Cited by 757Neuroinflammation and Neurodegeneration MechanismsPhagocytosis and Immune RegulationCell death mechanisms and regulation

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Microglia Promote the Death of Developing Purkinje Cells

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Marı́n-Teva, José Luis, Dusart, Isabelle, Colin, Catherine, Gervais, Annie, van Rooijen, Nico, Mallat, Michel·2004·Neuron

DOI 10.1016/s0896-6273(04)00069-8

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Abstract

The loss of neuronal cells, a prominent event in the development of the nervous system, involves regulated triggering of programmed cell death, followed by efficient removal of cell corpses. Professional phagocytes, such as microglia, contribute to the elimination of dead cells. Here we provide evidence that, in addition to their phagocytic activity, microglia promote the death of developing neurons engaged in synaptogenesis. In the developing mouse cerebellum, Purkinje cells die, and 60% of these neurons that already expressed activated caspase-3 were engulfed or contacted by spreading processes emitted by microglial cells. Apoptosis of Purkinje cells in cerebellar slices was strongly reduced by selective elimination of microglia. Superoxide ions produced by microglial respiratory bursts played a major role in this Purkinje cell death. Our study illustrates a mammalian form of engulfment-promoted cell death that links the execution of neuron death to the scavenging of dead cells.

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Kano, M., & Watanabe, T. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.733654736.793562673
The Role of Microglia in Neuroinflammation
Hung, S., Chen, C., Chen, H., Hung, Y.-C., Huang, P.-M., & Lin, C.-Y. (2022) · IntechOpen eBooks · doi:10.5772/intechopen.105865
Interrelation Between the Immune and the Nervous Systems in the Context of Cerebellar Development and Developmental Disorders
Eissa, N., Kermarrec, L., Tshikudi, D. M., Hesampour, F., & Ghia, J. (2023) · Contemporary clinical neuroscience · doi:10.1007/978-3-031-23104-9_16
Ablation of cell-specific cholesterol synthesis affects cerebral β-amyloidosis
Spieth, L. (2023) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-9780

Authors: Marı́n-Teva, J. L., Dusart, I., Colin, C., Gervais, A., van Rooijen, N., & Mallat, M.
Affiliations: Inserm (FR)
Vrije Universiteit Amsterdam (NL)
Corresponding author: Mallat, Michel
ORCID: Dusart, Isabelle
van Rooijen, Nico
Mallat, Michel
Venue: Neuron
Publisher: Elsevier BV
Published: 2004-02
Volume: 41
Issue: 4
Pages: 535-547
ISSN: 0896-6273 (ISSN-L)
DOI: 10.1016/s0896-6273(04)00069-8
OpenAlex: W2103711259
Cited by: 757
References: 82
Citations by year: 2026: 13 · 2025: 38 · 2024: 35 · 2023: 45 · 2022: 45 · 2021: 50 · 2020: 30 · 2019: 47 · 2018: 39 · 2017: 29 · 2016: 42 · 2015: 38 · 2014: 42 · 2013: 40 · 2012: 40
FWCI: 17.29
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 3454 d)
Locations: Neuron (publishedVersion)
PubMed (publishedVersion)
Pure Amsterdam UMC (publishedVersion)
Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion, other-oa)
HAL (submittedVersion)
Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam) (submittedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
Topics: Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Keywords: microglia, Purkinje cells, neuronal apoptosis, cerebellar development, phagocytosis, caspase-3, superoxide, synaptogenesis, neuronal cell death
MeSH terms: Animals, Antibodies, Cell Communication, Cell Differentiation, Cell Survival, Cerebellar Cortex, Enzyme Inhibitors, Mice, Inbred C57BL, Purkinje Cells, Signal Transduction, Free Radical Scavengers, Apoptosis, Microglia, Presynaptic Terminals, Receptors, Tumor Necrosis Factor, Mice, Knockout, Cell Respiration, Caspases, Mice, Caspase 3, In Vitro Techniques

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Microglia Promote the Death of Developing Purkinje Cells

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