trimers

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Reelin promoter hypermethylation in schizophrenia

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Interaction of Cytosolic Adaptor Proteins with Neuronal Apolipoprotein E Receptors and the Amyloid Precursor Protein

Trommsdorff, M., Borg, J., Margolis, B. L., & Herz, J. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.50.33556 · Cited by 540 · see citing works

Two new mutants, ‘trembler’ and ‘reeler’, with neurological actions in the house mouse (Mus musculus L.)

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A role for apolipoprotein E, apolipoprotein A-I, and low density lipoprotein receptors in cholesterol transport during regeneration and remyelination of the rat sciatic nerve.

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A schizophrenia-associated mutation of DISC1 perturbs cerebral cortex development

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A LIS1/NUDEL/Cytoplasmic Dynein Heavy Chain Complex in the Developing and Adult Nervous System

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Modulation of NMDA Receptor- Dependent Calcium Influx and Gene Expression Through EphB Receptors

Takasu, M. A., Dalva, M. B., Zigmond, R. E., & Greenberg, M. E. (2002) · Science · doi:10.1126/science.1065983 · Cited by 497 · see citing works

Modulation of synaptic plasticity and memory by Reelin involves differential splicing of the lipoprotein receptor Apoer2

Beffert, U., Weeber, E. J., Durudas, A., Qiu, S., Masiulis, I., Sweatt, J. D., Li, W.-P., Adelmann, G., Frotscher, M., Hammer, R. E., et al. (2005) · Neuron · doi:10.1016/j.neuron.2005.07.007 · Cited by 497 · see citing works

NUDEL Is a Novel Cdk5 Substrate that Associates with LIS1 and Cytoplasmic Dynein

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A role for Cajal–Retzius cells and reelin in the development of hippocampal connections

Del Río, J. A., Heimrich, B., Borrell, V., Förster, E., Drakew, A., Alcántara, S., Nakajima, K., Miyata, T., Ogawa, M., Mikoshiba, K., et al. (1997) · Nature · doi:10.1038/385070a0 · Cited by 472 · see citing works

Lipoprotein receptors in the nervous system

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Interactions of the Low Density Lipoprotein Receptor Gene Family with Cytosolic Adaptor and Scaffold Proteins Suggest Diverse Biological Functions in Cellular Communication and Signal Transduction

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Reduction in Reelin immunoreactivity in hippocampus of subjects with schizophrenia, bipolar disorder and major depression

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Lis1 and doublecortin function with dynein to mediate coupling of the nucleus to the centrosome in neuronal migration

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An Extracellular Proteolytic Cascade Promotes Neuronal Degeneration in the Mouse Hippocampus

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Protein kinase C modulates NMDA receptor trafficking and gating

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Knockout of the cholesterol 24-hydroxylase gene in mice reveals a brain-specific mechanism of cholesterol turnover

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Time of origin of corresponding cell classes in the cerebral cortex of normal and reeler mutant mice: An autoradiographic analysis

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Reelin-induced tryosine phosphorylation of Disabled 1 during neuronal positioning

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Tissue Plasminogen Activator Contributes to the Late Phase of LTP and to Synaptic Growth in the Hippocampal Mossy Fiber Pathway

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Neurodegeneration in the Central Nervous System of apoE-Deficient Mice

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Anatomical, Physiological and biochemical studies of the cerebellum from reeler mutant mouse

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Apolipoprotein E fragments present in Alzheimer's disease brains induce neurofibrillary tangle-like intracellular inclusions in neurons

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Distribution of the ?2-macroglobulin receptor/low density lipoprotein receptor-related protein in human tissues

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Regulation of cytoplasmic dynein behaviour and microtubule organization by mammalian Lis1

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Reelin promotes hippocampal dendrite development through the VLDLR/ApoER2-Dab1 pathway

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Dopamine D1 Receptor-Dependent Trafficking of Striatal NMDA Glutamate Receptors to the Postsynaptic Membrane

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The Disabled 1 Phosphotyrosine-Binding Domain Binds to the Internalization Signals of Transmembrane Glycoproteins and to Phospholipids

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Isoform-specific effects of human apolipoprotein E on brain function revealed in <i>ApoE</i> knockout mice: Increased susceptibility of females

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Expression of Human Apolipoprotein E3 or E4 in the Brains ofApoe−/−Mice: Isoform-Specific Effects on Neurodegeneration

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Ndel1 Operates in a Common Pathway with LIS1 and Cytoplasmic Dynein to Regulate Cortical Neuronal Positioning

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Reelin Activates Src Family Tyrosine Kinases in Neurons

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The reeler gene encodes a protein with an EGF–like motif expressed by pioneer neurons

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Regulation of late-phase LTP and long-term memory in normal and aging hippocampus: role of secreted proteins tPA and BDNF

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The Receptor Tyrosine Kinase EphB2 Regulates NMDA-Dependent Synaptic Function

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Lipid- and receptor-binding regions of apolipoprotein E4 fragments act in concert to cause mitochondrial dysfunction and neurotoxicity

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Kinase-Independent Requirement of EphB2 Receptors in Hippocampal Synaptic Plasticity

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Reelin Deficiency and Displacement of Mature Neurons, But Not Neurogenesis, Underlie the Formation of Granule Cell Dispersion in the Epileptic Hippocampus

Heinrich, C., Nitta, N., Flubacher, A., Müller, M., Fahrner, A., Kirsch, M., Freiman, T. M., Suzuki, F., Depaulis, A., Frotscher, M., et al. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.5516-05.2006 · Cited by 307 · see citing works

Reelin-mediated Signaling Locally Regulates Protein Kinase B/Akt and Glycogen Synthase Kinase 3β

Beffert, U., Morfini, G., Bock, H. H., Reyna, H., Brady, S. T., & Herz, J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m209205200 · Cited by 306 · see citing works

Tissue plasminogen activator in the amygdala is critical for stress-induced anxiety-like behavior

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Reelin modulates NMDA receptor activity in cortical neurons

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Fyn Tyrosine Kinase Is a Critical Regulator of Disabled-1 during Brain Development

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Reelin signaling is impaired in autism

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Role of Tissue Plasminogen Activator Receptor LRP in Hippocampal Long-Term Potentiation

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Brain cholesterol turnover required for geranylgeraniol production and learning in mice

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Hippocampal plasticity requires postsynaptic ephrinBs

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Role for Reelin in the Development of Granule Cell Dispersion in Temporal Lobe Epilepsy

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Laminating the hippocampus

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The reelin receptor ApoER2 recruits JNK-interacting proteins-1 and -2

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Neuronal LRP1 Functionally Associates with Postsynaptic Proteins and Is Required for Normal Motor Function in Mice

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Reelin signals through apolipoprotein E receptor 2 and Cdc42 to increase growth cone motility and filopodia formation

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Review: Disruption of the Postsynaptic Density in Alzheimer’s Disease and Other Neurodegenerative Dementias

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Reelin regulates the maturation of dendritic spines, synaptogenesis and glial ensheathment of newborn granule cells

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APP interacts with LRP4 and Agrin to coordinate the development of the neuromuscular junction in mice

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Sex‐specific association of the reelin gene with bipolar disorder

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Cholesterol homeostasis failure in the brain: Implications for synaptic dysfunction and cognitive decline

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Targets of polyamine dysregulation in major depression and suicide: Activity-dependent feedback, excitability, and neurotransmission

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Differential splicing and glycosylation of Apoer2 alters synaptic plasticity and fear learning

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Sorting nexin 17 regulates ApoER2 recycling and reelin signaling

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The effect of aged microglia on synaptic impairment and its relevance in neurodegenerative diseases

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Impairment of cognitive performance after reelin knockdown in the medial prefrontal cortex of pubertal or adult rats

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Pathophysiological function of ADAMTS enzymes on molecular mechanism of Alzheimer’s disease

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Reelin proteolysis affects signaling related to normal synapse function and neurodegeneration

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The E3 ubiquitin ligase IDOL regulates synaptic ApoER2 levels and is important for plasticity and learning

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The cytoplasmic adaptor protein X11α and extracellular matrix protein Reelin regulate ApoE receptor 2 trafficking and cell movement

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Seizure-induced motility of differentiated dentate granule cells is prevented by the central Reelin fragment

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The Reelin (RELN) gene is associated with executive function in healthy individuals.

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A neuronal VLDLR variant lacking the third complement-type repeat exhibits high capacity binding of apoE containing lipoproteins

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Reciprocal Regulation of Very Low Density Lipoprotein Receptors (VLDLRs) in Neurons by Brain-derived Neurotrophic Factor (BDNF) and Reelin

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γ‐Secretase and metalloproteinase activity regulate the distribution of endoplasmic reticulum to hippocampal neuron dendritic spines

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Glutamatergic cerebellar granule neurons synthesize and secrete reelin in vitro

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Reelin Is a Ligand for Lipoprotein Receptors

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LRP3, an apolipoprotein receptor that links reelin signalling and APP expression, is affected in Alzheimer's diseasePreprint

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Functional Dissection of Reelin Signaling by Site-Directed Disruption of Disabled-1 Adaptor Binding to Apolipoprotein E Receptor 2: Distinct Roles in Development and Synaptic Plasticity

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Ephrin Bs are essential components of the Reelin pathway to regulate neuronal migration

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ApoER2 and VLDLR in the developing human telencephalon

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