The DOI matches its Crossref record; 64 of the 64 references it cites were found in a registry or an index.
Regulation of Synaptic Strength by Protein Phosphatase 1
Open accessAbstract
We investigated the role of postsynaptic protein phosphatase 1 (PP1) in regulating synaptic strength by loading CA1 pyramidal cells either with peptides that disrupt PP1 binding to synaptic targeting proteins or with active PP1. The peptides blocked synaptically evoked LTD but had no effect on basal synaptic currents mediated by either AMPA or NMDA receptors. They did, however, cause an increase in synaptic strength following the induction of LTD. Similarly, PP1 had no effect on basal synaptic strength but enhanced LTD. In cultured neurons, synaptic activation of NMDA receptors increased the proportion of PP1 localized to synapses. These results suggest that PP1 does not significantly regulate basal synaptic strength. Appropriate NMDA receptor activation, however, allows PP1 to gain access to synaptic substrates and be recruited to synapses where its activity is necessary for sustaining LTD.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“In a series of classic studies it was found that LTD is induced by the activation of a high-affinity Ca2+ cascade resulting in the activation of PP1 (395–397).”
From Synaptic memory and CaMKII (2023) · cites this paper as [396]
Experimental — accuracy not yet measuredThe check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“A previous study has reported that PP1 is recruited to synapses in response to NMDAR activation [50].”
From Regulated RalBP1 Binding to RalA and PSD-95 Controls AMPA Receptor Endocytosis and LTD (2009) · cites this paper as [50]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Long-Term Potentiation--A Decade of Progress?
Malenka, R. C., & Nicoll, A. R. A. (1999) · Science · doi:10.1126/science.285.5435.1870 · Cited by 2,729
Self-citationMetaplasticity: the plasticity of synaptic plasticity
Abraham, W. C., & Bear, M. F. (1996) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)80018-x · Cited by 1,833
Sensitivity of CaM Kinase II to the Frequency of Ca 2+ Oscillations
De Koninck, P., & Schulman, H. (1998) · Science · doi:10.1126/science.279.5348.227 · Cited by 1,269
Evidence for silent synapses: Implications for the expression of LTP
Isaac, J. T. R., Nicoll, R. A., & Malenka, R. C. (1995) · Neuron · doi:10.1016/0896-6273(95)90046-2 · Cited by 1,233
Self-citationA mechanism for the Hebb and the anti-Hebb processes underlying learning and memory.
Lisman, J. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.23.9574 · Cited by 1,127
Regulation of distinct AMPA receptor phosphorylation sites during bidirectional synaptic plasticity
Lee, H.-K., Barbarosie, M., Kameyama, K., Bear, M. F., & Huganir, R. L. (2000) · Nature · doi:10.1038/35016089 · Cited by 1,116
Reinsertion or Degradation of AMPA Receptors Determined by Activity-Dependent Endocytic Sorting
Ehlers, M. D. (2000) · Neuron · doi:10.1016/s0896-6273(00)00129-x · Cited by 1,096
Involvement of a calcineurin/ inhibitor-1 phosphatase cascade in hippocampal long-term depression
Mulkey, R. M., Endo, S., Shenolikar, S., & Malenka, R. C. (1994) · Nature · doi:10.1038/369486a0 · Cited by 1,083
Self-citationRole for rapid dendritic protein synthesis in hippocampal mGluR-dependent long-term depression.
Huber, K., Kayser, M., & Bear, M. (2000) · Science · doi:10.1126/science.288.5469.1254 · Cited by 1,015
NMDA-receptor-dependent synaptic plasticity: multiple forms and mechanisms
Malenka, R. C., & Nicoll, R. A. (1993) · Trends in Neurosciences · doi:10.1016/0166-2236(93)90197-t · Cited by 904
Self-citationOn target with a new mechanism for the regulation of protein phosphorylation
Hubbard, M. J., & Cohen, P. (1993) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(93)90109-z · Cited by 896
Derkach, V., Barria, A., & Soderling, T. R. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.6.3269 · Cited by 842
Regulation of AMPA receptor endocytosis by a signaling mechanism shared with LTD
Beattie, E. C., Carroll, R. C., Yu, X., Morishita, W., Yasuda, H., von Zastrow, M., & Malenka, R. C. (2000) · Nature Neuroscience · doi:10.1038/81823 · Cited by 745
Self-citationInteraction with the NMDA receptor locks CaMKII in an active conformation
Bayer, K.-U., De Koninck, P., Leonard, A. S., Hell, J. W., & Schulman, H. (2001) · Nature · doi:10.1038/35081080 · Cited by 732
Man, H., Lin, J., Ju, W. H., Ahmadian, G., Liu, L., Becker, L. E., Sheng, M., & Wang, Y. T. (2000) · Neuron · doi:10.1016/s0896-6273(00)81067-3 · Cited by 711
An Essential Role for Protein Phosphatases in Hippocampal Long-Term Depression
Mulkey, R. M., Herron, C. E., & Malenka, R. C. (1993) · Science · doi:10.1126/science.8394601 · Cited by 699
Self-citationRole of AMPA Receptor Cycling in Synaptic Transmission and Plasticity
Lüscher, C., Xia, H., Beattie, E. C., Carroll, R. C., von Zastrow, M., Malenka, R. C., & Nicoll, R. A. (1999) · Neuron · doi:10.1016/s0896-6273(00)81119-8 · Cited by 692
Self-citationShen, K., & Meyer, T. (1999) · Science · doi:10.1126/science.284.5411.162 · Cited by 673
Lee, H.-K., Kameyama, K., Huganir, R. L., & Bear, M. F. (1998) · Neuron · doi:10.1016/s0896-6273(00)80632-7 · Cited by 668
Control of GluR1 AMPA receptor function by cAMP-dependent protein kinase
Banke, T. G., Bowie, D., Lee, H.-K., Huganir, R. L., Schousboe, A., & Traynelis, S. F. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-01-00089.2000 · Cited by 652
Egloff, M. P., Johnson, D. F., Moorhead, G., Cohen, P. T. W., Cohen, P., & Barford, D. (1997) · The EMBO Journal · doi:10.1093/emboj/16.8.1876 · Cited by 626
Two Distinct Forms of Long-Term Depression Coexist in CA1 Hippocampal Pyramidal Cells
Oliet, S. H. R., Malenka, R. C., & Nicoll, R. A. (1997) · Neuron · doi:10.1016/s0896-6273(00)80336-0 · Cited by 578
Self-citationPostsynaptic protein phosphorylation and LTP
Soderling, T. R., & Derkach, V. A. (2000) · Trends in Neurosciences · doi:10.1016/s0166-2236(99)01490-3 · Cited by 559
Chung, H. J., Xia, J., Scannevin, R. H., Zhang, X., & Huganir, R. L. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-19-07258.2000 · Cited by 558
Modulation of AMPA receptor unitary conductance by synaptic activity
Benke, T. A., Lüthi, A., Isaac, J. T. R., & Collingridge, G. L. (1998) · Nature · doi:10.1038/31709 · Cited by 533
Regulation of NMDA Receptors by an Associated Phosphatase-Kinase Signaling Complex
Westphal, R. S., Tavalin, S. J., Lin, J., Alto, N. M., Fraser, I. D. C., Langeberg, L. K., Sheng, M., & Scott, J. D. (1999) · Science · doi:10.1126/science.285.5424.93 · Cited by 495
Carroll, R. C., Lissin, D., von Zastrow, M., Nicoll, R. A., & Malenka, R. C. (1999) · Nature Neuroscience · doi:10.1038/8123 · Cited by 472
Self-citationTargeting of PKA to Glutamate Receptors through a MAGUK-AKAP Complex
Colledge, M., Dean, R. A., Scott, G. K., Langeberg, L. K., Huganir, R. L., & Scott, J. D. (2000) · Neuron · doi:10.1016/s0896-6273(00)00013-1 · Cited by 467
Strack, S., & Colbran, R. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.33.20689 · Cited by 466
Role of ampa receptor endocytosis in synaptic plasticity
Carroll, R. C., Beattie, E. C., von Zastrow, M., & Malenka, R. C. (2001) · Nature Reviews Neuroscience · doi:10.1038/35072500 · Cited by 448
Self-citationSpinophilin, a novel protein phosphatase 1 binding protein localized to dendritic spines
Allen, P. B., Ouimet, C. C., & Greengard, P. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.18.9956 · Cited by 440
Leonard, A. S., Lim, I. A., Hemsworth, D. E., Horne, M. C., & Hell, J. W. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.6.3239 · Cited by 385
Spinophilin regulates the formation and function of dendritic spines
Feng, J., Yan, Z., Ferreira, A., Tomizawa, K., Liauw, J. A., Zhuo, M., Allen, P. B., Ouimet, C. C., & Greengard, P. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.16.9287 · Cited by 374
Kim, C., Chung, H. J., Lee, H., & Huganir, R. L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.211132798 · Cited by 364
Palmer, M. J., Irving, A. J., Seabrook, G. R., Jane, D. E., & Collingridge, G. L. (1997) · Neuropharmacology · doi:10.1016/s0028-3908(97)00181-0 · Cited by 345
Can molecules explain long-term potentiation?
Sanes, J. R., & Lichtman, J. W. (1999) · Nature Neuroscience · doi:10.1038/10154 · Cited by 336
Daw, M. I., Chittajallu, R., Bortolotto, Z. A., Dev, K. K., Duprat, F., Henley, J. M., Collingridge, G. L., & Isaac, J. T. R. (2000) · Neuron · doi:10.1016/s0896-6273(00)00160-4 · Cited by 323
O’Dell, T. J., & Kandel, E. R. (1994) · Learning & Memory · doi:10.1101/lm.1.2.129 · Cited by 303
Hippocampal LTD Expression Involves a Pool of AMPARs Regulated by the NSF–GluR2 Interaction
Lüthi, A., Chittajallu, R., Duprat, F., Palmer, M. J., Benke, T. A., Kidd, F. L., Henley, J. M., Isaac, J. T. R., & Collingridge, G. L. (1999) · Neuron · doi:10.1016/s0896-6273(00)80852-1 · Cited by 298
Combinatorial control of protein phosphatase-1
Bollen, M. (2001) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(01)01836-9 · Cited by 294
Yan, Z., Hsieh‐Wilson, L. C., Feng, J., Tomizawa, K., Allen, P. B., Fienberg, A. A., Nairn, A. C., & Greengard, P. (1999) · Nature Neuroscience · doi:10.1038/4516 · Cited by 291
Kameyama, K., Lee, H.-K., Bear, M. F., & Huganir, R. L. (1998) · Neuron · doi:10.1016/s0896-6273(00)80633-9 · Cited by 283
Matsuda, S., Mikawa, S., & Hirai, H. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.731765.x · Cited by 263
Sculptoreanu, A., Scheuer, T., & Catterall, W. A. (1993) · Nature · doi:10.1038/364240a0 · Cited by 263
Dual MAP kinase pathways mediate opposing forms of long-term plasticity at CA3–CA1 synapses
Bolshakov, V. Y., Carboni, L., Cobb, M. H., Siegelbaum, S. A., & Belardetti, F. (2000) · Nature Neuroscience · doi:10.1038/80624 · Cited by 217
Molecular memory by reversible translocation of calcium/calmodulin-dependent protein kinase II
Shen, K., Teruel, M. N., Connor, J. H., Shenolikar, S., & Meyer, T. (2000) · Nature Neuroscience · doi:10.1038/78783 · Cited by 206
Self-citationPhysiologic importance of protein phosphatase inhibitors
Shenolikar, S. (1998) · Frontiers in bioscience · doi:10.2741/a336 · Cited by 194
Self-citationJohnson, B. D., Scheuer, T., & Catterall, W. A. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.24.11492 · Cited by 187
Endo, S., Zhou, X., Connor, J. H., Wang, B., & Shenolikar, S. (1996) · Biochemistry · doi:10.1021/bi952940f · Cited by 155
Self-citationThe Calcineurin-Dynamin 1 Complex as a Calcium Sensor for Synaptic Vesicle Endocytosis
Lai, M. M.-S., Hong, J. J., Ruggiero, A. M., Burnett, P. E., Slepnev, V. I., Camilli, P. V. D., & Snyder, S. H. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.37.25963 · Cited by 145
Independent mechanisms for long-term depression of AMPA and NMDA responses.
Selig, D. K., Hjelmstad, G., Herron, C., Nicoll, R., & Malenka, R. (1995) · Neuron · doi:10.1016/0896-6273(95)90045-4 · Cited by 137
Self-citationHsieh‐Wilson, L. C., Allen, P. B., Watanabe, T., Nairn, A. C., & Greengard, P. (1999) · Biochemistry · doi:10.1021/bi982900m · Cited by 118
Brain protein serine/threonine phosphatases
Price, N. E., & Mumby, M. C. (1999) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(99)80049-x · Cited by 109
Fraser, I. D. C., & Scott, J. D. (1999) · Neuron · doi:10.1016/s0896-6273(00)80795-3 · Cited by 106
MacMillan, L. B., Bass, M. A., Cheng, N., Howard, E. F., Tamura, M., Strack, S., Wadzinski, B. E., & Colbran, R. J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.50.35845 · Cited by 105
Regulation of Neurabin I Interaction with Protein Phosphatase 1 by Phosphorylation
McAvoy, T., Allen, P. B., Obaishi, H., Nakanishi, H., Takai, Y., Greengard, P., Nairn, A. C., & Hemmings, H. C. (1999) · Biochemistry · doi:10.1021/bi991227d · Cited by 89
Thiels, E., Norman, E. D., Barrionuevo, G., & Klann, E. (1998) · Neuroscience · doi:10.1016/s0306-4522(98)00135-3 · Cited by 72
[34] Preparation of low-molecular -weight forms of rabbit muscle protein phosphatase
DeGuzman, A., & Lee, E. Y. C. (1988) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(88)59036-5 · Cited by 69
Beullens, M., Vulsteke, V., Eynde, A. V., Jagiełło, I., Stalmans, W., & Bollen, M. (2000) · Biochemical Journal · doi:10.1042/0264-6021:3520651 · Cited by 64
Terry-Lorenzo, R. T., Inoue, M., Connor, J. H., Haystead, T., Armbruster, B. N., Gupta, R. P., Oliver, C. J., & Shenolikar, S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.4.2439 · Cited by 62
Self-citationMoorhead, G. B. G., Johnson, D., Morrice, N., & Cohen, P. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)01276-9 · Cited by 60
Cellular Mechanisms Regulating Protein Phosphatase-1
Connor, J. H., Frederick, D., Huang, H., Yang, J., Helps, N. R., Cohen, P. T. W., Nairn, A. C., DePaoli-Roach, A. A., Tatchell, K., & Shenolikar, S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m909312199 · Cited by 56
Self-citationLiu, J., & Brautigan, D. L. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m003843200 · Cited by 53
Liu, J., Wu, J., Oliver, C. J., Shenolikar, S., & Brautigan, D. L. (2000) · Biochemical Journal · doi:10.1042/bj3460077 · Cited by 27
Self-citation
Cited by
Sorted by citations
Malenka, R. C., & Bear, M. F. (2004) · Neuron · doi:10.1016/j.neuron.2004.09.012 · Cited by 3,968
Self-citationSynaptic Plasticity: Multiple Forms, Functions, and Mechanisms
Citri, A., & Malenka, R. C. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301559 · Cited by 2,323
Self-citationShrinkage of dendritic spines associated with long-term depression of hippocampal synapses
Zhou, Q., Homma, K. J., & Poo, M.-M. (2004) · Neuron · doi:10.1016/j.neuron.2004.11.011 · Cited by 1,025
Long-term depression in the CNS
Collingridge, G. L., Peineau, S., Howland, J. G., & Wang, Y. T. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2867 · Cited by 926
DARPP-32: An Integrator of Neurotransmission
Svenningsson, P., Nishi, A., Fisone, G., Girault, J., Nairn, A. C., & Greengard, P. (2004) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.44.101802.121415 · Cited by 737
Metadata
- Authors
- Morishita, W., Connor, J. H., Xia, H., Quinlan, E. M., Shenolikar, S., & Malenka, R. C.
- Affiliations
- Stanford Medicine (US)
- Duke Medical Center (US)
- University of Maryland, College Park (US)
- Corresponding author
- Malenka, Robert C
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2001-12
- Volume
- 32
- Issue
- 6
- Pages
- 1133-1148
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W1985405412
- Cited by
- 227
- References
- 64
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 6 · 2023: 4 · 2022: 3 · 2021: 6 · 2020: 9 · 2019: 8 · 2018: 10 · 2017: 4 · 2016: 8 · 2015: 8 · 2014: 7 · 2013: 8 · 2012: 10
- FWCI
- 5.59
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (MH00942)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK-52054, R01DK052054)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- protein phosphatase 1, synaptic efficacy, long-term depression, NMDA receptor activation, AMPA receptors, postsynaptic proteins, CA1 pyramidal neurons, synaptic plasticity
- MeSH terms
- Neurabins, Animals, Cells, Cultured, Hippocampus, Microfilament Proteins, Nerve Tissue Proteins, Neural Inhibition, Synaptic Transmission, Peptide Fragments, Phosphoprotein Phosphatases, Synapses, Receptors, N-Methyl-D-Aspartate, Rats, Sprague-Dawley, Long-Term Potentiation, Pyramidal Cells, Receptors, AMPA, Receptors, Metabotropic Glutamate, Excitatory Postsynaptic Potentials, Rats, Protein Phosphatase 1
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
