P.3.026 Intranasal oxytocin in patients with post traumatic stress disorder: a single dose, pilot double blind crossover study
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In 18 PTSD patients, a reduction in anxiety, restlessness, irritability and even acute PTSD symptoms was found 50 minutes after a single dose of oxytocin compared to placebo treatment.
“In 18 PTSD patients a reduction in anxiety, restlessness, irritability and even acute PTSD symptoms was found 50 minutes after a single dose of oxytocin compared to placebo treatment [55].”
From Efficacy of oxytocin administration early after psychotrauma in preventing the development of PTSD: study protocol of a randomized controlled trial (2014) · cites this paper as [55]
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Bakermans-Kranenburg, M. J., & van IJzendoorn, M. H. (2013) · Translational Psychiatry · doi:10.1038/tp.2013.34 · Cited by 383 · see citing works
Prosocial effects of oxytocin and clinical evidence for its therapeutic potential
Striepens, N., Kendrick, K. M., Maier, W., & Hurlemann, R. (2011) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2011.07.001 · Cited by 283 · see citing works
“…reduced dysphoric stress response in patients with BPD after the Trier Social Stress Task Double-blind, placebo-controlled, within-subject design Yatzkar and Klein 2010 [217] 18 M 0 Not mentioned – OXT reduced the severity of PTSD symptoms, improved mood and reduced thoughts about the…”
BackgroundSartori, S. B., & Singewald, N. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2019.107402 · Cited by 236 · see citing works
Bonding after trauma: on the role of social support and the oxytocin system in traumatic stress
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van Zuiden, M., Kavelaars, A., Geuze, E., Olff, M., & Heijnen, C. J. (2012) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2012.08.015 · Cited by 125 · see citing works
Koch, S. B. J., van Zuiden, M., Nawijn, L., Frijling, J. L., Veltman, D. J., & Olff, M. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.11.018 · Cited by 123 · see citing works
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Kim, S., Soeken, T. A., CROMER, S. J., Martinez, S. R., Hardy, L. R., & Strathearn, L. (2013) · Brain Research · doi:10.1016/j.brainres.2013.11.009 · Cited by 121 · see citing works
Flanagan, J. C., Sippel, L. M., Wahlquist, A., Moran-Santa Maria, M. M., & Back, S. E. (2018) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2017.12.014 · Cited by 117 · see citing works
Oxytocin and stress-related disorders: neurobiological mechanisms and treatment opportunities
Sippel, L. M., Allington, C. E., Pietrzak, R. H., Harpaz-Rotem, I., Mayes, L. C., & Olff, M. (2017) · Chronic Stress · doi:10.1177/2470547016687996 · Cited by 99 · see citing works
Intrapartum Synthetic Oxytocin and Its Effects on Maternal Well‐Being at 2 Months Postpartum
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Raut, S. B., Marathe, P. A., van Eijk, L., Eri, R. D., Ravindran, M., Benedek, D. M., Ursano, R. J., Canales, J. J., & Johnson, L. R. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2022.108195 · Cited by 71 · see citing works
What's Love Got to do with it: Role of oxytocin in trauma, attachment and resilience
Sharma, S. R., Gonda, X., Dome, P., & Tarazi, F. I. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107602 · Cited by 61 · see citing works
Frijling, J. L., van Zuiden, M., Koch, S. B., Nawijn, L., Goslings, J. C., Luitse, J. S., Biesheuvel, T. H., Honig, A., Bakker, F. C., Denys, D., et al. (2014) · BMC Psychiatry · doi:10.1186/1471-244x-14-92 · Cited by 59 · see citing works
Nawijn, L., van Zuiden, M., Koch, S. B. J., Frijling, J. L., Veltman, D. J., & Olff, M. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.01.020 · Cited by 59 · see citing works
Sack, M., Spieler, D., Wizelman, L., Epple, G., Stich, J., Zaba, M., & Schmidt, U. (2017) · BMC Medicine · doi:10.1186/s12916-017-0801-0 · Cited by 57 · see citing works
Lucas-Thompson, R. G., & Holman, E. A. (2013) · Hormones and Behavior · doi:10.1016/j.yhbeh.2013.02.015 · Cited by 51 · see citing works
“…may have therapeutic value for treating PTSD (Olff et al., 2010; Pitman et al., 1993), and there is evidence that administration of oxytocin reduces acute PTSD symptoms, at least to some extent (Yatzkar and Klein, 2010), supporting the idea that the OXT is related to post-traumatic stress symptoms.”
BackgroundOxytocin improves compassion toward women among patients with PTSD
Palgi, S., Klein, E., & Shamay‐Tsoory, S. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.11.008 · Cited by 42 · see citing works
Self-citationThe role of oxytocin in empathy in PTSD.
Palgi, S., Klein, E., & Shamay‐Tsoory, S. (2016) · Psychological Trauma Theory Research Practice and Policy · doi:10.1037/tra0000142 · Cited by 37 · see citing works
Self-citationStojek, M. M., McSweeney, L. B., & Rauch, S. A. M. (2018) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2018.00281 · Cited by 36 · see citing works
Wise, A. E., & Delahanty, D. (2017) · Frontiers in Psychology · doi:10.3389/fpsyg.2017.01412 · Cited by 29 · see citing works
“Further, oxytocin administration has also been associated with improved mood and increased wish for social interactions compared to a placebo condition (Yatzkar and Klein, 2010).”
BackgroundProspects for the Pharmacological Prevention of Post-Traumatic Stress in Vulnerable Individuals
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Oxytocin affects spontaneous neural oscillations in trauma-exposed war veterans
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“Studies have also shown that OT administration improved symptom severity (Yatzkar and Klein, 2010) and reduced the physiological response to combat imagery (Pitman et al., 1993) in PTSD.”
BackgroundOxytocin for learning calm and safety
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“By modulating the activity of these brain regions and networks, oxytocin can assist with fear regulation and reward processing (Harari-Dahan & Bernstein, 2014) by enhancing motivational salience and increasing the desire for social interaction (Yatzkar & Klein, 2010).”
BackgroundMaslahati, T., Wingenfeld, K., Hellmann‐Regen, J., Kraft, J., Lyu, J., Keinert, M., Voß, A. L., Cho, A. B., Ripke, S., Otte, C., et al. (2023) · Translational Psychiatry · doi:10.1038/s41398-023-02339-z · Cited by 9 · see citing works
Emerging therapeutic landscape on delivery of oxytocin to brain for treating neurological disorders
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Advances in the pharmacotherapeutic management of post-traumatic stress disorder
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Kreutzmann, J. C., & Fendt, M. (2021) · Neurobiology of Stress · doi:10.1016/j.ynstr.2021.100313 · Cited by 6 · see citing works
Jenkins, M. A., Tedeschi, P. J., Olmert, M. D., Yount, R. A., Parish-Plass, N., & Leslie, A. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-22346-4.15010-3 · Cited by 1 · see citing works
Treating Human Trauma With the Help of Animals
Tedeschi, P. J., Jenkins, M. A., Parish-Plass, N., Olmert, M. D., & Yount, R. A. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-815395-6.00024-9 · Cited by 1 · see citing works
Zarei, S. A., Tomaz, C. A. B., de Vasconcelos, C. A. C., Tavares, M. C. H., & Sarani, M. (2020) · International Journal for Innovation Education and Research · doi:10.31686/ijier.vol8.iss8.2528
- Authors
- Yatzkar, U., & Klein, E.
- Venue
- European Neuropsychopharmacology
- Publisher
- Elsevier BV
- Published
- 2010-03
- Volume
- 20
- Pages
- S84
- ISSN
- 0924-977X (ISSN-L)
- OpenAlex
- W1973738752
- Cited by
- 32
- References
- 0
- Citations by year
- 2024: 2 · 2023: 2 · 2022: 1 · 2021: 2 · 2020: 2 · 2019: 3 · 2018: 2 · 2017: 4 · 2016: 2 · 2015: 3 · 2014: 2 · 2013: 4 · 2012: 2
- FWCI
- 2.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Neuropsychopharmacology (publishedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- intranasal oxytocin, post-traumatic stress disorder, PTSD Checklist, practice effects, Hawthorne effect, minimization, war injuries, sexual assault
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