Cited by 1,173Memory and Neural MechanismsSleep and Wakefulness ResearchNeural dynamics and brain function

Replay of neuronal firing sequences in rat hippocampus during sleep following spatial experience

Skaggs, William E., McNaughton, Bruce L.·1996·Science

Abstract

The correlated activity of rat hippocampal pyramidal cells during sleep reflects the activity of those cells during earlier spatial exploration. Now the patterns of activity during sleep have also been found to reflect the order in which the cells fired during spatial exploration. This relation was reliably stronger for sleep after the behavioral session than before it; thus, the activity during sleep reflects changes produced by experience. This memory for temporal order of neuronal firing could be produced by an interaction between the temporal integration properties of long-term potentiation and the phase shifting of spike activity with respect to the hippocampal theta rhythm.

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Registry

Crossref · 10.1126/science.271.5257.1870

Cites

15 of 15 references verified0 citation errors · 0 not checkable

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  • Replay was originally discovered in the hippocampus of rats, but the original analysis was for slow wave sleep, not correlating this process to dreaming specifically.

    “Replay was originally discovered in the hippocampus of rats,62,63 although the original analysis was again for slow wave sleep, not correlating this process to dreaming specifically.”
  • Cells contributing to reactivations are not only coactivated, but a temporal order of spiking in the assembly is also preserved.

    “Importantly, further studies showed that cells contributing to reactivations are not only coactivated, but a temporal order of spiking in the assembly is also preserved (1089).”

    From About Sleep's Role in Memory (2013) · cites this paper as [1089]

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Authors
Skaggs, W. E., & McNaughton, B. L.
Affiliations
University of Arizona (US)
Venue
Science
Published
1996-03-29
Volume
271
Issue
5257
Pages
1870-1873
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2000775105
Cited by
1,173
References
15
Citations by year
2026: 38 · 2025: 52 · 2024: 77 · 2023: 54 · 2022: 45 · 2021: 52 · 2020: 58 · 2019: 73 · 2018: 58 · 2017: 49 · 2016: 41 · 2015: 37 · 2014: 62 · 2013: 40 · 2012: 36
FWCI
14.06
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute on Aging (AG-12609)
  • National Institute of Mental Health (MH 46823)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords
hippocampal replay, sleep, spatial exploration, hippocampal pyramidal neurons, temporal order memory, long-term potentiation, theta oscillations, spatial memory
MeSH terms
Action Potentials, Animals, Male, Memory, Motor Activity, Rats, Inbred F344, Sleep, Theta Rhythm, Time Factors, Long-Term Potentiation, Pyramidal Cells, Rats

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