The DOI matches its Crossref record; 64 of the 64 references it cites were found in a registry or an index.
Regulation of Synaptic Strength by Protein Phosphatase 1
Open accessAbstract
We investigated the role of postsynaptic protein phosphatase 1 (PP1) in regulating synaptic strength by loading CA1 pyramidal cells either with peptides that disrupt PP1 binding to synaptic targeting proteins or with active PP1. The peptides blocked synaptically evoked LTD but had no effect on basal synaptic currents mediated by either AMPA or NMDA receptors. They did, however, cause an increase in synaptic strength following the induction of LTD. Similarly, PP1 had no effect on basal synaptic strength but enhanced LTD. In cultured neurons, synaptic activation of NMDA receptors increased the proportion of PP1 localized to synapses. These results suggest that PP1 does not significantly regulate basal synaptic strength. Appropriate NMDA receptor activation, however, allows PP1 to gain access to synaptic substrates and be recruited to synapses where its activity is necessary for sustaining LTD.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“In a series of classic studies it was found that LTD is induced by the activation of a high-affinity Ca2+ cascade resulting in the activation of PP1 (395–397).”
From Synaptic memory and CaMKII (2023) · cites this paper as [396]
Experimental — accuracy not yet measuredThe check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“A previous study has reported that PP1 is recruited to synapses in response to NMDAR activation [50].”
From Regulated RalBP1 Binding to RalA and PSD-95 Controls AMPA Receptor Endocytosis and LTD (2009) · cites this paper as [50]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Long-Term Potentiation--A Decade of Progress?
Malenka, R. C., & Nicoll, A. R. A. (1999) · Science · doi:10.1126/science.285.5435.1870 · Cited by 2,729
Self-citationMetaplasticity: the plasticity of synaptic plasticity
Abraham, W. C., & Bear, M. F. (1996) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)80018-x · Cited by 1,833
Sensitivity of CaM Kinase II to the Frequency of Ca 2+ Oscillations
De Koninck, P., & Schulman, H. (1998) · Science · doi:10.1126/science.279.5348.227 · Cited by 1,269
Evidence for silent synapses: Implications for the expression of LTP
Isaac, J. T. R., Nicoll, R. A., & Malenka, R. C. (1995) · Neuron · doi:10.1016/0896-6273(95)90046-2 · Cited by 1,233
Self-citationA mechanism for the Hebb and the anti-Hebb processes underlying learning and memory.
Lisman, J. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.23.9574 · Cited by 1,127
Regulation of distinct AMPA receptor phosphorylation sites during bidirectional synaptic plasticity
Lee, H.-K., Barbarosie, M., Kameyama, K., Bear, M. F., & Huganir, R. L. (2000) · Nature · doi:10.1038/35016089 · Cited by 1,116
Reinsertion or Degradation of AMPA Receptors Determined by Activity-Dependent Endocytic Sorting
Ehlers, M. D. (2000) · Neuron · doi:10.1016/s0896-6273(00)00129-x · Cited by 1,096
Involvement of a calcineurin/ inhibitor-1 phosphatase cascade in hippocampal long-term depression
Mulkey, R. M., Endo, S., Shenolikar, S., & Malenka, R. C. (1994) · Nature · doi:10.1038/369486a0 · Cited by 1,083
Self-citationRole for rapid dendritic protein synthesis in hippocampal mGluR-dependent long-term depression.
Huber, K., Kayser, M., & Bear, M. (2000) · Science · doi:10.1126/science.288.5469.1254 · Cited by 1,015
NMDA-receptor-dependent synaptic plasticity: multiple forms and mechanisms
Malenka, R. C., & Nicoll, R. A. (1993) · Trends in Neurosciences · doi:10.1016/0166-2236(93)90197-t · Cited by 904
Self-citation
Cited by
Sorted by citations
Items 201–229 of 229
Bell, M. K., & Rangamani, P. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.12.23.473965 · Cited by 2
PP1β opposes classic PP1 function, inhibiting spine maturation and promoting LTPPreprint
Foley, K., McKee, C., Mayer, A., Ganguly, A., Barnett, D., Ward, N., Zhang, Y., Nairn, A. C., & Xia, H. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.01.26.525737 · Cited by 2
Self-citationTargeting neuroplasticity in old brain: restoring synapse with cognitive strategies
Kopalli, S. R., Kale, M. B., Yadav, A., Alshahrani, S., Mohammed, A., Oirdi, M. E., Farhan, M., Taksande, B. G., Upaganlawar, A. B., Umekar, M. J., et al. (2026) · Biogerontology · doi:10.1007/s10522-026-10408-1 · Cited by 2
The Kv2.1 channels mediate neuronal apoptosis induced by excitotoxicity
Yao, H., Zhou, K., Yan, D., Li, M., & Wang, Y. (2009) · Journal of Neurochemistry · doi:10.1111/j.0022-3042.2008.05834.x · Cited by 1
Zhang, G., Lin, L., Yang, H., Wang, T., Li, X., Li, G., Wen, S., & Wang, D. (2011) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2011.08.061 · Cited by 1
Protein Phosphatase 1 as a Potential Mediator of Aluminum Neurotoxicity
Silva, E. F. D. C. E., & O'Callaghan, J. P. (2010) · Elsevier eBooks · doi:10.1016/b978-0-08-046884-6.01311-7 · Cited by 1
NMDAR-activated PP1 dephosphorylates GluN2B to modulate NMDAR synaptic contentPreprint
Chiu, A. M., Wang, J., Fiske, M. P., Hubalkova, P., Barse, L., Gray, J. A., & Sanz-Clemente, A. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/520882 · Cited by 1
Protein phosphatase 1 is a molecular constraint on learning and memory
Squyars, C., Miller, A. D., Blake, P., Zwerner, D., Westcott, E., Foster, V., Ott, L. W., Walker, E. A., & Watts, J. D. (2002)
Tadavarty, R. (2012) · cIRcle (University of British Columbia) · doi:10.14288/1.0072600
Ruggiero, R. N., Bueno-Júnior, L. S., Ross, J. B. D., Fachim, H., Padovan‐Neto, F. E., Merlo, S., Rohner, C. J. S., Ikeda, E. T., Brusco, J., & Moreira, J. E. (2011)
Dopamine Receptors and their Interactions with NMDA Receptors
Gibb, A. J., & Tong, H. (2011) · Frontiers in neuroscience · doi:10.1201/b11284-4
Dendritic Protein Phosphatase Complexes
Baucum, A. J., & Colbran, R. J. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-374145-5.00167-4
Dendritic Protein Phosphatase Complexes
Colbran, R. J. (2003) · Elsevier eBooks · doi:10.1016/b978-012124546-7/50549-0
Cognitive function in mice with segmental trisomy of human chromosome 21 Down Syndrome genes
Canonica, T. (2019) · ORCA Online Research @Cardiff (Cardiff University)
Post-Translational Protein Modifications involved in Exo- and Endocytosis of Synaptic Vesicles
Silbern, I. (2021) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-8895
Turrigiano, G. G. (2006) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.1050471.503296
Graziane, N., & Dong, Y. (2022) · Neuromethods · doi:10.1007/978-1-0716-2589-7_12
Mäki‐Marttunen, T., Blackwell, K. T., Akkouh, I. A., Shadrin, A. A., Valstad, M., Elvsåashagen, T., Linne, M., Djurovic, S., Einevoll, G. T., & Andreassen, O. A. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.06.14.544920
Protein Phosphatase 1 as a Potential Mediator of Metal Neurotoxicity
Silva, O. A. B. D. C. E. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.65383-7
NMDAR-Activated PP1 Dephosphorylates GluN2B to Modulate NMDAR-PlasticityPreprint
Chiu, A. M., Wang, J., Fiske, M. P., Hubálková, P., Barse, L. W., Gray, J. A., & Sanz-Clemente, A. (2019) · SSRN Electronic Journal · doi:10.2139/ssrn.3330559
Carponcy, J. (2016) · theses.fr (ABES) · doi:10.70675/73b8e92fzcf31z47b3z9f72z5646ff84d048
Altérations de la connectivité corticale au cours de périodes critiques du développement
Druart, M. (2020) · theses.fr (ABES) · doi:10.70675/b4f48d73za850z42b2z8dadzfad47d4f0a69
Metadata
- Authors
- Morishita, W., Connor, J. H., Xia, H., Quinlan, E. M., Shenolikar, S., & Malenka, R. C.
- Affiliations
- Stanford Medicine (US)
- Duke Medical Center (US)
- University of Maryland, College Park (US)
- Corresponding author
- Malenka, Robert C
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2001-12
- Volume
- 32
- Issue
- 6
- Pages
- 1133-1148
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W1985405412
- Cited by
- 227
- References
- 64
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 6 · 2023: 4 · 2022: 3 · 2021: 6 · 2020: 9 · 2019: 8 · 2018: 10 · 2017: 4 · 2016: 8 · 2015: 8 · 2014: 7 · 2013: 8 · 2012: 10
- FWCI
- 5.59
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (MH00942)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK-52054, R01DK052054)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- protein phosphatase 1, synaptic efficacy, long-term depression, NMDA receptor activation, AMPA receptors, postsynaptic proteins, CA1 pyramidal neurons, synaptic plasticity
- MeSH terms
- Neurabins, Animals, Cells, Cultured, Hippocampus, Microfilament Proteins, Nerve Tissue Proteins, Neural Inhibition, Synaptic Transmission, Peptide Fragments, Phosphoprotein Phosphatases, Synapses, Receptors, N-Methyl-D-Aspartate, Rats, Sprague-Dawley, Long-Term Potentiation, Pyramidal Cells, Receptors, AMPA, Receptors, Metabotropic Glutamate, Excitatory Postsynaptic Potentials, Rats, Protein Phosphatase 1
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
