Cited by 155Neuroscience and Neuropharmacology ResearchCellular transport and secretionExtracellular vesicles in disease

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Ectopic Release of Synaptic Vesicles

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Matsui, Ko, Jahr, Craig E·2003·Neuron

DOI 10.1016/s0896-6273(03)00788-8

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Abstract

Exocytosis of synaptic vesicles is generally assumed to occur only at ultrastructurally defined presynaptic active zones. If release is restricted to these sites, receptors not located within the synaptic cleft must be activated by transmitter that diffuses out of the cleft or not be activated at all. Here we report that AMPA receptor-mediated quantal events resulting from climbing fiber release are observed in Bergmann glial cells in the cerebellar cortex. These quantal events are not coincident with quanta recorded in neighboring Purkinje cells which receive input from the same climbing fiber. As Bergmann glial membranes are excluded from the synaptic cleft, we propose that exocytosis can occur from climbing fiber release sites located directly across from Bergmann glial membranes. Such ectopic release may account for the majority of the Bergmann glial AMPA response evoked by climbing fiber stimulation.

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Authors: Matsui, K., & Jahr, C. E.
Affiliations: Oregon Health & Science University (US)
Corresponding author: Jahr, Craig E
ORCID: Matsui, Ko
Venue: Neuron
Publisher: Elsevier BV
Published: 2003-12
Volume: 40
Issue: 6
Pages: 1173-1183
ISSN: 0896-6273 (ISSN-L)
DOI: 10.1016/s0896-6273(03)00788-8
OpenAlex: W2031373742
Cited by: 155
References: 50
Citations by year: 2026: 1 · 2025: 4 · 2024: 12 · 2023: 7 · 2022: 2 · 2021: 5 · 2020: 2 · 2019: 5 · 2018: 3 · 2017: 2 · 2016: 2 · 2015: 13 · 2014: 4 · 2013: 5 · 2012: 5
FWCI: 4.50
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 3516 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Neuron (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (NS40056)
Human Frontier Science Program (RG119/2000)
Japan Society for the Promotion of Science
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
Keywords: exocytosis, AMPA receptors, climbing fibers, Bergmann glia, cerebellar cortex, quantal release, Purkinje cells, synaptic cleft, active zone
MeSH terms: Animals, Animals, Newborn, Benzothiadiazines, Cerebellum, Exocytosis, Synaptic Vesicles, Receptors, AMPA, Glutamic Acid, Rats, In Vitro Techniques

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Ectopic Release of Synaptic Vesicles

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