The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Defective Neuromuscular Synaptogenesis in Agrin-Deficient Mutant Mice
Open accessAbstract
During neuromuscular synapse formation, motor axons induce clustering of acetylcholine receptors (AChRs) in the muscle fiber membrane. The protein agrin, originally isolated from the basal lamina of the synaptic cleft, is synthesized and secreted by motoneurons and triggers formation of AChR clusters on cultured myotubes. We show here postsynaptic AChR aggregates are markedly reduced in number, size, and density in muscles of agrin-deficient mutant mice. These results support the hypothesis that agrin is a critical organizer of postsynaptic differentiation does occur in the mutant, suggesting the existence of a second-nerve-derived synaptic organizing signal. In addition, we show that intramuscular nerve branching and presynaptic differentiation are abnormal in the mutant, phenotypes which may reflect either a distinct effect of agrin or impaired retrograde signaling from a defective postsynaptic apparatus.
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Reist, N. E., Werle, M. J., & McMahan, U. J. (1992) · Neuron · doi:10.1016/0896-6273(92)90200-w · Cited by 237
Acetylcholine receptor-aggregating activity of agrin isoforms and mapping of the active site.
Gesemann, M., Denzer, A. J., & Ruegg, M. A. (1995) · The Journal of cell biology · doi:10.1083/jcb.128.4.625 · Cited by 236
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DEVELOPMENT OF THE VERTEBRATE NEUROMUSCULAR JUNCTION
Sanes, J. R., & Lichtman, J. W. (1999) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.22.1.389 · Cited by 1,532
Self-citationLRP4 serves as a coreceptor of Agrin
Zhang, B., Luo, S., Wang, Q., Suzuki, T., Xiong, W. C., & Mei, L. (2008) · Neuron · doi:10.1016/j.neuron.2008.10.006 · Cited by 525
Extracellular Matrix: Functions in the Nervous System
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Metadata
- Authors
- Gautam, M., Noakes, P. G., Moscoso, L., Rupp, F., Scheller, R. H., Merlie, J. P., & Sanes, J. R.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1996-05
- Volume
- 85
- Issue
- 4
- Pages
- 525-535
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2044199827
- Cited by
- 934
- References
- 2
- FWCI
- 20.53
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- The paper
- Gautam, M., Noakes, P. G., Moscoso, L., Rupp, F., Scheller, R. H., Merlie, J. P., & Sanes, J. R. (1996). Defective Neuromuscular Synaptogenesis in Agrin-Deficient Mutant Mice. Cell. https://doi.org/10.1016/s0092-8674(00)81253-2
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