The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Antimicrobial and antiviral activities of polyphenolics from Cocos nucifera Linn. (Palmae) husk fiber extract
Open accessAbstract
The decoction of Cocos nucifera L. husk fiber has been used in northeastern Brazil traditional medicine for treatment of diarrhea and arthritis. Water extract obtained from coconut husk fiber and fractions from adsorption chromatography revealed antimicrobial activity against Staphylococcus aureus. The crude extract and one of the fractions rich in catechin also showed inhibitory activity against acyclovir-resistant herpes simplex virus type 1 (HSV-1-ACVr). All fractions were inactive against the fungi Candida albicans, Fonsecaea pedrosoi and Cryptococcus neoformans. Catechin and epicatechin together with condensed tannins (B-type procyanidins) were demonstrated to be the components of the water extract.
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In the citing paper
“Cellular studies have also shown that monolaurin exhibits antiviral and antifungal activity [78].”
From Anti-Inflammatory and Skin Barrier Repair Effects of Topical Application of Some Plant Oils (2017) · cites this paper as [78]
In the citing paper
“Meneguetti et al. (2017) and Esquenazi et al. (2002) reported the presence of several phenolic compounds in coconut including Catechin and salicylic acid in the CW and gallic, caffeic, salicylic, and p-coumaric acids in the meat.”
From The use of High-Pressure Processing (HPP) to improve the safety and quality of raw coconut (Cocos nucifera L) water (2020) · cites this paper as Esquenazi et al. (2002)
In the citing paper
“Others have reported antiviral and antibacterial activities due to the presence of lauric acid and other antimicrobial components (Cruz et al., 2014;Esquenazi et al., 2002;Meneguetti et al., 2017;Sarika and Rai, 2012;Sheri et al., 2006).”
From The use of High-Pressure Processing (HPP) to improve the safety and quality of raw coconut (Cocos nucifera L) water (2020) · cites this paper as Esquenazi et al., 2002
In the citing paper
“In Brazil, extract from the husk fiber of C. nucifera is used to treat diarrhea (7).”
From Cocos nucifera (L.) (Arecaceae): A phytochemical and pharmacological review (2015) · cites this paper as [7]
In the citing paper
“The antifungal, antimicrobial, and antiviral effects were attributed to condensed tannins and catechins present in the crude extract and fractions II-V, especially fraction II, which had a higher concentration of these compounds.”
From Cocos nucifera (L.) (Arecaceae): A phytochemical and pharmacological review (2015) · cites this paper as [7]
In the citing paper
“Antiviral action was only seen with the crude extract and fraction II.”
From Cocos nucifera (L.) (Arecaceae): A phytochemical and pharmacological review (2015) · cites this paper as [7]
In the citing paper
“Antifungal activity was demonstrated as growth inhibition of Candida albicans, Cryptococcus neoformans or Fonsecaea pedrosoi.”
From Cocos nucifera (L.) (Arecaceae): A phytochemical and pharmacological review (2015) · cites this paper as [7]
In the citing paper
“The lyophilized extract and fractions, as well as ethyl acetate extracts, from the C. nucifera fiber are rich in polyphenols, compounds such as catechins, epicatechins, tannins, and flavonoids (7,33–35).”
From Cocos nucifera (L.) (Arecaceae): A phytochemical and pharmacological review (2015) · cites this paper as [7]
In the citing paper
“In studies with crude extract and five TLC fractions (I-V) of fiber mesocarp of C. nucifera fruit, in vitro antimicrobial activity was seen in all trial strains of S. aureus tested with fractions II-V (7).”
From Cocos nucifera (L.) (Arecaceae): A phytochemical and pharmacological review (2015) · cites this paper as [7]
Citations
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Cited by
Sorted by citations
Anti-Inflammatory and Skin Barrier Repair Effects of Topical Application of Some Plant Oils
Lin, T.-K., Zhong, L., & Santiago, J. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms19010070 · Cited by 759
“Cellular studies have also shown that monolaurin exhibits antiviral and antifungal activity [78].”
BackgroundAgro-industrial potential of exotic fruit byproducts as a source of food additives
Ayala-Zavala, J. F., Vega-Vega, V., Domínguez, C. R., Palafox-Carlos, H., Villa-Rodríguez, J. A., Siddiqui, M. W., Dávila-Aviña, J., & González-Aguilar, G. A. (2011) · Food Research International · doi:10.1016/j.foodres.2011.02.021 · Cited by 628
Coconut (Cocos nucifera L.: Arecaceae): in health promotion and disease prevention
DebMandal, M., & Mandal, S. (2011) · Asian Pacific Journal of Tropical Medicine · doi:10.1016/s1995-7645(11)60078-3 · Cited by 601
Viral hijacking of cellular metabolism
Thaker, S. K., Ch’ng, J., & Christofk, H. R. (2019) · BMC Biology · doi:10.1186/s12915-019-0678-9 · Cited by 535
Antibacterial, antifungal, and antiviral activities of some flavonoids
Orhan, D. D., Özçelık, B., Özgen, S., & Ergün, F. (2009) · Microbiological Research · doi:10.1016/j.micres.2009.09.002 · Cited by 502
Metadata
- Authors
- Esquenazi, D., Wigg, M. D., Miranda, M. M. F. S., Rodrigues, H. M., Tostes, J. B. F., Rozental, S., da Silva, A. J. R., & Alviano, C. S.
- Affiliations
- Universidade Federal do Rio de Janeiro (BR)
- Corresponding author
- Esquenazi, Daniele
- ORCID
- Alviano, Celuta S.
- Venue
- Research in Microbiology
- Publisher
- Elsevier BV
- Published
- 2002-12
- Volume
- 153
- Issue
- 10
- Pages
- 647-652
- ISSN
- 0769-2609 (ISSN-L)
- 0923-2508
- OpenAlex
- W2073056737
- Cited by
- 291
- References
- 36
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 7 · 2023: 20 · 2022: 19 · 2021: 18 · 2020: 17 · 2019: 17 · 2018: 18 · 2017: 9 · 2016: 18 · 2015: 16 · 2014: 7 · 2013: 15 · 2012: 17
- FWCI
- 2.14
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Research in Microbiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Coconut Research and Applications
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Life Sciences › Agricultural and Biological Sciences › Food Science › Essential Oils and Antimicrobial Activity
- Keywords
- Cocos nucifera, coconut husk fiber, polyphenols, catechins, epicatechin, procyanidins, proanthocyanidins, antimicrobial activity, antiviral activity, Staphylococcus aureus, herpes simplex virus type 1, acyclovir resistance, Candida albicans, Fonsecaea pedrosoi, Cryptococcus neoformans, traditional medicine, decoction
- MeSH terms
- Animals, Anti-Infective Agents, Anti-Bacterial Agents, Antiviral Agents, Catechin, Chlorocebus aethiops, Chromatography, High Pressure Liquid, Cocos, Flavonoids, Humans, Phenols, Plant Extracts, Polymers, Staphylococcus aureus, Vero Cells, Herpesvirus 1, Human
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