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Cited by 763

The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.

Risk factors for psychosis in an ultra high-risk group: psychopathology and clinical features

Open access
Yung, Alison R, Phillips, Lisa J, Yuen, Hok Pan, McGorry, Patrick D·2004·Schizophrenia Research
DOI 10.1016/s0920-9964(03)00192-0
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Abstract

The identification of individuals at high risk of developing a psychotic disorder has long been a goal of clinicians because it is thought that early treatment of this group may prevent onset of the disorder. However, little is known of predictive factors of psychosis, even within a high-risk group. This study followed up 104 young people thought to be at 'ultra high risk' for schizophrenia and other psychotic disorders by virtue of having a family history of psychotic disorder combined with some functional decline or the presence of subthreshold or self-limiting psychotic symptoms. All subjects were therefore symptomatic, but not psychotic, at intake. Thirty-six subjects (34.6%) developed frank psychotic symptoms within 12 months. Measures of symptom duration, functioning, disability and psychopathology were made at intake, 6 and 12 months. Poor functioning, long duration of symptoms, high levels of depression and reduced attention were all predictors of psychosis. A combination of family history of psychosis, a recent significant decrease in functioning and recent experience of subthreshold psychotic symptoms was also predictive of psychosis. Combining highly predictive variables yielded a method of psychosis prediction at 12 months with good positive predictive value (80.8%), negative predictive value (81.8%) and specificity (92.6%) and moderate sensitivity (60.0%). Within our symptomatic high-risk group, therefore, it appears possible to identify those individuals who are at particularly high risk of developing a psychotic disorder such as schizophrenia. Given the very high PPV and low false positive rate with this two-step process, it may be justifiable to target these individuals for intensive monitoring of mental state and even low-dose neuroleptic medication or other biological and psychosocial treatments depending on clinical condition. This indicated prevention approach could be further developed and preventive strategies in the psychoses refined.

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Metadata

Authors
Yung, A. R., Phillips, L. J., Yuen, H. P., & McGorry, P. D.
Venue
Schizophrenia Research
Publisher
Elsevier BV
Published
2004-04
Volume
67
Issue
2-3
Pages
131-142
ISSN
0920-9964 (ISSN-L)
DOI
10.1016/s0920-9964(03)00192-0
OpenAlex
W1986504292
Cited by
763
References
13
FWCI
12.46
Type
journal article
Language
en
Open access
green

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