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Cited by 51Neuroendocrine regulation and behaviorPosttraumatic Stress Disorder ResearchStress Responses and Cortisol

Environmental stress, oxytocin receptor gene (OXTR) polymorphism, and mental health following collective stress

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Lucas-Thompson, Rachel G., Holman, E. Alison·2013·Hormones and Behavior
DOI 10.1016/j.yhbeh.2013.02.015
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Abstract

We examined whether the oxytocin receptor gene (OXTR) single nucleotide polymorphism (SNP) rs53576 genotype buffers the combined impact of negative social environments (e.g., interpersonal conflict/constraint) and economic stress on post-traumatic stress (PTS) symptoms and impaired daily functioning following collective stress (September 11th terrorist attacks). Saliva was collected by mail and used to genotype 704 respondents. Participants completed Web-based assessments of pre-9/11 mental health, acute stress 9-23 days after 9/11, the quality of social environments 1 year post-9/11, economic stress 18 months post-9/11, and PTS symptoms and impaired functioning 2 and 3 years post-9/11. Interactions between negative social environments and economic stress were examined separately based on OXTR rs53576 genotype (GG vs. any A allele). For individuals with an A allele, a negative social environment significantly increased PTS symptoms without regard to the level of economic stress experienced. However, for respondents with a GG genotype, negative social environments predicted elevated PTS symptoms only for those also experiencing high economic stress. Gender moderated associations between negative social environments, economic stress, and impaired functioning. The functioning of females was most affected by negative social environments regardless of genotype and economic stress, whereas the functioning of males was differentially susceptible to economic stress depending on OXTR genotype and negative social environments. These findings suggest that it is important to consider the combined impact of gender and ongoing stress in different domains as moderators of genetic vulnerability following collective stress.

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Authors
Lucas-Thompson, R. G., & Holman, E. A.
Affiliations
University of California, Irvine (US)
ORCID
Holman, E. Alison
Venue
Hormones and Behavior
Publisher
Elsevier BV
Published
2013-04
Volume
63
Issue
4
Pages
615-624
ISSN
0018-506X (ISSN-L)
DOI
10.1016/j.yhbeh.2013.02.015
OpenAlex
W2064333626
Cited by
51
References
89
Citations by year
2026: 1 · 2025: 1 · 2024: 6 · 2023: 3 · 2022: 6 · 2021: 6 · 2020: 2 · 2019: 3 · 2018: 5 · 2017: 5 · 2016: 2 · 2015: 7 · 2014: 2 · 2013: 2
FWCI
6.49
Type
journal article
Language
en
Open access
Licence
Locations
  • Hormones and Behavior (publishedVersion)
  • PubMed (publishedVersion)
  • eScholarship (California Digital Library) (submittedVersion, cc-by)
Funders
  • Josiah Macy Jr. Foundation (SF03-09)
  • UC Irvine School of Medicine's Committee on Research and Graduate Academic Programs
  • Robert Wood Johnson Foundation (#68046)
  • National Science Foundation (BCS-9910223, BCS-0211039, BCS-0215937)
Topics
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
  • Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords
oxytocin receptor gene, OXTR rs53576, single nucleotide polymorphisms, genetic buffering, collective stress, posttraumatic stress symptoms, financial stress, interpersonal conflict, social environment, gender differences, daily functioning, genetic susceptibility, saliva genotyping
MeSH terms
Adult, Alleles, Economics, Female, Genotype, Health Status, Humans, Longitudinal Studies, Male, Mental Health, Polymorphism, Genetic, Sex Characteristics, Social Behavior, Social Environment, Stress Disorders, Post-Traumatic, Stress, Psychological, Work, Receptors, Oxytocin, Polymorphism, Single Nucleotide, Terrorism

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