Cited by 896Alzheimer's disease research and treatmentsRedox biology and oxidative stressDementia and Cognitive Impairment Research

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Oxidative stress in Alzheimer’s disease

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Smith, Mark A., Rottkamp, Catherine A., Nunomura, Akihiko, Raina, Arun K., Perry, George·2000·Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

DOI 10.1016/s0925-4439(00)00040-5

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Abstract

Oxidative balance is emerging as an important issue in understanding the pathogenesis of Alzheimer's disease. Examination of Alzheimer's disease brain has demonstrated a great deal of oxidative damage, associated with both hallmark pathologies (senile plaques and neurofibrillary tangles) as well as in normal appearing pyramidal neurons. While this suggests that oxidative stress is a proximal event in Alzheimer's disease pathogenesis, the mechanisms by which redox balance is altered in the disease remains elusive. Determining which of the proposed sources of free radicals, which include mitochondrial dysfunction, amyloid-beta-mediated processes, transition metal accumulation and genetic factors like apolipoprotein E and presenilins, is responsible for redox imbalance will lead to a better understanding of Alzheimer's disease pathogenesis and novel therapeutic approaches.

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Authors: Smith, M. A., Rottkamp, C. A., Nunomura, A., Raina, A. K., & Perry, G.
Affiliations: Case Western Reserve University (US)
Asahikawa Medical College Hospital (JP)
Corresponding author: Smith, Mark A.
ORCID: Smith, Mark A.
Rottkamp, Catherine A.
Nunomura, Akihiko
Perry, George
Venue: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Publisher: Elsevier BV
Published: 2000-07
Volume: 1502
Issue: 1
Pages: 139-144
ISSN: 0925-4439 (ISSN-L)
DOI: 10.1016/s0925-4439(00)00040-5
OpenAlex: W1983789627
Cited by: 895
References: 52
Citations by year: 2026: 13 · 2025: 22 · 2024: 30 · 2023: 33 · 2022: 31 · 2021: 38 · 2020: 36 · 2019: 40 · 2018: 37 · 2017: 26 · 2016: 33 · 2015: 34 · 2014: 32 · 2013: 39 · 2012: 39
FWCI: 5.89
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 4765 d)
Locations: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (publishedVersion)
PubMed (publishedVersion)
Biochimica et Biophysica Acta
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords: oxidative stress, Alzheimer's disease, redox imbalance, free radicals, mitochondrial dysfunction, amyloid-beta, apolipoprotein E, presenilin, amyloid plaques, neurofibrillary tangles, pyramidal neurons, pathogenesis
MeSH terms: Alzheimer Disease, Antioxidants, Free Radicals, Humans, Neurons, Oxidation-Reduction, Peptide Fragments, Amyloid beta-Peptides, Neurofibrillary Tangles, Oxidative Stress, Plaque, Amyloid

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