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Coronary heart disease in seven countries
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“In contrast to the high-nitrate diet of Japan, the Seven Countries Study[378] found lower rates of CVD and cancer with the traditional Mediterranean diet, despite 37% of total daily energy coming from fat, versus only 11% in the traditional Japanese diet[378,379].”
From Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health (2017) · cites this paper as [378]
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Items 101–157 of 157
Lemonakis, N., Gikas, E. E., Halabalaki, M., & Skaltsounis, A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0078277 · Cited by 12
Gibson, R., Knight, A., Asante, M., et al. (2015) · Food & Nutrition Research · doi:10.3402/fnr.v59.27790 · Cited by 12
“Our results show that the native Ghanaian diet has a lower fat, saturated, fat and protein content and relies heavily on TGFs and dishes compared to the migrant diet, which relies more heavily on processed ‘Western’ foods and is characterised by higher fat and saturated fat intakes; a nutrient profile known to have de…”
BackgroundAcides gras saturés et risque cardio-métabolique
Lecerf, J. (2016) · Médecine des Maladies Métaboliques · doi:10.1016/s1957-2557(16)30141-9 · Cited by 13
Effect of Olive Oil Consumption on Serum Resistin Concentrations in Healthy Men
Machowetz, A., Gruendel, S., García, A. L., Harsch, I., Covas, M.-I., Zunft, H. ‐., & Koebnick, C. (2008) · Hormone and Metabolic Research · doi:10.1055/s-2008-1078728 · Cited by 11
Cardiovascular disease: a historic perspective.
Smith, D. E. (2000) · PubMed · doi:10.14943/jjvr.48.2-3.147 · Cited by 10
Bioactive lipids: Chemistry, biochemistry, and biological properties
Salsinha, A. S., Machado, M., Rodríguez-Alcalá, L. M., Gomes, A., & Pintado, M. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-824043-4.00014-2 · Cited by 12
Menotti, A., Puddu, P. E., Kafatos, A. G., Tolonen, H. K., Adachi, H., & Jacobs, D. R. (2023) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd10050201 · Cited by 9
“The risk factors measured in all cohorts and used in this analysis were: (1) age, in years approximated to the nearest birthday; (2) physical activity at work, derived from a few questions combined with the reported occupation, and classified as sedentary, moderate or vigorous (in percent), and, in one country, this c…”
InfluentialNutrient Composition of Popularly Consumed African and Caribbean Foods in The UK
Apekey, T. A., Copeman, J., Kime, N. H., Tashani, O. A., Kittaneh, M., Walsh, D., & Maynard, M. J. (2019) · Foods · doi:10.3390/foods8100500 · Cited by 9
“However, the previous notion that dietary SFAs lead to increase in serum cholesterol and thus contribute to the risk of cardiovascular disease risk [45] has been challenged [46].”
BackgroundEnfermedad cardiovascular y grasas: “amigo o villano”
Rubio, M. Á. (2002) · Endocrinología y Nutrición · doi:10.1016/s1575-0922(02)74448-3 · Cited by 9
Hajhashemi, V., Dashti, G., Saberi, S., & Malekjamshidi, P. (2014) · Europe PMC (PubMed Central) · Cited by 10
Comparative effects of plant oils and trans-fat on blood lipid profiles and ischemic stroke in rats
Haiyu, G., Young-Hwan, B., Yeseul, C., et al. (2017) · Journal of Biomedical Research · doi:10.7555/jbr.31.20160095 · Cited by 8
Fat, Sugar or Gut Microbiota in Reducing Cardiometabolic Risk: Does Diet Type Really Matter?
Nabrdalik, K., Krzyżak, K., Hajzler, W., Drożdż, K., Kwiendacz, H., Gumprecht, J., & Lip, G. Y. H. (2021) · Nutrients · doi:10.3390/nu13020639 · Cited by 9
“Since the pioneering SCS, many randomized clinical trials (RCT) and meta-analyses of observational and RCT studies have been conducted.”
InfluentialHypercholesterolemic Effect of Drug-Type Cannabis sativa L. Seed (Marijuana Seed) in Guinea Pig
Hayatghaibi, H., & Karimi, I. (2006) · Pakistan Journal of Nutrition · doi:10.3923/pjn.2007.59.62 · Cited by 7
Modification of gene expression in rat cardiomyocytes by linoleic and docosahexaenoic acids
Cheema, S. K., Tappia, P. S., & Dhalla, N. S. (2018) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2018-0398 · Cited by 7
Hu, G. (2001) · Health Promotion International · doi:10.1093/heapro/16.4.315 · Cited by 6
“Finland had the highest mortality in the world from CVD, in particular coronary heart diseases, at the beginning of the 1970s (Keys, 1970; Uemura and Pisa, 1988).”
BackgroundBerkowitz, L., Araneda, P., Cofré, G., Sara, D., Olsen, M., Urzúa, I., Pérez, D. D., & Rigotti, A. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1728865 · Cited by 8
“In the same decade, the Seven Countries Study led by Ancel Keys promoted increased consumption of LA-rich vegetable oils to lower cholesterol and cardiovascular risk (68), contributing to a dramatic rise in the consumption of these oils in the United States (69).”
Bonassi, S., & Fenech, M. F. (2021) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2021.108390 · Cited by 6
Oleic acid and implications for the Mediterranean diet
Arsić, A. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-818649-7.00024-2 · Cited by 7
Bioactive Phenolic Compounds in Extra Virgin Olive Oil: Implications for Cardiovascular Health
Vázquez‐Jiménez, C., Rodríguez-Pérez, M. D., Ortega-Hombrados, L., Sánchez‐Tévar, A. M., de la Cruz-Cortés, J. P., & Correa, J. A. G. (2026) · Food Science & Nutrition · doi:10.1002/fsn3.71441 · Cited by 6
“These findings led to subsequent research demonstrating that higher consumption of monounsaturated fats, particularly from olive oil, is strongly associated with a reduced incidence of CVDs (Keys 1997).”
InfluentialHuile d’olive et santé osseuse
Coxam, V., Wauquier, F., Darie, C., Spilmont, M., Davicco, M.-J., & Wittrant, Y. (2014) · OCL · doi:10.1051/ocl/2014030 · Cited by 4
“…et al., 2009) et si les vertus de ce régime sont classiquement évoquées pour les maladies cardiovasculaires et certains cancers, les travaux de Keys (1995, 1997) et de Martin-Moreno et al. (1994) en attribuent les effets protecteurs, au moins en partie, à l’huile d’olive qui fournit 37 %, 42…”
BackgroundDieta y prevención de enfermedad coronaria
Rubio, M. Á. (2010) · Clínica e Investigación en Arteriosclerosis · doi:10.1016/s0214-9168(10)70041-3 · Cited by 4
Vitale, E. (2023) · Endocrine Metabolic & Immune Disorders - Drug Targets · doi:10.2174/0118715303256362230926053558 · Cited by 5
Epidemiologic Characterization of Risk for Cardiovascular Diseases
Maki, K. C., Dicklin, M. R., & Nieman, K. M. (2018) · Contemporary cardiology · doi:10.1007/978-3-319-97622-8_1 · Cited by 4
Nutritional and Chemical Quality of Traditional Spreads and Pies of Mediterranean Diet of Greece
Vardavas, C. I. (2013) · Journal of Food & Nutritional Disorders · doi:10.4172/2324-9323.1000105 · Cited by 4
Inadera, H., & Hamazaki, T. (2010) · Nippon Eiseigaku Zasshi (Japanese Journal of Hygiene) · doi:10.1265/jjh.65.506 · Cited by 4
Yang, W.-C., Chen, Y., Wang, C., et al. (2025) · The Breast · doi:10.1016/j.breast.2025.104581 · Cited by 3
Adherence to Mediterranean diet: a public health paradox
Praticò, D. (2026) · International Journal of Food Sciences and Nutrition · doi:10.1080/09637486.2026.2692948 · Cited by 5
“…consuming dietary patterns rich in plant-based foods and olive oil, particularly in Mediterranean regions such as Greece and Southern Italy, exhibited markedly lower rates of coronary heart disease and all-cause mortality compared with Northern European and American populations (Keys 1997).”
MALAVIYA, A. N., Bondge, B., & Prasad, S. (2024) · Indian Journal of Rheumatology · doi:10.1177/09733698241231424 · Cited by 3
Brown, R. B. (2024) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd11090296 · Cited by 4
“Associations of high serum levels of LDL-C with high saturated fat intake, from the Seven Countries Study by Keys, supported the cholesterol hypothesis of atherosclerosis pathology [61,62].”
BackgroundDyslipidemia and Endothelial Dysfunction: Pathophysiology and Therapy
Anderson, T. J., & Charbonneau, F. (2007) · doi:10.1002/9780470988473.ch17 · Cited by 3
Mediterranean Diet in Disease Prevention: Current Perspectives
Fargnoli, J. L., Kim, Y. H., & Mantzoros, C. S. (2009) · Humana Press eBooks · doi:10.1007/978-1-60327-453-1_14 · Cited by 2
“It is scored in terms of eight components: ( 1 ) high ratio of monounsaturated to saturated fats; (2) moderate alcohol consumption; (3) high consumption of legumes; (4) high consumption of cereals; (5) high consumption of fruits; (6) high consumption of vegetables; (7) low consumption of meat and meat products; (8) lo…”
BackgroundEating Out of Home and Risk for Obesity: An Overview
Rotondo, G., Cazzaniga, E., & Palestini, P. (2021) · Acta Scientifci Nutritional Health · doi:10.31080/asnh.2020.05.0818 · Cited by 1
KNOWLEDGE REGARDING NUTRITION, ATTITUDE AND PRACTICE OF SMOKERS AND NON-SMOKERS
Emami, H., Ashkzari, M. S., Naseri, G., NIa, B., Shiraz, A. S. R., & Masjedi, M. R. (2008) · Cited by 2
Atherosclerosis and Mediterranean Diet Polyphenols
Carluccio, M. A., Massaro, M., Scoditti, E., & Caterina, R. D. (2013) · Polyphenols in Human Health and Disease · doi:10.1016/b978-0-12-398456-2.00069-4 · Cited by 2
Preuss, H. G., & Bagchi, D. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-816918-6.00010-x · Cited by 2
Pathogenesis of atherosclerosis: lipid metabolism
Wiklund, O., & Borén, J. (2017) · Oxford University Press eBooks · doi:10.1093/med/9780198755777.003.0011 · Cited by 2
EXERCISE TESTS IN CARDIOLOGY: PAST, PRESENT AND FUTURE. PART II
Петровна, В. В., Киселева, Н. В., & Martsevich, S. Y. (2015) · CARDIOVASCULAR THERAPY AND PREVENTION · doi:10.15829/1728-8800-2015-3-82-88 · Cited by 1
Food Guide Pyramids and the 2005 MyPyramid
Fargnoli, J. L., & Mantzoros, C. S. (2009) · Humana Press eBooks · doi:10.1007/978-1-60327-453-1_10 · Cited by 1
“Concurrently, Finland had both the highest saturated fat intake and highest mortality from ischemic heart disease ( 14 ) . Although the diets of the Japanese and Greeks in the study were both characterized by low saturated fat intake, the total fat intake of Greeks was over four times than that of the Japanese, mainly…”
BackgroundTraditional Cretan Diet and Longevity: Evidence from the Seven Countries Study
Papandreou, C. (2012) · Journal of Nutrition & Food Sciences · doi:10.4172/2155-9600.1000e114 · Cited by 1
Pathogenesis of Atherosclerosis: From Cell Biology to Therapeutics
Orr, A. W., Yurdagul, A., & Patel, B. M. (2014) · Colloquium Series on Integrated Systems Physiology From Molecule to Function · doi:10.4199/c00110ed1v01y201406isp053 · Cited by 1
St Hubert Cholegram, une aide efficace dans la lutte contre le LDL-cholestérol
Breton, S. (2007) · Oléagineux Corps gras Lipides · doi:10.1051/ocl.2007.0146 · Cited by 1
“Ainsi, la relation entre la quantité d’acides gras saturés, le risque cardiovasculaire et le cholestérol sanguin est aujourd’hui clairement démontrée [10-13] tout comme celui du cholestérol alimentaire, même si l’ampleur de son effet est variable [14, 15].”
BackgroundThe Mediterranean diet and cardiovascular disease: An overview
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Inequality of international public health
Crawford, M. A., Galli, C., Simopoulos, A. P., et al. (2002) · The Lancet · doi:10.1016/s0140-6736(02)07417-2 · Cited by 1
Ramos, O. J. Z. (2008) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) · Cited by 1
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Cardiovascular Epidemiology and Characterization of Atherosclerotic Disease Risk Factors
Maki, K. C., & Rubin, M. R. (2010) · Humana Press eBooks · doi:10.1007/978-1-60327-963-5_1
Women’s subjective experiences of food and eating on the island of the ‘Mediterranean diet’
Triliva, S. (2010) · Europe’s Journal of Psychology · doi:10.5964/ejop.v6i4.229
“The Cretan diet has been the subject of study (longitudinal and cross-cultural) for decades now, and the changes in eating habits have been documented systematically (Aravanis, Corcodilas, Dontas, Lekos, & Keys, 1970; Keys, 1997; Keys, et al., 1966).”
BackgroundDesai, S., Devkar, R., Gajaria, T. K., Patel, D., & Ramachandran, A. V. (2013) · EXCLI journal · doi:10.17877/de290r-5471 · Cited by 16
Acceptability, Short Term Impacts, and Relationships of Variables of a Processed Food Module
Corbett, J. (2016) · Digital Commons - URI (University of Rhode Island) · doi:10.23860/thesis-corbett-jacqueline-2016
The Historical North Karelia Project: Commentary From One Who Was There
BLACKBURN, H. W. (2021) · American Journal of Public Health · doi:10.2105/ajph.2020.306090
Žeželj, S. P., Zubalj, N. D., Linšak, D. T., et al. (2023) · Paediatria Croatica · doi:10.13112/pc.2023.2
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Eshriqui, I., & Vívolo, S. R. G. F. (2024) · Editora FIOCRUZ eBooks · doi:10.7476/9786557081891.0026
(2000) · Time to knit · doi:10.1016/s1166-4568(19)30297-9
Incorporating A Hybrid Fuzzy Logic Model in Diet Style Selection
Usanase, N., Ozsahin, D. U., & Ozsahin, D. U. (2025) · Global Journal of Sciences · doi:10.48165/gjs.2025.2204
Yu, K.-L. (2026) · Springer eBooks · doi:10.1007/978-981-95-2141-8_1
Metadata
- Authors
- Keys, A.
- Corresponding author
- Keys, Ancel
- Venue
- Nutrition
- Publisher
- Elsevier BV
- Published
- 1997-03
- Volume
- 13
- Issue
- 3
- Pages
- 249-253
- ISSN
- 0899-9007 (ISSN-L)
- OpenAlex
- W1965972676
- Cited by
- 154
- References
- 0
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 4 · 2023: 7 · 2022: 7 · 2021: 13 · 2020: 7 · 2019: 4 · 2018: 6 · 2017: 6 · 2016: 8 · 2015: 7 · 2014: 7 · 2013: 7 · 2012: 3
- FWCI
- 3.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Medicine › Epidemiology › Healthcare Systems and Public Health
- Keywords
- coronary artery disease, cross-national comparison, dietary factors, cardiovascular risk factors
- MeSH terms
- Coronary Disease, Europe, Humans, Japan, Male, United States, History, 20th Century
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