Cited by 757Neuroinflammation and Neurodegeneration MechanismsPhagocytosis and Immune RegulationCell death mechanisms and regulation

The DOI matches its Crossref record; 80 of the 82 references it cites were found in a registry or an index.

Microglia Promote the Death of Developing Purkinje Cells

Open access

Marı́n-Teva, José Luis, Dusart, Isabelle, Colin, Catherine, Gervais, Annie, van Rooijen, Nico, Mallat, Michel·2004·Neuron

DOI 10.1016/s0896-6273(04)00069-8

Open this paper in CoChat — free account Open PDF

Abstract

The loss of neuronal cells, a prominent event in the development of the nervous system, involves regulated triggering of programmed cell death, followed by efficient removal of cell corpses. Professional phagocytes, such as microglia, contribute to the elimination of dead cells. Here we provide evidence that, in addition to their phagocytic activity, microglia promote the death of developing neurons engaged in synaptogenesis. In the developing mouse cerebellum, Purkinje cells die, and 60% of these neurons that already expressed activated caspase-3 were engulfed or contacted by spreading processes emitted by microglial cells. Apoptosis of Purkinje cells in cerebellar slices was strongly reduced by selective elimination of microglia. Superoxide ions produced by microglial respiratory bursts played a major role in this Purkinje cell death. Our study illustrates a mammalian form of engulfment-promoted cell death that links the execution of neuron death to the scavenging of dead cells.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/s0896-6273(04)00069-8

Cites

80 of 80 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Emerging roles of caspase-3 in apoptosis
Porter, A. G., & Jänicke, R. U. (1999) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4400476 · Cited by 3,921
Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures.
Bonfoco, E., Krainc, D., Ankarcrona, M., Nicotera, P., & Lipton, S. A. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.16.7162 · Cited by 1,958
Apoptosis in the nervous system
Yuan, J., & Yankner, B. A. (2000) · Nature · doi:10.1038/35037739 · Cited by 1,882
Liposome mediated depletion of macrophages: mechanism of action, preparation of liposomes and applications
van Rooijen, N., & Sanders, A. (1994) · Journal of Immunological Methods · doi:10.1016/0022-1759(94)90012-4 · Cited by 1,763
A blast from the past: clearance of apoptotic cells regulates immune responses
Savill, J., Dransfield, I., Gregory, C. D., & Haslett, C. (2002) · Nature reviews. Immunology · doi:10.1038/nri957 · Cited by 1,574
Caspase structure, proteolytic substrates, and function during apoptotic cell death
Nicholson, D. (1999) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4400598 · Cited by 1,562
Mice lacking the tumour necrosis factor receptor 1 are resistant to IMF-mediated toxicity but highly susceptible to infection by Listeria monocytogenes
Rothe, J., Lesslauer, W., Loetscher, H., Lang, Y., Koebel, P., Köntgen, F., Althage, A., Zinkernagel, R. M., Steinmetz, M., & Bluethmann, H. (1993) · Nature · doi:10.1038/364798a0 · Cited by 1,246
Killing activity of neutrophils is mediated through activation of proteases by K+ flux
Reeves, E. P., Lu, H., Jacobs, H. L., Messina, C. G. M., Bolsover, S., Gabella, G., Potma, E. O., Warley, A., Roes, J., & Segal, A. W. (2002) · Nature · doi:10.1038/416291a · Cited by 1,153
Cytokines and acute neurodegeneration
Allan, S. M., & Rothwell, N. J. (2001) · Nature reviews. Neuroscience · doi:10.1038/35094583 · Cited by 1,145
Activated microglia mediate neuronal cell injury via a nitric oxide mechanism
Chao, C. C., Hu, S., Molitor, T. W., Shaskan, E. G., & Peterson, P. K. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.149.8.2736 · Cited by 1,138
Fundamental Neuroscience
Arbuthnott, G. W. (2000) · Trends in Neurosciences · doi:10.1016/s0166-2236(99)01495-2 · Cited by 1,124
Phagocytosis of Microbes: Complexity in Action
Underhill, D. M., & Ozinsky, A. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.103001.114744 · Cited by 1,124
Mouse model of x-linked chronic granulomatous disease, an inherited defect in phagocyte superoxide production
Pollock, J. D., Williams, D. A., Gifford, M. A. C., Li, L. L., Du, X., Fisherman, J., Orkin, S. H., Doerschuk, C. M., & Dinauer, M. C. (1995) · Nature Genetics · doi:10.1038/ng0295-202 · Cited by 921
Superoxide production in rat hippocampal neurons: selective imaging with hydroethidine
Bindokas, V. P., Jordán, J., Lee, C., & Miller, R. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-04-01324.1996 · Cited by 859
β-Amyloid Stimulation of Microglia and Monocytes Results in TNFα-Dependent Expression of Inducible Nitric Oxide Synthase and Neuronal Apoptosis
Combs, C. K., Karlo, J. C., Kao, S.-C., & Landreth, G. E. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-04-01179.2001 · Cited by 721
The biochemical basis of the NADPH oxidase of phagocytes
Segal, A. W., & Abo, A. (1993) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(93)90051-n · Cited by 622
The respiratory burst oxidase.
Chanock, S. J., Benna, J. E., Smith, R. M., & BABIOR, B. M. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)31418-7 · Cited by 595
Decreased sensitivity to tumour-necrosis factor but normal T-cell development in TNF receptor-2-deficient mice
Erickson, S. L., de Sauvage, F. J., Kikly, K. K., Carver-Moore, K., Pitts-Meek, S., Gillett, N. A., Sheehan, K. C. F., Schreiber, R. D., Goeddel, D. V., & Moore, M. W. (1994) · Nature · doi:10.1038/372560a0 · Cited by 587
Mice lacking inducible nitric oxide synthase are not resistant to lipopolysaccharide-induced death.
Laubach, V. E., Shesely, E. G., Smithies, O., & Sherman, P. A. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.23.10688 · Cited by 580
The role of macrophage/microglia and astrocytes in the pathogenesis of three neurologic disorders: HIV-associated dementia, Alzheimer disease, and multiple sclerosis
Minagar, A., Shapshak, P., Fujimura, R. K., Ownby, R., Heyes, M., & Eisdorfer, C. (2002) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(02)00207-1 · Cited by 536
Phagocyte receptors for apoptotic cells: recognition, uptake, and consequences
Fadok, V. A., Bratton, D. L., & Henson, P. M. (2001) · Journal of Clinical Investigation · doi:10.1172/jci14122 · Cited by 474
Mitochondrial Susceptibility to Oxidative Stress Exacerbates Cerebral Infarction That Follows Permanent Focal Cerebral Ischemia in Mutant Mice with Manganese Superoxide Dismutase Deficiency
Murakami, K., Kondo, T., 川瀬, 誠., Li, Y., Sato, S., Chen, S. F., & Chan, P. H. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-01-00205.1998 · Cited by 467
Murine brain macrophages induce NMDA receptor mediated neurotoxicity in vitro by secreting glutamate
Piani, D., Frei, K., Kim, Q., Cuénod, M., & Fontana, A. (1991) · Neuroscience Letters · doi:10.1016/0304-3940(91)90559-c · Cited by 411
Phosphatidylserine Receptor Is Required for Clearance of Apoptotic Cells
Li, M. O., Sarkisian, M. R., Mehal, W. Z., RAKIC, P. T., & Flavell, R. A. (2003) · Science · doi:10.1126/science.1087621 · Cited by 403
Phagocytosis promotes programmed cell death in C. elegans
Reddien, P. W., Cameron, S., & Horvitz, H. R. (2001) · Nature · doi:10.1038/35084096 · Cited by 354
Complement components of the innate immune system in health and disease in the CNS
Gasque, P., Dean, Y. D., McGreal, E. P., VanBeek, J., & Morgan, B. P. (2000) · Immunopharmacology · doi:10.1016/s0162-3109(00)80302-1 · Cited by 343
Microglia-Derived Nerve Growth Factor Causes Cell Death in the Developing Retina
Frade, J. M., & Barde, Y. (1998) · Neuron · doi:10.1016/s0896-6273(00)80432-8 · Cited by 341
Induction and Activation by Zinc of NADPH Oxidase in Cultured Cortical Neurons and Astrocytes
Noh, K., & Koh, J. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-23-j0001.2000 · Cited by 335
The origin and differentiation of microglial cells during development
Cuadros, M. Á. (1998) · Progress in Neurobiology · doi:10.1016/s0301-0082(98)00035-5 · Cited by 305
A new mutation, gld, that produces lymphoproliferation and autoimmunity in C3H/HeJ mice.
Roths, J. B., Murphy, E. D., & Eicher, E. M. (1984) · The Journal of Experimental Medicine · doi:10.1084/jem.159.1.1 · Cited by 301
Engulfment genes cooperate with ced-3 to promote cell death in Caenorhabditis elegans
Hoeppner, D. J., Hengartner, M. O., & Schnabel, R. (2001) · Nature · doi:10.1038/35084103 · Cited by 295
Organization of projections from the basomedial nucleus of the amygdala: A PHAL study in the rat
Petrovich, G. D., Risold, P., & Swanson, L. W. (1996) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19961021)374:3 · Cited by 291
Transient IGF-I gene expression during the maturation of functionally related central projection neurons
Bondy, C. (1991) · Journal of Neuroscience · doi:10.1523/jneurosci.11-11-03442.1991 · Cited by 288
Manganic Porphyrins Possess Catalase Activity and Protect Endothelial Cells against Hydrogen Peroxide-Mediated Injury
Day, B. J., Fridovich, I., & Crapo, J. D. (1997) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1997.0341 · Cited by 285
Treatment of the adult retina with microglia-suppressing factors retards axotomy-induced neuronal degradation and enhances axonal regeneration in vivo and in vitro
Thanos, S., Mey, J., & Wild, M. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-02-00455.1993 · Cited by 278
A detailed analysis of hydrogen peroxide-induced cell death in primary neuronal culture
Whittemore, E. R., Loo, D. T., Watt, J. A., & Cotmans, C. W. (1995) · Neuroscience · doi:10.1016/0306-4522(95)00108-u · Cited by 268
Programmed Cell Death of Embryonic Motoneurons Triggered through the FAS Death Receptor
Raoul, C., Henderson, C. E., & Pettmann, B. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.147.5.1049 · Cited by 244
A New Superoxide-generating Oxidase in Murine Osteoclasts
Yang, S., Madyastha, P. R., Bingel, S. A., Ries, W. L., & Key, L. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m001004200 · Cited by 226
t NADPH Oxidase Contributes Directly to Oxidative Stress and Apoptosis in Nerve Growth Factor-Deprived Sympathetic Neurons
Tammariello, T. P., Quinn, M. T., & Estus, S. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-01-j0006.2000 · Cited by 224
Cell death in early neural development: beyond the neurotrophic theory
de la Rosa, E. J., & de Pablo, F. (2000) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01628-3 · Cited by 221
Microglia and cell death in the developing mouse cerebellum
Ashwell, K. W. S. (1990) · Developmental Brain Research · doi:10.1016/0165-3806(90)90203-b · Cited by 219
Programmed cell death in the developing human telencephalon
Rakić, S., & Zečević, N. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00153.x · Cited by 209
The inhibition by diphenyleneiodonium and its analogues of superoxide generation by macrophages
Hancock, J. T., & Jones, O. T. (1987) · Biochemical Journal · doi:10.1042/bj2420103 · Cited by 208
NAD(P)H Oxidase 1, a Product of Differentiated Colon Epithelial Cells, Can Partially Replace Glycoprotein 91 phox in the Regulated Production of Superoxide by Phagocytes
Geiszt, M., Lekstrom, K. J., Brenner, S., Hewitt, S. M., Dana, R., Malech, H. L., & Leto, T. L. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.1.299 · Cited by 207
Gp91 phox is the heme binding subunit of the superoxide-generating NADPH oxidase
Yu, L., Quinn, M. T., Cross, A. R., & Dinauer, M. C. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.14.7993 · Cited by 202
Cytotoxic Effect of Brain Macrophages on Developing Neurons
Théry, C., Chamak, B., & Mallat, M. (1991) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1991.tb00050.x · Cited by 190
Self-citation
Purkinje Cell Survival and Axonal Regeneration Are Age Dependent: AnIn VitroStudy
Dusart, I., Airaksinen, M. S., & Sotelo, C. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-10-03710.1997 · Cited by 177
Self-citation
Granule Neuron Regulation of Purkinje Cell Development: Striking a Balance Between Neurotrophin and Glutamate Signaling
Morrison, M. E., & Mason, C. A. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-10-03563.1998 · Cited by 175
Glial cell line-derived neurotrophic factor promotes the survival and morphologic differentiation of Purkinje cells.
Mount, H. T. J., Dean, D., Alberch, J., Dreyfus, C. F., & Black, I. B. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.20.9092 · Cited by 165
Regulation of neuronal survival and death by extracellular signals during development
Davies, A. M. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg254 · Cited by 157
Macrophages induce apoptosis in normal cells in vivo
Diez‐Roux, G., & Lang, R. A. (1997) · Development · doi:10.1242/dev.124.18.3633 · Cited by 153
Measurement and Characterization of Superoxide Generation in Microglial Cells: Evidence for an NADPH Oxidase-Dependent Pathway
Sankarapandi, S., Zweier, J. L., Mukherjee, G., Quinn, M. T., & Huso, D. L. (1998) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1998.0658 · Cited by 136
Early dendritic development of Purkinje cells in the rat cerebellum. A light and electron microscopic study using axonal tracing in ‘in vitro’ slices
Armengol, J. A., & Sotelo, C. (1991) · Developmental Brain Research · doi:10.1016/0165-3806(91)90213-3 · Cited by 135
A method for the selective depletion of perivascular and meningeal macrophages in the central nervous system
Polfliet, M. M. J., Goede, P. H., van Kesteren-Hendrikx, E. M. L., van Rooijen, N., Dijkstra, C. D., & van den Berg, T. K. (2001) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(01)00282-x · Cited by 127
Regulation of Microglial Development: A Novel Role for Thyroid Hormone
Lima, F. R. S., Gervais, A., Colin, C., Izembart, M., Moura‐Neto, V., & Mallat, M. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-06-02028.2001 · Cited by 124
Self-citation
Transient suppression of macrophage functions by liposome-encapsulated drugs
van Rooijen, N., Bakker, J., & Sanders, N. (1997) · Trends in biotechnology · doi:10.1016/s0167-7799(97)01019-6 · Cited by 116
Brain macrophages: neurotoxic or neurotrophic effector cells?
Mallat, M., & Chamak, B. (1994) · Journal of Leukocyte Biology · doi:10.1002/jlb.56.3.416 · Cited by 114
Self-citation
TNFα contributes to the death of NGF-dependent neurons during development
Barker, V., Middleton, G., Davey, F. D., & Davies, A. M. (2001) · Nature Neuroscience · doi:10.1038/nn755 · Cited by 108
The Heme Component of the Neutrophil NADPH Oxidase Complex Is a Target for Aryliodonium Compounds
Doussière, J., Gaillard, J., & Vignais, P. V. (1999) · Biochemistry · doi:10.1021/bi9823481 · Cited by 105
The Purkinje neuron: I. A Golgi study of its development in the mouse and in culture
Hendelman, W. J., & Aggerwal, A. S. (1980) · The Journal of Comparative Neurology · doi:10.1002/cne.901930417 · Cited by 97
Macrophage-mediated corpse engulfment is required for normalDrosophilaCNS morphogenesis
Sears, H. C., Kennedy, C. J., & Garrity, P. (2003) · Development · doi:10.1242/dev.00586 · Cited by 92
Brain-derived neurotrophic factor can act as a pronecrotic factor through transcriptional and translational activation of NADPH oxidase
Kim, S. H., Won, S. J., Sohn, S., Kwon, H. J., Lee, J. Y., Park, J.-H., & Gwag, B. J. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200112131 · Cited by 90
Neurotrophins and cerebellar development.
Lindholm, D., Hamnér, S., & Zirrgiebel, U. (1997) · PubMed · Cited by 81
Survival of Purkinje Cells in Cerebellar Cultures is Increased by Insulin‐like Growth Factor I
Torres‐Alemán, I., Pons, S., & Santos‐Benito, F. F. (1992) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1992.tb00196.x · Cited by 78
Inhibition of Protein Kinase C Prevents Purkinje Cell Death But Does Not Affect Axonal Regeneration
Ghoumari, A. M., Wehrlé, R., Zeeuw, C. I. D., Sotelo, C., & Dusart, I. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-09-03531.2002 · Cited by 77
Self-citation
Immunohistochemical detection of thrombospondin in microglia in the developing rat brain
Chamak, B., Dobbertin, A., & Mallat, M. (1995) · Neuroscience · doi:10.1016/0306-4522(95)00236-c · Cited by 77
Self-citation
Elimination of bax expression in mice increases cerebellar purkinje cell numbers but not the number of granule cells
Fan, H., Favero, M., & Vogel, M. W. (2001) · The Journal of Comparative Neurology · doi:10.1002/cne.1055 · Cited by 77
Electrophysiological studies on the postnatal development of intracerebellar nuclei neurons in rat cerebellar slices maintained in vitro. I. Postsynaptic potentials
Gardette, R., Debono, M., Dupont, J. L., & Crépel, F. (1985) · Developmental Brain Research · doi:10.1016/0165-3806(85)90230-5 · Cited by 77
Implication of Bcl‐2 and Caspase‐3 in age‐related Purkinje cell death in murine organotypic culture: an in vitro model to study apoptosis
Ghoumari, A. M., Wehrlé, R., Bernard, O., Sotelo, C., & Dusart, I. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00186.x · Cited by 75
Self-citation
Fluorescent Dye Prelabelled Microglial Cells Migrate into Organotypic Hippocampal Slice Cultures and Ramify
Hailer, N. P., Heppner, F. L., Haas, D., & Nitsch, R. (1997) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1997.tb01436.x · Cited by 58
Activation of Microglia during Developmentally Regulated Cell Death in the Cerebral Cortex
Upender, M. B., & Naegele, J. R. (1999) · Developmental Neuroscience · doi:10.1159/000017416 · Cited by 54
Ciliary Neurotrophic Factor Enhances the Survival of Purkinje Cells In Vitro
Lärkfors, L., Lindsay, R. M., & Alderson, R. F. (1994) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1994.tb00596.x · Cited by 53
Adenovirus-mediated gene transfer into monocyte-derived macrophages of patients with X-linked chronic granulomatous disease: ex vivo correction of deficient respiratory burst
Schneider, S., Rusconi, S., Seger, R., & Hossle, J. P. (1997) · Gene Therapy · doi:10.1038/sj.gt.3300432 · Cited by 38
Oxidant treatment causes a dose-dependent phenotype of apoptosis in cultured motoneurons
Kaal, E. C. A., Veldman, H., Sodaar, P., Joosten, E. A. J., & Bär, P. R. (1998) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19981215)54:6 · Cited by 37
Process of differentiation of cerebellar Purkinje neurons in the chick embryo
Bertossi, M., Roncali, L., Mancini, L., Ribatti, D., & Nico, B. (1986) · Anatomy and Embryology · doi:10.1007/bf00315453 · Cited by 34
A BLAST from the Past
Donahue, W. F., & Jarrell, K. A. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00429-x · Cited by 33
Haemopoietic phagocytes in the early differentiating avian retina.
Cuadros, M. Á., Garcia-Martin, M., Martin, C., & Ríos, A. (1991) · PubMed · Cited by 33
PHAGOCYTOSIS OF MICROBES
Underhill, D. M., & Ozinsky, A. (2002) · Cited by 17
Broca's region revisited: Cytoarchitecture and intersubject variability
Amunts, K., Schleicher, A., B�rgel, U., Mohlberg, H., Uylings, H. B. M., & Zilles, K. (1999) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19990920)412:2
Self-citation
Untitled work
Zujovic (2000) · doi:10.1002/(sici)1098-1136(20000215)29:4

Research works printed but not linked: 2

Baptista, 1994, Cell-cell interactions influence differentiation of purified Purkinje cells in vitro, Neuron, 2, 243
Fadok, 2001, Phagocyte receptors for apoptotic cells, J. Clin. Invest., 108, 957, 10.1172/JCI200114122 · DOI

Sorted by citations

Synaptic Pruning by Microglia Is Necessary for Normal Brain Development
Paolicelli, R. C., Bolasco, G., Pagani, F., Maggi, L., Scianni, M., Panzanelli, P., Giustetto, M., Ferreira, T. A., Guiducci, E., Dumas, L., et al. (2011) · Science · doi:10.1126/science.1202529 · Cited by 4,244
Microglia-mediated neurotoxicity: uncovering the molecular mechanisms
Block, M. L., Zecca, L., & Hong, J.-S. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2038 · Cited by 4,110
Microglia: Active sensor and versatile effector cells in the normal and pathologic brain
Hanisch, U.-K., & Kettenmann, H. (2007) · Nature Neuroscience · doi:10.1038/nn1997 · Cited by 3,676
Physiology of Microglia
Kettenmann, H., Hanisch, U.-K., Noda, M., & Verkhratsky, A. (2011) · Physiological Reviews · doi:10.1152/physrev.00011.2010 · Cited by 3,547
Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor
Parkhurst, C. N., Yang, G., Ninan, I., Savas, J. N., Yates, J. R., Lafaille, J. J., Hempstead, B. L., Littman, D. R., & Gan, W.-B. (2013) · Cell · doi:10.1016/j.cell.2013.11.030 · Cited by 2,599

See all 757

Authors: Marı́n-Teva, J. L., Dusart, I., Colin, C., Gervais, A., van Rooijen, N., & Mallat, M.
Affiliations: Inserm (FR)
Vrije Universiteit Amsterdam (NL)
Corresponding author: Mallat, Michel
ORCID: Dusart, Isabelle
van Rooijen, Nico
Mallat, Michel
Venue: Neuron
Publisher: Elsevier BV
Published: 2004-02
Volume: 41
Issue: 4
Pages: 535-547
ISSN: 0896-6273 (ISSN-L)
DOI: 10.1016/s0896-6273(04)00069-8
OpenAlex: W2103711259
Cited by: 757
References: 82
Citations by year: 2026: 13 · 2025: 38 · 2024: 35 · 2023: 45 · 2022: 45 · 2021: 50 · 2020: 30 · 2019: 47 · 2018: 39 · 2017: 29 · 2016: 42 · 2015: 38 · 2014: 42 · 2013: 40 · 2012: 40
FWCI: 17.29
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 3454 d)
Locations: Neuron (publishedVersion)
PubMed (publishedVersion)
Pure Amsterdam UMC (publishedVersion)
Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion, other-oa)
HAL (submittedVersion)
Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam) (submittedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
Topics: Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Keywords: microglia, Purkinje cells, neuronal apoptosis, cerebellar development, phagocytosis, caspase-3, superoxide, synaptogenesis, neuronal cell death
MeSH terms: Animals, Antibodies, Cell Communication, Cell Differentiation, Cell Survival, Cerebellar Cortex, Enzyme Inhibitors, Mice, Inbred C57BL, Purkinje Cells, Signal Transduction, Free Radical Scavengers, Apoptosis, Microglia, Presynaptic Terminals, Receptors, Tumor Necrosis Factor, Mice, Knockout, Cell Respiration, Caspases, Mice, Caspase 3, In Vitro Techniques

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Microglia Promote the Death of Developing Purkinje Cells

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks