hRAD30 Mutations in the Variant Form of Xeroderma Pigmentosum

Xeroderma pigmentosum cells with normal levels of excision repair have a defect in DNA synthesis after UV-irradiation

Lehman, A. R., Kirk-Bell, S., Arlett, C. F., Paterson, M. C., Lohman, P. H., de Weerd-Kastelein, E. A., & Bootsma, D. (1975) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.72.1.219 · Cited by 614 · see citing works

Genome maintenance mechanisms for preventing cancer

Hoeijmakers, J. H. J. (2001) · Nature · doi:10.1038/35077232 · Cited by 3,939 · see citing works

DNA repair pathways as targets for cancer therapy

Helleday, T., Petermann, E., Lundin, C., Hodgson, B., & Sharma, R. A. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2342 · Cited by 1,666 · see citing works

DNA Replication Fidelity

Kunkel, T. A., & Bebenek, K. (2000) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.69.1.497 · Cited by 1,003 · see citing works

Interaction of Human DNA Polymerase η with Monoubiquitinated PCNA

Kannouche, P. L., Wing, J., & Lehmann, A. R. (2004) · Molecular Cell · doi:10.1016/s1097-2765(04)00259-x · Cited by 845 · see citing works

Error-Prone Repair DNA Polymerases in Prokaryotes and Eukaryotes

Goodman, M. F. (2002) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.71.083101.124707 · Cited by 727 · see citing works

Y-family DNA polymerases and their role in tolerance of cellular DNA damage

Sale, J. E., Lehmann, A. R., & Woodgate, R. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3289 · Cited by 665 · see citing works

Eukaryotic polymerases ι and ζ act sequentially to bypass DNA lesions

Johnson, R. E., Washington, M. T., Haracska, L., Prakash, S., & Prakash, L. (2000) · Nature · doi:10.1038/35023030 · Cited by 632 · see citing works

Eukaryotic Translesion Polymerases and Their Roles and Regulation in DNA Damage Tolerance

Waters, L. S., Minesinger, B. K., Wiltrout, M. E., D'Souza, S., Woodruff, R. V., & Walker, G. C. (2009) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00034-08 · Cited by 591 · see citing works

Shining a light on xeroderma pigmentosum

DiGiovanna, J. J., & Kraemer, K. H. (2012) · Journal of Investigative Dermatology · doi:10.1038/jid.2011.426 · Cited by 547 · see citing works

Mechanisms of accurate translesion synthesis by human DNA polymerase η

Masutani, C., Kusumoto, R., Iwai, S., & Hanaoka, F. (2000) · The EMBO Journal · doi:10.1093/emboj/19.12.3100 · Cited by 504 · see citing works

UV wavelength-dependent DNA damage and human non-melanoma and melanoma skin cancer

Pfeifer, G. P., & Besaratinia, A. (2012) · Photochemical & Photobiological Sciences · doi:10.1039/c1pp05144j · Cited by 473 · see citing works

Cancer in xeroderma pigmentosum and related disorders of DNA repair

Cleaver, J. E. (2005) · Nature Reviews Cancer · doi:10.1038/nrc1652 · Cited by 427 · see citing works

DNA polymerase η is an A-T mutator in somatic hypermutation of immunoglobulin variable genes

Zeng, X., Winter, D. B., Kasmer, C., Kraemer, K. H., Lehmann, A. R., & Gearhart, P. J. (2001) · Nature Immunology · doi:10.1038/88740 · Cited by 420 · see citing works

Recombinational DNA repair and human disease

Thompson, L. H., & Schild, D. (2002) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/s0027-5107(02)00224-5 · Cited by 417 · see citing works

Translesion synthesis: Y-family polymerases and the polymerase switch

LEHMANN, A., NIIMI, A., OGI, T., BROWN, S., SABBIONEDA, S., WING, J., KANNOUCHE, P., & GREEN, C. (2007) · DNA Repair · doi:10.1016/j.dnarep.2007.02.003 · Cited by 389 · see citing works

Low fidelity DNA synthesis by human DNA polymerase-η

Matsuda, T., Bebenek, K., Masutani, C., Hanaoka, F., & Kunkel, T. A. (2000) · Nature · doi:10.1038/35010014 · Cited by 372 · see citing works

Nucleotide Excision Repair

Reardon, J. T., & Sancar, A. (2005) · Progress in Nucleic Acid Research and Molecular Biology · doi:10.1016/s0079-6603(04)79004-2 · Cited by 350 · see citing works

Translesion DNA synthesis in eukaryotes: A one- or two-polymerase affair

Prakash, S., & Prakash, L. (2002) · Genes & Development · doi:10.1101/gad.1009802 · Cited by 344 · see citing works

Translesion DNA Polymerases

Goodman, M. F., & Woodgate, R. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a010363 · Cited by 317 · see citing works

polι, a remarkably error-prone human DNA polymerase

Tissier, A., McDonald, J. P., Frank, E. G., & Woodgate, R. (2000) · Genes & Development · doi:10.1101/gad.14.13.1642 · Cited by 315 · see citing works

Somatic mutation hotspots correlate with DNA polymerase η error spectrum

Rogozin, I. B., Pavlov, Y. I., Bebenek, K., Matsuda, T., & Kunkel, T. A. (2001) · Nature Immunology · doi:10.1038/88732 · Cited by 298 · see citing works

Translesion DNA Synthesis and Mutagenesis in Eukaryotes

Sale, J. E. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a012708 · Cited by 282 · see citing works

Two-polymerase mechanisms dictate error-free and error-prone translesion DNA synthesis in mammals

Shachar, S., Ziv, O., Avkin, S., Adar, S., Wittschieben, J., Reißner, T., Chaney, S., Friedberg, E. C., Wang, Z., Carell, T., et al. (2009) · The EMBO Journal · doi:10.1038/emboj.2008.281 · Cited by 284 · see citing works

Molecular Mechanisms of DNA Damage and Repair: Progress in Plants

Tuteja, N., Singh, M. B., Misra, M. K., Bhalla, P. L., & Tuteja, R. (2001) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/20014091074219 · Cited by 272 · see citing works

Preferential cis–syn thymine dimer bypass by DNA polymerase η occurs with biased fidelity

McCulloch, S. D., Kokoska, R. J., Masutani, C., Iwai, S., Hanaoka, F., & Kunkel, T. A. (2004) · Nature · doi:10.1038/nature02352 · Cited by 246 · see citing works

How DNA lesions are turned into mutations within cells?

Pagès, V., & Fuchs, R. P. (2002) · Oncogene · doi:10.1038/sj.onc.1206006 · Cited by 237 · see citing works

The Human Tim/Tipin Complex Coordinates an Intra-S Checkpoint Response to UV That Slows Replication Fork Displacement

Ünsal-Kaçmaz, K., Chastain, P. D., Qu, P.-P., Minoo, P., Cordeiro-Stone, M., Sancar, A., & Kaufmann, W. K. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.02190-06 · Cited by 240 · see citing works

Replication of a cis–syn thymine dimer at atomic resolution

Ling, H., Boudsocq, F., Plosky, B. S., Woodgate, R., & Yang, W. (2003) · Nature · doi:10.1038/nature01919 · Cited by 216 · see citing works

UV-induced replication arrest in the xeroderma pigmentosum variant leads to DNA double-strand breaks, γ-H2AX formation, and Mre11 relocalization

Limoli, C. L., Giedzinski, E., Bonner, W. M., & Cleaver, J. E. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.231611798 · Cited by 210 · see citing works

Deep phenotyping of 89 xeroderma pigmentosum patients reveals unexpected heterogeneity dependent on the precise molecular defect

Fassihi, H., Sethi, M., Fawcett, H., Wing, J., Chandler, N., Mohammed, S., Craythorne, E., Morley, A. M. S., Lim, R., Turner, S., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1519444113 · Cited by 199 · see citing works

Preferential Incorporation of G Opposite Template T by the Low-Fidelity Human DNA Polymerase ι

Zhang, Y., Yuan, F., Wu, X., & Wang, Z. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.19.7099-7108.2000 · Cited by 200 · see citing works

Fidelity and Processivity of Saccharomyces cerevisiae DNA Polymerase η

Washington, M. T., Johnson, R. E., Prakash, S., & Prakash, L. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.52.36835 · Cited by 181 · see citing works

Structural Insights into the Origins of DNA Polymerase Fidelity

Beard, W. A., & Wilson, S. H. (2003) · Structure · doi:10.1016/s0969-2126(03)00051-0 · Cited by 157 · see citing works

Nucleotide excision repair and cancer

Leibeling, D., Laspe, P., & Emmert, S. (2006) · Journal of Molecular Histology · doi:10.1007/s10735-006-9041-x · Cited by 164 · see citing works

PCNA Ubiquitination Is Important, But Not Essential for Translesion DNA Synthesis in Mammalian Cells

Hendel, A., Krijger, P. H. L., Diamant, N., Goren, Z., Langerak, P., Kim, J., Reißner, T., Lee, K.-Y., Geacintov, N. E., Carell, T., et al. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002262 · Cited by 132 · see citing works

Factors that influence the mutagenic patterns of DNA adducts from chemical carcinogens

Seo, K.-Y., Jelinsky, S. A., & Loechler, E. L. (2000) · Mutation Research/Reviews in Mutation Research · doi:10.1016/s1383-5742(00)00047-8 · Cited by 126 · see citing works

Functions of human DNA polymerases η, κ and ι suggested by their properties, including fidelity with undamaged DNA templates

Kunkel, T. A., Pavlov, Y. I., & Bebenek, K. (2003) · DNA Repair · doi:10.1016/s1568-7864(02)00224-0 · Cited by 125 · see citing works

Yeast DNA Polymerase η Utilizes an Induced-Fit Mechanism of Nucleotide Incorporation

Washington, M. T., Prakash, L., & Prakash, S. (2001) · Cell · doi:10.1016/s0092-8674(01)00613-4 · Cited by 123 · see citing works

Evidence that in Xeroderma Pigmentosum Variant Cells, which Lack DNA Polymerase η, DNA Polymerase ι Causes the Very High Frequency and Unique Spectrum of UV-Induced Mutations

Wang, Y., Woodgate, R., McManus, T. P., Mead, S., McCormick, J. J., & Maher, V. M. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-3073 · Cited by 120 · see citing works

Replication of damaged DNA: molecular defect in xeroderma pigmentosum variant cells

Cordonnier, A. M., & Fuchs, R. P. P. (1999) · Mutation Research/DNA Repair · doi:10.1016/s0921-8777(99)00047-6 · Cited by 113 · see citing works

Lesion bypass in yeast cells: Pol η participates in a multi‐DNA polymerase process

Bresson, A., & Fuchs, R. P. P. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf363 · Cited by 112 · see citing works

DNA damage bypass operates in the S and G2 phases of the cell cycle and exhibits differential mutagenicity

Diamant, N., Hendel, A., Vered, I., Carell, T., Reißner, T., de Wind, N., Geacinov, N., & Livneh, Z. (2012) · Nucleic Acids Research · doi:10.1093/nar/gkr596 · Cited by 109 · see citing works

Relationship of neurologic degeneration to genotype in three xeroderma pigmentosum group G patients

Emmert, S., Slor, H., Busch, D. B., Batko, S., Albert, R. B., Coleman, D., Khan, S. G., Abu-Libdeh, B., DiGiovanna, J. J., Cunningham, B. B., et al. (2002) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2002.01782.x · Cited by 111 · see citing works

DNA Polymerase η, the Product of the Xeroderma Pigmentosum Variant Gene and a Target of p53, Modulates the DNA Damage Checkpoint and p53 Activation

Liu, G., & Chen, X. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.4.1398-1413.2006 · Cited by 104 · see citing works

Increased Susceptibility to UV-Induced Skin Carcinogenesis in Polymerase η–deficient Mice

Lin, Q., Clark, A. B., McCulloch, S. D., Yuan, T., Bronson, R. T., Kunkel, T. A., & Kucherlapati, R. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-1862 · Cited by 95 · see citing works

Molecular genetics of xeroderma pigmentosum variant

Gratchev, A., Strein, P., Utikal, J., & Goerdt, S. (2003) · Experimental Dermatology · doi:10.1034/j.1600-0625.2003.00124.x · Cited by 83 · see citing works

Xeroderma pigmentosum genes: Functions inside and outside DNA repair

Sugasawa, K. (2007) · Carcinogenesis · doi:10.1093/carcin/bgm282 · Cited by 83 · see citing works

ATR/Chk1 pathway is essential for resumption of DNA synthesis and cell survival in UV-irradiated XP variant cells

Despras, E., Daboussi, F., Hyrien, O., Marheineke, K., & Kannouche, P. L. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq046 · Cited by 80 · see citing works

Structure-based interpretation of missense mutations in Y-family DNA polymerases and their implications for polymerase function and lesion bypass

Boudsocq, F. (2002) · DNA Repair · doi:10.1016/s1568-7864(02)00019-8 · Cited by 79 · see citing works

UV-DDB-dependent regulation of nucleotide excision repair kinetics in living cells

Nishi, R., Alekseev, S., Dinant, C., Hoogstraten, D., Houtsmuller, A. B., Hoeijmakers, J. H. J., Vermeulen, W., Hanaoka, F., & Sugasawa, K. (2009) · DNA Repair · doi:10.1016/j.dnarep.2009.02.004 · Cited by 76 · see citing works

Proofreading of DNA Polymerase η-dependent Replication Errors

Bebenek, K., Matsuda, T., Masutani, C., Hanaoka, F., & Kunkel, T. A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c000690200 · Cited by 76 · see citing works

USP7 is a suppressor of PCNA ubiquitination and oxidative-stress-induced mutagenesis in human cells.

Kashiwaba, S.-I., Kanao, R., Masuda, Y., Kusumoto-Matsuo, R., Hanaoka, F., & Masutani, C. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.11.014 · Cited by 71 · see citing works

Requirement of Watson-Crick Hydrogen Bonding for DNA Synthesis by Yeast DNA Polymerase η

Washington, M. T., Helquist, S. A., Kool, E. T., Prakash, L., & Prakash, S. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.14.5107-5112.2003 · Cited by 75 · see citing works

Translesion DNA Polymerases and Cancer

Makridakis, N. M., & Reichardt, J. K. V. (2012) · Frontiers in Genetics · doi:10.3389/fgene.2012.00174 · Cited by 70 · see citing works

Yeast Rev1 is cell cycle regulated, phosphorylated in response to DNA damage and its binding to chromosomes is dependent upon MEC1

Sabbioneda, S., Bortolomai, I., Giannattasio, M., Plevani, P., & Muzi-Falconi, M. (2007) · DNA Repair · doi:10.1016/j.dnarep.2006.09.002 · Cited by 65 · see citing works

Genomic structure, chromosomal localization and identification of mutations in the xeroderma pigmentosum variant (XPV) gene

Yuasa, M., Masutani, C., Eki, T., & Hanaoka, F. (2000) · Oncogene · doi:10.1038/sj.onc.1203842 · Cited by 61 · see citing works

Xeroderma pigmentosum variant and error-prone DNA polymerases

Kannouche, P. (2003) · Biochimie · doi:10.1016/j.biochi.2003.10.009 · Cited by 60 · see citing works

Identification of novel DNA-damage tolerance genes reveals regulation of translesion DNA synthesis by nucleophosmin

Ziv, O., Zeisel, A., Mirlas-Neisberg, N., Swain, U., Nevo, R., Ben-Chetrit, N., Martelli, M. P., Rossi, R., Schiesser, S., Canman, C. E., et al. (2014) · Nature Communications · doi:10.1038/ncomms6437 · Cited by 59 · see citing works

DNA polymerase eta is targeted by Mdm2 for polyubiquitination and proteasomal degradation in response to ultraviolet irradiation.

Jung, Y.-S., Qian, Y., & Chen, X. (2012) · DNA Repair · doi:10.1016/j.dnarep.2011.10.017 · Cited by 57 · see citing works

Phosphorylated HBO1 at UV irradiated sites is essential for nucleotide excision repair

Niida, H., Matsunuma, R., Horiguchi, R., Uchida, C., Nakazawa, Y., Motegi, A., Nishimoto, K., Sakai, S., Ohhata, T., Kitagawa, K., et al. (2017) · Nature Communications · doi:10.1038/ncomms16102 · Cited by 44 · see citing works

Activation of the Fanconi Anemia/BRCA Pathway and Recombination Repair in the Cellular Response to Solar Ultraviolet Light

Dunn, J., Potter, M., Rees, A., & Rünger, T. M. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-0563 · Cited by 42 · see citing works

DNA polymerase <b>η</b> mutational signatures are found in a variety of different types of cancer

Rogozin, I. B., Goncearenco, A., Lada, A. G., De, S., Yurchenko, V., Nudelman, G., Panchenko, A. R., Cooper, D. N., & Pavlov, Y. I. (2018) · Cell Cycle · doi:10.1080/15384101.2017.1404208 · Cited by 39 · see citing works

Requirement for functional DNA polymerase eta in genome-wide repair of UV-induced DNA damage during S phase

Auclair, Y., Rouget, R., Belisle, J. M., Costantino, S., & Drobetsky, E. A. (2010) · DNA Repair · doi:10.1016/j.dnarep.2010.03.013 · Cited by 34 · see citing works

Nucleotide excision repair and related human diseases

Bergoglio, V., & Magnaldo, T. (2006) · Genome Dynamics · doi:10.1159/000092499 · Cited by 25 · see citing works

DNA Lesion Bypass Polymerases Open Up

Beard, W. A., & Wilson, S. H. (2001) · Structure · doi:10.1016/s0969-2126(01)00646-3 · Cited by 25 · see citing works

Historical Aspects of Xeroderma Pigmentosum and Nucleotide Excision Repair

Cleaver, J. E. (2008) · Advances in Experimental Medicine and Biology · doi:10.1007/978-0-387-09599-8_1 · Cited by 13 · see citing works

Adenovirus mediated transduction of the human DNA polymerase eta cDNA

Lima-Bessa, K. M., Chiganças, V., Stary, A., Kannouche, P., Sarasin, A., Armelini, M. G., de Fátima Jacysyn, J., Amarante-Mendes, G. P., Cordeiro-Stone, M., Cleaver, J. E., et al. (2006) · DNA Repair · doi:10.1016/j.dnarep.2006.05.037 · Cited by 11 · see citing works