The DOI matches its Crossref record; 114 of the 114 references it cites were found in a registry or an index.
Leptin signalling
Abstract
The identification of leptin as the product of the obesity (ob) gene has been followed by extensive research identifying a wide spectrum of physiological effects elicited by this adipose-derived hormone. These effects are mediated via a family of cytokine-like receptor isoforms distributed in both the central nervous system and periphery. The signal transduction pathways regulated by leptin are diverse and include those characteristic of both cytokine and growth factor receptor signalling. This review describes the structure and function of leptin receptors and summarizes recent progress that has been made in characterizing the increasing number of signal transduction pathways regulated by leptin.
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“Elevated circulating levels of leptin, which act via a family of receptor (ob.R) isoforms (335) to mediate an ever-growing wide range of physiological effects (8, 312), are found in obese individuals.”
From Cardiac remodeling in obesity (2008) · cites this paper as [335]
Citations
Cites
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Cited by
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The weight of leptin in immunity
Cava, A. L., & Matarese, G. (2004) · Nature Reviews Immunology · doi:10.1038/nri1350 · Cited by 927
Intracellular signalling pathways activated by leptin
Frühbeck, G. (. (2006) · Deposito Adademico Digital Universidad De Navarra (University of Navarra) · Cited by 745
Abel, E. D., Litwin, S. E., & Sweeney, G. (2008) · Physiological Reviews · doi:10.1152/physrev.00017.2007 · Cited by 736
Self-citationIntracellular signalling pathways activated by leptin
Frühbeck, G. (2005) · Biochemical Journal · doi:10.1042/bj20051578 · Cited by 851
Garofalo, C., & Surmacz, E. (2005) · Journal of Cellular Physiology · doi:10.1002/jcp.20472 · Cited by 597
Metadata
- Authors
- Sweeney, G.
- Affiliations
- York University (CA)
- Corresponding author
- Sweeney, Gary
- ORCID
- Sweeney, Gary
- Venue
- Cellular Signalling
- Publisher
- Elsevier BV
- Published
- 2002-08
- Volume
- 14
- Issue
- 8
- Pages
- 655-663
- ISSN
- 0898-6568 (ISSN-L)
- OpenAlex
- W4247302633
- Cited by
- 271
- References
- 114
- Citations by year
- 2026: 5 · 2025: 2 · 2024: 5 · 2023: 4 · 2022: 4 · 2021: 5 · 2020: 5 · 2019: 5 · 2018: 3 · 2017: 3 · 2016: 8 · 2015: 11 · 2014: 16 · 2013: 16 · 2012: 15
- FWCI
- 2.02
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cellular Signalling (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
- Keywords
- leptin, leptin receptor, signal transduction, obesity-related genes, adipokines, cytokine receptor signalling, central nervous system, periphery
- MeSH terms
- Animals, Nitric Oxide, Phosphoproteins, Proteins, Receptors, Cell Surface, 3',5'-Cyclic-AMP Phosphodiesterases, Signal Transduction, Protein Tyrosine Phosphatases, Protein Serine-Threonine Kinases, Phosphatidylinositol 3-Kinases, Leptin, rho GTP-Binding Proteins, MAP Kinase Signaling System, Intracellular Signaling Peptides and Proteins, Receptors, Leptin, Protein Tyrosine Phosphatase, Non-Receptor Type 11
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