Cited by 150Protein Kinase Regulation and GTPase SignalingPI3K/AKT/mTOR signaling in cancerProtein Tyrosine Phosphatases

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Regulation of phospholipase C γ isoforms in haematopoietic cells

Wilde, Jonathan I, Watson, Steve P·2001·Cellular Signalling

DOI 10.1016/s0898-6568(01)00191-7

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Abstract

Phospholipase C gamma (PLCgamma) isoforms are critical for the generation of calcium signals in haematopoietic systems in response to the stimulation of immune receptors. PLCgamma is unique amongst phospholipases in that it is tightly regulated by the action of a number of tyrosine kinases. It is itself directly phosphorylated on a number of tyrosines and contains several domains through which it can interact with other signalling proteins and lipid products such as phosphatidylinositol 3,4,5-trisphosphate. Through this network of interactions, PLCgamma is activated and recruited to its substrate, phosphatidylinositol 4,5-bisphosphate, at the membrane. Both isoforms of PLCgamma, PLCgamma1 and PLCgamma2, are present in haematopoietic cells. The signalling cascade involved in the regulation of these two isoforms varies between cells, though the systems are similar for both PLCgamma1 and PLCgamma2. We will compare these cascades for both PLCgamma1 and PLCgamma2 and discuss possible reasons as to why one form of PLCgamma and not the other is required for signalling in specific haematopoietic cells, including T lymphocytes, B lymphocytes, platelets, and mast cells.

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The versatility and universality of calcium signalling
Berridge, M. J., Lipp, P., & Bootman, M. D. (2000) · Nature Reviews Molecular Cell Biology · doi:10.1038/35036035 · Cited by 5,701
Lipid rafts and signal transduction
Simons, K., & Toomre, D. (2000) · Nature Reviews Molecular Cell Biology · doi:10.1038/35036052 · Cited by 5,371
Cell Signaling by Receptor Tyrosine Kinases
Schlessinger, J. (2000) · Cell · doi:10.1016/s0092-8674(00)00114-8 · Cited by 3,774
LAT
Zhang, W., Sloan‐Lancaster, J., Kitchen, J., Trible, R. P., & Samelson, L. E. (1998) · Cell · doi:10.1016/s0092-8674(00)80901-0 · Cited by 1,271
Membrane Compartmentation Is Required for Efficient T Cell Activation
Xavier, R. J., Brennan, T. V., Li, Q. S., McCormack, C., & Seed, B. (1998) · Immunity · doi:10.1016/s1074-7613(00)80577-4 · Cited by 907
Mutation of Unique Region of Bruton's Tyrosine Kinase in Immunodeficient XID Mice
Rawlings, D. J., Saffran, D. C., Tsukada, S., Largaespada, D. A., Grimaldi, J. C., Cohen, L., Mohr, R. N., Bazán, J. F., Howard, M., Copeland, N. G., et al. (1993) · Science · doi:10.1126/science.8332901 · Cited by 859
LAT Palmitoylation
Zhang, W., Trible, R. P., & Samelson, L. E. (1998) · Immunity · doi:10.1016/s1074-7613(00)80606-8 · Cited by 847
Regulation of inositol phospholipid-specific phospholipase C isozymes.
Rhee, S. G., & Choi, K. D. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)42284-3 · Cited by 741
Defective B cell development and function in Btk-deficient mice
Khan, W. N., Alt, F. W., Gerstein, R. M., Malynn, B. A., Larsson, I., Rathbun, G. A., Davidson, L., Müller, S., Kantor, A. B., Herzenberg, L. A., et al. (1995) · Immunity · doi:10.1016/1074-7613(95)90114-0 · Cited by 726
The immunological synapse and the actin cytoskeleton: molecular hardware for T cell signaling
Dustin, M. L., & Cooper, J. A. (2000) · Nature Immunology · doi:10.1038/76877 · Cited by 690

Show all 138 references

Research works printed but not linked: 6

Rhee, 2000, vol. 27, 1
Briddon, 1998, Biochem J, 337, 203
Oda, 2000, Blood, 95, 1663
Pasquet, 1999, Biochem J, 342, 171, 10.1042/bj3420171 · DOI
Pivniouk, 1999, J Clin Invest, 103, 1737
Hope, 1996, Cell, 7, 843

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Authors: Wilde, J. I., & Watson, S. P.
Affiliations: University of Oxford (GB)
Corresponding author: Wilde, Jonathan I
ORCID: Watson, Steve P
Venue: Cellular Signalling
Publisher: Elsevier BV
Published: 2001-10
Volume: 13
Issue: 10
Pages: 691-701
ISSN: 0898-6568 (ISSN-L)
DOI: 10.1016/s0898-6568(01)00191-7
OpenAlex: W109267590
Cited by: 149
References: 138
Citations by year: 2026: 2 · 2025: 4 · 2024: 2 · 2023: 1 · 2022: 3 · 2021: 7 · 2020: 3 · 2019: 1 · 2018: 3 · 2017: 4 · 2016: 7 · 2015: 4 · 2014: 3 · 2013: 6 · 2012: 9
FWCI: 2.45
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Cellular Signalling (publishedVersion)
PubMed (publishedVersion)
Funders: Wellcome Trust
British Heart Foundation
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
Keywords: phospholipase C-gamma, PLCγ1, PLCγ2, hematopoietic cells, calcium signaling, tyrosine kinase regulation, phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 4,5-bisphosphate, T cells, B cells, platelets, mast cells
MeSH terms: Animals, B-Lymphocytes, Blood Cells, Blood Platelets, Isoenzymes, Models, Biological, Type C Phospholipases, Protein-Tyrosine Kinases, T-Lymphocytes, Signal Transduction, Protein Structure, Tertiary, Protein Isoforms, Receptor Protein-Tyrosine Kinases, Macromolecular Substances, Mice, Phospholipase C gamma

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Regulation of phospholipase C γ isoforms in haematopoietic cells

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