Cited by 525Sleep and Wakefulness ResearchVisual perception and processing mechanismsNeurogenesis and neuroplasticity mechanisms

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Sleep Enhances Plasticity in the Developing Visual Cortex

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Frank, Marcos G, Issa, Naoum P, Stryker, Michael P·2001·Neuron

DOI 10.1016/s0896-6273(01)00279-3

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Abstract

During a critical period of brain development, occluding the vision of one eye causes a rapid remodeling of the visual cortex and its inputs. Sleep has been linked to other processes thought to depend on synaptic remodeling, but a role for sleep in this form of cortical plasticity has not been demonstrated. We found that sleep enhanced the effects of a preceding period of monocular deprivation on visual cortical responses, but wakefulness in complete darkness did not do so. The enhancement of plasticity by sleep was at least as great as that produced by an equal amount of additional deprivation. These findings demonstrate that sleep and sleep loss modify experience-dependent cortical plasticity in vivo. They suggest that sleep in early life may play a crucial role in brain development.

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Authors: Frank, M. G., Issa, N. P., & Stryker, M. P.
Affiliations: University of California, San Francisco (US)
Corresponding author: Stryker, Michael P
ORCID: Frank, Marcos G
Issa, Naoum P
Stryker, Michael P
Venue: Neuron
Publisher: Elsevier BV
Published: 2001-04
Volume: 30
Issue: 1
Pages: 275-287
ISSN: 0896-6273 (ISSN-L)
DOI: 10.1016/s0896-6273(01)00279-3
OpenAlex: W2171903257
Cited by: 523
References: 92
Citations by year: 2026: 8 · 2025: 33 · 2024: 14 · 2023: 33 · 2022: 20 · 2021: 15 · 2020: 20 · 2019: 36 · 2018: 15 · 2017: 21 · 2016: 13 · 2015: 10 · 2014: 15 · 2013: 19 · 2012: 22
FWCI: 15.37
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 4490 d)
Locations: Neuron (publishedVersion)
PubMed (publishedVersion)
Funders: National Eye Institute (F32EY006880, R01EY002874, EY-02874, R37EY002874, EY06880, EY60831)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords: sleep, visual cortex, monocular deprivation, cortical plasticity, critical period, experience-dependent plasticity, synaptic remodeling, sleep deprivation, brain development, ocular dominance
MeSH terms: Action Potentials, Animals, Blindness, Cats, Electroencephalography, Female, Male, Neuronal Plasticity, Neurons, Sleep, Sleep, REM, Visual Cortex, Visual Pathways, Wakefulness

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Sleep Enhances Plasticity in the Developing Visual Cortex

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