The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Risk factors for psychosis in an ultra high-risk group: psychopathology and clinical features
Open accessAbstract
The identification of individuals at high risk of developing a psychotic disorder has long been a goal of clinicians because it is thought that early treatment of this group may prevent onset of the disorder. However, little is known of predictive factors of psychosis, even within a high-risk group. This study followed up 104 young people thought to be at 'ultra high risk' for schizophrenia and other psychotic disorders by virtue of having a family history of psychotic disorder combined with some functional decline or the presence of subthreshold or self-limiting psychotic symptoms. All subjects were therefore symptomatic, but not psychotic, at intake. Thirty-six subjects (34.6%) developed frank psychotic symptoms within 12 months. Measures of symptom duration, functioning, disability and psychopathology were made at intake, 6 and 12 months. Poor functioning, long duration of symptoms, high levels of depression and reduced attention were all predictors of psychosis. A combination of family history of psychosis, a recent significant decrease in functioning and recent experience of subthreshold psychotic symptoms was also predictive of psychosis. Combining highly predictive variables yielded a method of psychosis prediction at 12 months with good positive predictive value (80.8%), negative predictive value (81.8%) and specificity (92.6%) and moderate sensitivity (60.0%). Within our symptomatic high-risk group, therefore, it appears possible to identify those individuals who are at particularly high risk of developing a psychotic disorder such as schizophrenia. Given the very high PPV and low false positive rate with this two-step process, it may be justifiable to target these individuals for intensive monitoring of mental state and even low-dose neuroleptic medication or other biological and psychosocial treatments depending on clinical condition. This indicated prevention approach could be further developed and preventive strategies in the psychoses refined.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Hamilton, M. (1960) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.23.1.56 · Cited by 32,817
The assessment of anxiety states by rating
HAMILTON, M. (1959) · British Journal of Medical Psychology · doi:10.1111/j.2044-8341.1959.tb00467.x · Cited by 11,455
The Brief Psychiatric Rating Scale.
Overall, J. E., & Gorham, D. R. (1962) · Psychological Reports · doi:10.2466/pr0.1962.10.3.799 · Cited by 11,090
A Rating Scale for Mania: Reliability, Validity and Sensitivity
Young, R. C., Biggs, J. T., Ziegler, V. E., & Meyer, D. A. (1978) · British Journal of Psychiatry · doi:10.1192/bjp.133.5.429 · Cited by 8,744
SCAN: Schedules fonr Clinical Assessment in Neuropsychiatry
Wing, J. K. (1990) · Archives of General Psychiatry · doi:10.1001/archpsyc.1990.01810180089012 · Cited by 2,517
Reducing Risks for Mental Disorders: Frontiers for Preventive Intervention Research
(1994) · doi:10.17226/2139 · Cited by 2,073 · cited 1×
“Indicated prevention refers to clinical intervention in individuals who display these putative markers in the hope that further progression of the illness process can be averted (Mrazek and Haggerty, 1994).”
BackgroundThe Prodromal Phase of First-episode Psychosis: Past and Current Conceptualizations
Yung, A. R., & McGorry, P. D. (1996) · Schizophrenia Bulletin · doi:10.1093/schbul/22.2.353 · Cited by 1,168
Self-citationPsychosis prediction: 12-month follow up of a high-risk ("prodromal") group
Yung, A. R., Phillips, L. J., Yuen, H. P., Francey, S. M., McFarlane, C. A., Hallgren, M., & McGorry, P. D. (2003) · Schizophrenia Research · doi:10.1016/s0920-9964(02)00167-6 · Cited by 1,136
Self-citationMcGorry, P. D., Yung, A. R., Phillips, L. J., Yuen, H. P., Francey, S., Cosgrave, E. M., Germano, D., Bravin, J., McDonald, T., Blair, A., et al. (2002) · Archives of General Psychiatry · doi:10.1001/archpsyc.59.10.921 · Cited by 1,056
Self-citationThe Early Symptoms of Schizophrenia
Chapman, J. (1966) · British Journal of Psychiatry · doi:10.1192/bjp.112.484.225 · Cited by 675
Cited by
The Psychosis High-Risk State: A Comprehensive State-of-the-Art Review
Fusar-Poli, P., Borgwardt, S., Bechdolf, A., Addington, J., Riecher-Rössler, A., Schultze-Lutter, F., Keshavan, M., Wood, S., Ruhrmann, S., Seidman, L. J., et al. (2013) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2013.269 · Cited by 1,483
Self-citationPredicting Psychosis: Meta-analysis of Transition Outcomes in Individuals at High Clinical Risk
Fusar-Poli, P. (2012) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.1472 · Cited by 1,361
Cannon, T. D., Cadenhead, K., Cornblatt, B., Woods, S. W., Addington, J., Walker, E., Seidman, L. J., Perkins, D., Tsuang, M., McGlashan, T., et al. (2008) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2007.3 · Cited by 1,269
Dysconnectivity in schizophrenia: where are we now?
Pettersson-Yeo, W., Allen, P., Benetti, S., McGuire, P., & Mechelli, A. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.11.004 · Cited by 712
Ruhrmann, S., Schultze-Lutter, F., Salokangas, R. K. R., Heinimaa, M., Linszen, D., Dingemans, P., Birchwood, M., Patterson, P., Juckel, G., Heinz, A., et al. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2009.206 · Cited by 632
Pantelis, C. (2005) · Schizophrenia Bulletin · doi:10.1093/schbul/sbi034 · Cited by 573
Wigman, J. T. W., van Nierop, M., Vollebergh, W. A. M., Lieb, R., Beesdo-Baum, K., Wittchen, H.-U., & van Os, J. (2012) · Schizophrenia Bulletin · doi:10.1093/schbul/sbr196 · Cited by 392
Yung, A. R., Nelson, B., Baker, K., Buckby, J. A., Baksheev, G., & Cosgrave, E. M. (2009) · Australian & New Zealand Journal of Psychiatry · doi:10.1080/00048670802607188 · Cited by 371
Self-citationYung, A. R., Nelson, B., Stanford, C., Simmons, M. B., Cosgrave, E. M., Killackey, E., Phillips, L. J., Bechdolf, A., Buckby, J., & McGorry, P. D. (2008) · Schizophrenia Research · doi:10.1016/j.schres.2008.07.012 · Cited by 358
Self-citationEvidence of a dimensional relationship between schizotypy and schizophrenia: A systematic review
Nelson, M. T., Seal, M. L., Pantelis, C., & Phillips, L. J. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.01.004 · Cited by 334
Self-citationPredicting schizophrenia: findings from the Edinburgh High-Risk Study
Johnstone, E. C., Ebmeier, K. P., Miller, P., Owens, D. G. C., & Lawrie, S. M. (2005) · British Journal of Psychiatry · doi:10.1192/bjp.186.1.18 · Cited by 326
Fisher, H. L., Caspi, A., Poulton, R., Meier, M. H., Houts, R., Harrington, H., Arseneault, L., & Moffitt, T. E. (2013) · Psychological Medicine · doi:10.1017/s0033291712003091 · Cited by 307
Yung, A. R., Buckby, J. A., Cotton, S. M., Cosgrave, E. M., Killackey, E. J., Stanford, C., Godfrey, K., & McGorry, P. D. (2006) · Schizophrenia Bulletin · doi:10.1093/schbul/sbj018 · Cited by 264
Social functioning in individuals at clinical high risk for psychosis
Addington, J., Penn, D., Woods, S. W., Addington, D., & Perkins, D. O. (2008) · Schizophrenia Research · doi:10.1016/j.schres.2007.10.001 · Cited by 265
McGorry, P. D., Nelson, B., Markulev, C., Yuen, H. P., Schäfer, M. R., Mossaheb, N., Schlögelhofer, M., Smesny, S., Hickie, I. B., Berger, G. E., et al. (2017) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2016.2902 · Cited by 262
Self-citationPrediction of Functional Outcome in Individuals at Clinical High Risk for Psychosis
Carrión, R. E., McLaughlin, D., Goldberg, T. E., Auther, A. M., Olsen, R. H., Olvet, D. M., Correll, C. U., & Cornblatt, B. A. (2013) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2013.1909 · Cited by 250
Preventing progression to first-episode psychosis in early initial prodromal states
Bechdolf, A., Wagner, M., Ruhrmann, S., Harrigan, S., Putzfeld, V., Pukrop, R., Brockhaus-Dumke, A., Berning, J., Janssen, B., Decker, P., et al. (2012) · British Journal of Psychiatry · doi:10.1192/bjp.bp.109.066357 · Cited by 224
Demjaha, A., Valmaggia, L., Stahl, D., Byrne, M., & McGuire, P. (2012) · Schizophrenia Bulletin · doi:10.1093/schbul/sbq088 · Cited by 194
Longer-term outcome in the prevention of psychotic disorders by the Vienna omega-3 study
Amminger, G. P., Schäfer, M. R., Schlögelhofer, M., Klier, C. M., & McGorry, P. D. (2015) · Nature Communications · doi:10.1038/ncomms8934 · Cited by 188
Self-citationPrediction and Prevention of Psychosis in Youth at Clinical High Risk
Addington, J., & Heinssen, R. (2012) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-032511-143146 · Cited by 189
Prodromal interventions for schizophrenia vulnerability: the risks of being “at risk”
Corcoran, C., Malaspina, D., & Hercher, L. (2005) · Schizophrenia Research · doi:10.1016/j.schres.2004.05.021 · Cited by 183
Preti, A., & Cella, M. (2010) · Schizophrenia Research · doi:10.1016/j.schres.2010.07.026 · Cited by 167
O'Brien, M. P., Gordon, J. L., Bearden, C. E., Lopez, S. R., Kopelowicz, A., & Cannon, T. D. (2006) · Schizophrenia Research · doi:10.1016/j.schres.2005.10.005 · Cited by 155
Prognosis of Brief Psychotic Episodes: A Meta-analysis
Fusar-Poli, P., Cappucciati, M., Bonoldi, I., Hui, L. M. C., Rutigliano, G., Stahl, D. R., Borgwardt, S., Politi, P., Mishara, A. L., Lawrie, S. M., et al. (2016) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2015.2313 · Cited by 151
Ruhrmann, S., Schultze-Lutter, F., & Klosterkötter, J. (2010) · Schizophrenia Research · doi:10.1016/j.schres.2010.03.015 · Cited by 147
Aiello, G., Horowitz, M., Hepgul, N., Pariante, C. M., & Mondelli, V. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.05.003 · Cited by 141
Bechdolf, A., Nelson, B., Cotton, S. M., Chanen, A., Thompson, A., Kettle, J., Conus, P., Amminger, G. P., Yung, A. R., Berk, M., et al. (2010) · Journal of Affective Disorders · doi:10.1016/j.jad.2010.06.016 · Cited by 131
Self-citationGender Differences in Individuals at High‐Risk of Psychosis: A Comprehensive Literature Review
Barajas, A., Ochoa, S., Obiols, J. E., & Lalucat-Jo, L. (2015) · The Scientific World Journal · doi:10.1155/2015/430735 · Cited by 122
Fusar-Poli, P., Rutigliano, G., Stahl, D., Schmidt, A., Ramella-Cravaro, V., Hitesh, S., & McGuire, P. (2016) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2016.2707 · Cited by 121
The prevention of schizophrenia
Yung, A. R., Killackey, E., Hetrick, S. E., Parker, A. G., Schultze-Lutter, F., Klosterkoetter, J., Purcell, R., & Mcgorry, P. D. (2007) · International Review of Psychiatry · doi:10.1080/09540260701797803 · Cited by 104
Self-citationRössler, W., Hengartner, M. P., Ajdacic-Gross, V., Haker, H., Gamma, A., & Angst, J. (2011) · Schizophrenia Research · doi:10.1016/j.schres.2011.06.019 · Cited by 103
Koethe, D., Gerth, C. W., Neatby, M. A., Haensel, A., Thies, M., Schneider, U., Emrich, H. M., Klosterkötter, J., Schultze-Lutter, F., & Leweke, F. M. (2006) · Schizophrenia Research · doi:10.1016/j.schres.2006.07.023 · Cited by 93
Rationale and First Results of Developing At-Risk (Prodromal) Criteria for Bipolar Disorder
Bechdolf, A., Ratheesh, A., J. Wood, S., Tecic, T., Conus, P., Nelson, B., M. Cotton, S., M. Chanen, A., P. Amminger, G., Ruhrmann, S., et al. (2012) · Current Pharmaceutical Design · doi:10.2174/138161212799316226 · Cited by 82
Zanini, M., Castro, J., Coelho, F. M., Bittencourt, L., Bressan, R. A., Tufik, S., & Brietzke, E. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.08.012 · Cited by 69
Hides, L., Lubman, D. I., Buckby, J., Yuen, H. P., Cosgrave, E., Baker, K., & Yung, A. R. (2009) · Schizophrenia Research · doi:10.1016/j.schres.2009.04.001 · Cited by 69
“…high risk of psychosis (UHR; presence of attenuated psychotic symptoms and/or family history) (Cannon et al., 2008; Kristensen and Cadenhead, 2007; Yung et al., 2003, 2004), although two studies have failed to find specific effects for cannabis abuse/dependence (Cannon et al., 2008; Phillips et…”
Abnormalities in sleep patterns in individuals at risk for psychosis and bipolar disorder
Zanini, M. A., Castro, J., Cunha, G. R., Asevedo, E., Pan, P. M., Bittencourt, L., Coelho, F. M., Tufik, S., Gadelha, A., Bressan, R. A., et al. (2015) · Schizophrenia Research · doi:10.1016/j.schres.2015.08.023 · Cited by 64
Ethical, Legal, and Clinical Considerations when Disclosing a High‐Risk Syndrome for Psychosis
Mittal, V. A., Dean, D. J., Mittal, J., & Saks, E. R. (2015) · Bioethics · doi:10.1111/bioe.12155 · Cited by 57
Do the Trajectories of Bipolar Disorder and Schizophrenia Follow a Universal Staging Model?
Duffy, A., Malhi, G. S., & Grof, P. (2017) · The Canadian Journal of Psychiatry · doi:10.1177/0706743716649189 · Cited by 46
Chudleigh, C., Naismith, S. L., Blaszczynski, A., Hermens, D. F., Hodge, M. A. R., & Hickie, I. B. (2011) · Early Intervention in Psychiatry · doi:10.1111/j.1751-7893.2011.00280.x · Cited by 42
Psychosis Risk and Development: What Do We Know From Population-Based Studies?
Mennigen, E., & Bearden, C. E. (2020) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.12.014 · Cited by 40
“Risk factors for subthreshold PS and overt psychotic disorders, include genetic risk, both family history (42,43) and highimpact copy number variations (CNVs) such as 22q11.”
BackgroundBousman, C. A., Yung, A. R., Pantelis, C., Ellis, J. A., Chavez, R. A., Nelson, B., Lin, A., Wood, S. J., Amminger, G. P., Velakoulis, D., et al. (2013) · Translational Psychiatry · doi:10.1038/tp.2013.23 · Cited by 38
Self-citationIncreased pituitary volume in schizophrenia spectrum disorders
Takahashi, T., Suzuki, M., Velakoulis, D., Lorenzetti, V., Soulsby, B., Zhou, S.-Y., Nakamura, K., Seto, H., Kurachi, M., & Pantelis, C. (2009) · Schizophrenia Research · doi:10.1016/j.schres.2008.12.016 · Cited by 37
Bloemen, O. J. N., de Koning, M. B., Gleich, T., Meijer, J., de Haan, L., Linszen, D. H., Booij, J., & van Amelsvoort, T. A. M. J. (2013) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2012.04.015 · Cited by 37
Unterrassner, L., Wyss, T. A., Wotruba, D., Haker, H., & Rössler, W. (2017) · Frontiers in Psychology · doi:10.3389/fpsyg.2017.01537 · Cited by 35
Dhiman, S., Mannan, A., Taneja, A., Mohan, M., & Singh, T. G. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.122537 · Cited by 25
Preventing discrimination based on psychiatric risk biomarkers
Brannan, C., Foulkes, A. L., & Lázaro‐Muñoz, G. (2019) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32629 · Cited by 22
Shields, G. E., Buck, D., Varese, F., Yung, A. R., Thompson, A., Husain, N., Broome, M. R., Upthegrove, R., Byrne, R., & Davies, L. M. (2022) · BMC Psychiatry · doi:10.1186/s12888-022-03769-7 · Cited by 16
Self-citationKrijnen, L. J. G., Lemmers-Jansen, I. L. J., Fett, A.-K. J., & Krabbendam, L. (2021) · Frontiers in Psychology · doi:10.3389/fpsyg.2021.769091 · Cited by 13
Garner, B., Pariante, C. M., Wood, S. J., Velakoulis, D., Phillips, L., Soulsby, B., Brewer, W. J., Smith, D. J., Dazzan, P., Berger, G. E., et al. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.04.018 · Cited by 8
Self-citation
Metadata
- Authors
- Yung, A. R., Phillips, L. J., Yuen, H. P., & McGorry, P. D.
- Venue
- Schizophrenia Research
- Publisher
- Elsevier BV
- Published
- 2004-04
- Volume
- 67
- Issue
- 2-3
- Pages
- 131-142
- ISSN
- 0920-9964 (ISSN-L)
- OpenAlex
- W1986504292
- Cited by
- 763
- References
- 13
- FWCI
- 12.46
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
