The DOI matches its Crossref record; 61 of the 61 references it cites were found in a registry or an index.
Cysteine-Rich Domain Isoforms of the Neuregulin-1 Gene Are Required for Maintenance of Peripheral Synapses
Open accessAbstract
Neuregulin-1 (NRG-1) signaling has been implicated in inductive interactions between pre- and postsynaptic partners during synaptogenesis. We used gene targeting to selectively disrupt cysteine-rich domain-(CRD-) containing NRG-1 isoforms. In CRD-NRG-1-/-mice, peripheral projections defasciculated and displayed aberrant branching patterns within their targets. Motor nerve terminals were transiently associated with broad bands of postsynaptic ACh receptor (AChR) clusters. Initially, Schwann cell precursors accompanied peripheral projections, but later, Schwann cells were absent from axons in the periphery. Following initial stages of synapse formation, sensory and motor nerves withdrew and degenerated. Our data demonstrate the essential role of CRD-NRG-1-mediated signaling for coordinating nerve, target, and Schwann cell interactions in the normal maintenance of peripheral synapses, and ultimately in the survival of CRD-NRG-1-expressing neurons.
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A "DIRECT-COLORING" THIOCHOLINE METHOD FOR CHOLINESTERASES
KARNOVSKY, M. J., & ROOTS, L. (1964) · Journal of Histochemistry & Cytochemistry · doi:10.1177/12.3.219 · Cited by 3,367
Cell death during development of the nervous system
Oppenheim, R. W. (1991) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.14.030191.002321 · Cited by 3,084
Requirement for neuregulin receptor erbB2 in neural and cardiac development
Lee, K.-F., Simon, H., Chen, H., Bates, B., Hung, M.-C., & Hauser, C. (1995) · Nature · doi:10.1038/378394a0 · Cited by 1,290
Multiple essential functions of neuregulin in development
Meyer, D., & Birchmeier, C. (1995) · Nature · doi:10.1038/378386a0 · Cited by 1,262
Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor
Gassmann, M., Casagranda, F., Orioli, D., Simon, H., Lai, C., Klein, R., & Lemke, G. (1995) · Nature · doi:10.1038/378390a0 · Cited by 1,148
Identification of Heregulin, a Specific Activator of p185 erbB2
Holmes, W. E., Sliwkowski, M. X., Akita, R. W., Henzel, W. J., Lee, J., Park, J. W., Yansura, D., Abadi, N., Raab, H., Lewis, G. D., et al. (1992) · Science · doi:10.1126/science.256.5060.1205 · Cited by 962
Defective Neuromuscular Synaptogenesis in Agrin-Deficient Mutant Mice
Gautam, M., Noakes, P. G., Moscoso, L., Rupp, F., Scheller, R. H., Merlie, J. P., & Sanes, J. R. (1996) · Cell · doi:10.1016/s0092-8674(00)81253-2 · Cited by 934
Segmental patterns of neuronal development in the chick hindbrain
Lumsden, A., & Keynes, R. (1989) · Nature · doi:10.1038/337424a0 · Cited by 846
Synaptic structure and development: The neuromuscular junction
Hall, Z. W., & Sanes, J. R. (1993) · Cell · doi:10.1016/s0092-8674(05)80031-5 · Cited by 834
Sox10, a Novel Transcriptional Modulator in Glial Cells
Kuhlbrodt, K., Herbarth, B., Sock, E., Hermans-Borgmeyer, I., & Wegner, M. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-01-00237.1998 · Cited by 781
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Prenatal Infection and Schizophrenia: A Review of Epidemiologic and Translational Studies
Brown, A. S., & Derkits, E. J. (2010) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2009.09030361 · Cited by 1,269
Neuregulin 1 in neural development, synaptic plasticity and schizophrenia
Mei, L., & Xiong, W.-C. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2392 · Cited by 1,030
The transcription factor Sox10 is a key regulator of peripheral glial development
Britsch, S., Goerich, D. E., Riethmacher, D., Peirano, R. I., Rossner, M., Nave, K.-A., Birchmeier, C., & Wegner, M. (2001) · Genes & Development · doi:10.1101/gad.186601 · Cited by 914
The Neuregulin-1 Receptor ErbB4 Controls Glutamatergic Synapse Maturation and Plasticity
Li, B., Woo, R.-S., Mei, L., & Malinow, R. (2007) · Neuron · doi:10.1016/j.neuron.2007.03.028 · Cited by 354
Chen, Y.-J. J., Johnson, M. A., Lieberman, M. D., Goodchild, R. E., Schobel, S., Lewandowski, N., Rosoklija, G., Liu, R.-C., Gingrich, J. A., Small, S., et al. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.1815-08.2008 · Cited by 188
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Metadata
- Authors
- Wolpowitz, D., Mason, T. B. A., Dietrich, P., Mendelsohn, M., Talmage, D. A., & Role, L. W.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2000-01
- Volume
- 25
- Issue
- 1
- Pages
- 79-91
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2068488653
- Cited by
- 313
- References
- 61
- FWCI
- 6.50
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Wolpowitz, D., Mason, T. B. A., Dietrich, P., Mendelsohn, M., Talmage, D. A., & Role, L. W. (2000). Cysteine-Rich Domain Isoforms of the Neuregulin-1 Gene Are Required for Maintenance of Peripheral Synapses. Neuron. https://doi.org/10.1016/s0896-6273(00)80873-9
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