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Cited by 757Neuroinflammation and Neurodegeneration MechanismsPhagocytosis and Immune RegulationCell death mechanisms and regulation

The DOI matches its Crossref record; 80 of the 82 references it cites were found in a registry or an index.

Microglia Promote the Death of Developing Purkinje Cells

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Marı́n-Teva, José Luis, Dusart, Isabelle, Colin, Catherine, Gervais, Annie, van Rooijen, Nico, Mallat, Michel·2004·Neuron
DOI 10.1016/s0896-6273(04)00069-8
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Abstract

The loss of neuronal cells, a prominent event in the development of the nervous system, involves regulated triggering of programmed cell death, followed by efficient removal of cell corpses. Professional phagocytes, such as microglia, contribute to the elimination of dead cells. Here we provide evidence that, in addition to their phagocytic activity, microglia promote the death of developing neurons engaged in synaptogenesis. In the developing mouse cerebellum, Purkinje cells die, and 60% of these neurons that already expressed activated caspase-3 were engulfed or contacted by spreading processes emitted by microglial cells. Apoptosis of Purkinje cells in cerebellar slices was strongly reduced by selective elimination of microglia. Superoxide ions produced by microglial respiratory bursts played a major role in this Purkinje cell death. Our study illustrates a mammalian form of engulfment-promoted cell death that links the execution of neuron death to the scavenging of dead cells.

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Research works printed but not linked: 2

  1. Baptista, 1994, Cell-cell interactions influence differentiation of purified Purkinje cells in vitro, Neuron, 2, 243
  2. Fadok, 2001, Phagocyte receptors for apoptotic cells, J. Clin. Invest., 108, 957, 10.1172/JCI200114122 · DOI

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Metadata

Authors
Marı́n-Teva, J. L., Dusart, I., Colin, C., Gervais, A., van Rooijen, N., & Mallat, M.
Affiliations
  • Inserm (FR)
  • Vrije Universiteit Amsterdam (NL)
Corresponding author
Mallat, Michel
ORCID
Venue
Neuron
Publisher
Elsevier BV
Published
2004-02
Volume
41
Issue
4
Pages
535-547
ISSN
0896-6273 (ISSN-L)
DOI
10.1016/s0896-6273(04)00069-8
OpenAlex
W2103711259
Cited by
757
References
82
Citations by year
2026: 13 · 2025: 38 · 2024: 35 · 2023: 45 · 2022: 45 · 2021: 50 · 2020: 30 · 2019: 47 · 2018: 39 · 2017: 29 · 2016: 42 · 2015: 38 · 2014: 42 · 2013: 40 · 2012: 40
FWCI
17.29
Type
journal article
Language
en
Open access
Licence
Locations
  • Neuron (publishedVersion)
  • PubMed (publishedVersion)
  • Pure Amsterdam UMC (publishedVersion)
  • Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion, other-oa)
  • HAL (submittedVersion)
  • Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam) (submittedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
Topics
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Keywords
microglia, Purkinje cells, neuronal apoptosis, cerebellar development, phagocytosis, caspase-3, superoxide, synaptogenesis, neuronal cell death
MeSH terms
Animals, Antibodies, Cell Communication, Cell Differentiation, Cell Survival, Cerebellar Cortex, Enzyme Inhibitors, Mice, Inbred C57BL, Purkinje Cells, Signal Transduction, Free Radical Scavengers, Apoptosis, Microglia, Presynaptic Terminals, Receptors, Tumor Necrosis Factor, Mice, Knockout, Cell Respiration, Caspases, Mice, Caspase 3, In Vitro Techniques

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