Regulation of distinct AMPA receptor phosphorylation sites during bidirectional synaptic plasticity

Lee, Hey-Kyoung; Barbarosie, Michaela; Kameyama, Kimihiko; Bear, Mark F.; Huganir, Richard L.

doi:10.1038/35016089

Regulation of distinct AMPA receptor phosphorylation sites during bidirectional synaptic plasticity

Bidirectional changes in the efficacy of neuronal synaptic transmission, such as hippocampal long-term potentiation (LTP) and long-term depression (LTD), are thought to be mechanisms for information storage in the brain. LTP and LTD may be mediated by the modulation of AMPA (alpha-amino-3-hydroxy…