The DOI matches its Crossref record; 79 of the 79 references it cites were found in a registry or an index.
Retinal Ganglion Cells Do Not Extend Axons by Default
Open accessAbstract
We investigate the signaling mechanisms that induce retinal ganglion cell (RGC) axon elongation by asking whether surviving neurons extend axons by default. We show that bcl-2 overexpression is sufficient to keep purified RGCs alive in the absence of any glial or trophic support. The bcl-2-expressing RGCs do not extend axons or dendrites unless signaled to do so by single peptide trophic factors. Axon growth stimulated by peptide trophic factors is remarkably slow but is profoundly potentiated by physiological levels of electrical activity spontaneously generated within embryonic explants or mimicked on a multielectrode silicon chip. These findings demonstrate that these surviving neurons do not constitutively extend axons and provide insight into the signals that may be necessary to promote CNS regeneration.
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Cites
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Cited by
Astrocyte scar formation aids central nervous system axon regeneration
Anderson, M. A., Burda, J. E., Ren, Y., Ao, Y., O’Shea, T. M., Kawaguchi, R., Coppola, G., Khakh, B. S., Deming, T. J., & Sofroniew, M. V. (2016) · Nature · doi:10.1038/nature17623 · Cited by 1,851
Promoting Axon Regeneration in the Adult CNS by Modulation of the PTEN/mTOR Pathway
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Amacrine-Signaled Loss of Intrinsic Axon Growth Ability by Retinal Ganglion Cells
Goldberg, J. L., Klassen, M. P., Hua, Y., & Barres, B. A. (2002) · Science · doi:10.1126/science.1068428 · Cited by 488
Self-citationNeuronal Intrinsic Mechanisms of Axon Regeneration
Liu, K., Tedeschi, A., Park, K. K., & He, Z. (2011) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-061010-113723 · Cited by 458
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Metadata
- Authors
- Goldberg, J. L., Espinosa, J. S., Xu, Y., Davidson, N., Kovacs, G. T. A., & Barres, B. A.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2002-02
- Volume
- 33
- Issue
- 5
- Pages
- 689-702
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2021814062
- Cited by
- 451
- References
- 79
- FWCI
- 7.51
- Type
- journal article
- Language
- en
- Open access
- bronze
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