Oxidative stress in Alzheimer’s disease

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

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beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity

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Iron accumulation in Alzheimer disease is a source of redox-generated free radicals

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Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer disease.

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Widespread Peroxynitrite-Mediated Damage in Alzheimer’s Disease

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Oxidative DNA damage: mechanisms, mutation, and disease

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Copper toxicity, oxidative stress, and antioxidant nutrients

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Long-Term Potentiation and Memory

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Oxidative Damage Is the Earliest Event in Alzheimer Disease

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Review on in vivo and in vitro methods evaluation of antioxidant activity

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Clearance systems in the brain—implications for Alzheimer disease

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Oxidative DNA damage and disease: induction, repair and significance

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Trace elements in human physiology and pathology: zinc and metallothioneins

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Curcumin has potent anti‐amyloidogenic effects for Alzheimer's β‐amyloid fibrils in vitro

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Antioxidants and Prevention of Chronic Disease

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Oxidative stress and Alzheimer disease

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Nrf2 and Oxidative Stress: A General Overview of Mechanisms and Implications in Human Disease

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A review of the antioxidant potential of medicinal plant species

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Age-related myelin breakdown: a developmental model of cognitive decline and Alzheimer’s disease

Bartzokis, G. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2003.03.001 · Cited by 968

Plant phenolic antioxidant and prooxidant activities: phenolics-induced oxidative damage mediated by metals in plants

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Synaptic alterations in CA1 in mild Alzheimer disease and mild cognitive impairment

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Copper: toxicological relevance and mechanisms

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Involvement of oxidative stress in Alzheimer disease

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Oxidative stress hypothesis in Alzheimer’s disease: a reappraisal

Praticò, D. (2008) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2008.09.001 · Cited by 606

Oxidative stress, cell cycle, and neurodegeneration

Klein, J. A., & Ackerman, S. L. (2003) · Journal of Clinical Investigation · doi:10.1172/jci18182 · Cited by 584

Neuropathology and Pathogenesis of Encephalitis following Amyloid β Immunization in Alzheimer's Disease

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Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases

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Intracellular Coenzymes as Natural Biomarkers for Metabolic Activities and Mitochondrial Anomalies

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Indian medicinal herbs as sources of antioxidants

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Increased oxidative damage in nuclear and mitochondrial DNA in Alzheimer's disease

Wang, J., Xiong, S., Xie, C., Markesbery, W. R., & Lovell, M. A. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03053.x · Cited by 452

REVIEW: Curcumin and Alzheimer’s disease

Hamaguchi, T., Ono, K., & Yamada, M. (2010) · CNS Neuroscience & Therapeutics · doi:10.1111/j.1755-5949.2010.00147.x · Cited by 450

Proteins as biomarkers of oxidative/nitrosative stress in diseases: The contribution of redox proteomics

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Alzheimer's disease and oxidative stress: implications for novel therapeutic approaches

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Mice with Mitochondrial Complex I Deficiency Develop a Fatal Encephalomyopathy

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Brain protein oxidation in age-related neurodegenerative disorders that are associated with aggregated proteins

Butterfield, D. A., & Kański, J. (2001) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(01)00249-4 · Cited by 420

Oxidative stress, mitochondrial dysfunction and cellular stress response in Friedreich's ataxia

Calabrese, V., Lodi, R., Tonon, C., D’Agata, V., Sapienza, M. A., Scapagnini, G., Mangiameli, A., Pennisi, G., Stella, A. M. G., & Butterfield, D. A. (2005) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2005.03.012 · Cited by 411

In vitro models for antioxidant activity evaluation and some medicinal plants possessing antioxidant properties: An overview

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Food-Derived Bioactive Peptides on Inflammation and Oxidative Stress

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Melatonin, human aging, and age-related diseases

Karasek, M. (2004) · Experimental Gerontology · doi:10.1016/j.exger.2004.04.012 · Cited by 380

The role of oxidative stress in the toxicity induced by amyloid β-peptide in Alzheimer’s disease

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Role of mitochondrial dysfunction in Alzheimer's disease

Castellani, R. J., Hirai, K., Aliev, G. M., Drew, K. L., Nunomura, A., Takeda, A., Cash, A., Obrenovich, M. E., Perry, G. L., & Smith, M. A. (2002) · Journal of Neuroscience Research · doi:10.1002/jnr.10389 · Cited by 366

Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson’s, Huntington’s, Alzheimer’s, prions, bactericides, chemical toxicology and others as examples

Kell, D. B. (2010) · Archives of Toxicology · doi:10.1007/s00204-010-0577-x · Cited by 361

Metals and amyloid‐β in Alzheimer's disease

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Overexpression of Alzheimer's Disease Amyloid-β Opposes the Age-dependent Elevations of Brain Copper and Iron

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Insulin resistance and amyloidogenesis as common molecular foundation for type 2 diabetes and Alzheimer's disease

Zhao, W.-Q., & Townsend, M. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2008.10.014 · Cited by 291

Vitamin E and Cognitive Decline in Older Persons

Morris, M. C., Evans, D. A., Bienias, J. L., Tangney, C. C., & Wilson, R. S. (2002) · Archives of Neurology · doi:10.1001/archneur.59.7.1125 · Cited by 346

Oxidative stress in Alzheimer's disease

Chauhan, V. P. S., & Chauhan, A. (2006) · Pathophysiology · doi:10.1016/j.pathophys.2006.05.004 · Cited by 349

Molecular indices of oxidative stress and mitochondrial dysfunction occur early and often progress with severity of Alzheimer's disease

de la Monte, S. M., & Wands, J. R. (2006) · Journal of Alzheimer s Disease · doi:10.3233/jad-2006-9209 · Cited by 324

Iron (III) induces aggregation of hyperphosphorylated τ and its reduction to iron (II) reverses the aggregation: implications in the formation of neurofibrillary tangles of Alzheimer's disease

Yamamoto, A., Shin, R., Hasegawa, K., Naiki, H., Sato, H., Yoshimasu, F., & Kitamoto, T. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.t01-1-01061.x · Cited by 313

Mitochondrial dysfunction, apoptotic cell death, and Alzheimer’s disease

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Antioxidant Capacity Determination in Plants and Plant‐Derived Products: A Review

Pisoschi, A. M., Pop, A., Cimpeanu, C. L., & Predoi, G. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/9130976 · Cited by 329

Early Vitamin E supplementation in young but not aged mice reduces Aβ levels and amyloid deposition in a transgenic model of Alzheimer's disease

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Alzheimer disease, the two-hit hypothesis: An update

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Amyloid β-induced Changes in Nitric Oxide Production and Mitochondrial Activity Lead to Apoptosis

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Dietary protein oxidation: A silent threat to human health?

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Alzheimer’s disease-related alterations in synaptic density: neocortex and hippocampus.

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Hypoxia-inducible Factor Prolyl 4-Hydroxylase Inhibition

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Intracellular Aβ42 activates p53 promoter: a pathway to neurodegeneration in Alzheimer's disease

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Parallel findings in age-related macular degeneration and Alzheimer’s disease

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High dietary fat induces NADPH oxidase-associated oxidative stress and inflammation in rat cerebral cortex

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Ferulic acid ethyl ester protects neurons against amyloid β‐ peptide(1–42)‐induced oxidative stress and neurotoxicity: relationship to antioxidant activity

Rukhsana Sultana, A., Ravagna, A., Abdul, H. M., Calabrese, V., & Butterfield, D. A. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02899.x · Cited by 276

Oxidative stress in alzheimer’s disease: A review on emergent natural polyphenolic therapeutics

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Lipid peroxidation is an early event in the brain in amnestic mild cognitive impairment

Markesbery, W. R., Kryscio, R. J., Lovell, M. A., & Morrow, J. D. (2005) · Annals of Neurology · doi:10.1002/ana.20629 · Cited by 277

Bioactive metabolites from macrofungi: ethnopharmacology, biological activities and chemistry

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Homocysteine potentiates β‐amyloid neurotoxicity: role of oxidative stress

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Neurobiology of Alzheimer′s disease

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Anti-amyloidogenic activity of tannic acid and its activity to destabilize Alzheimer's β-amyloid fibrils in vitro

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Oxidative DNA damage in peripheral leukocytes of mild cognitive impairment and AD patients

Migliore, L., Fontana, I., Trippi, F., Colognato, R., Coppedè, F., Tognoni, G., Nucciarone, B., & Siciliano, G. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.07.016 · Cited by 266

Maculas Affected by Age-Related Macular Degeneration Contain Increased Chelatable Iron in the Retinal Pigment Epithelium and Bruch's Membrane

Hahn, P. (2003) · Archives of Ophthalmology · doi:10.1001/archopht.121.8.1099 · Cited by 258

Vascular dysfunction in the pathogenesis of Alzheimer's disease — A review of endothelium-mediated mechanisms and ensuing vicious circles

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Prion Protein Accumulation and Neuroprotection in Hypoxic Brain Damage

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Carbonylation of Adipose Proteins in Obesity and Insulin Resistance

Grimsrud, P. A., Picklo, M. J., Griffin, T. J., & Bernlohr, D. (2007) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m600120-mcp200 · Cited by 249

Iron (III) induces aggregation of hyperphosphorylated τ and its reduction to iron (II) reverses the aggregation: implications in the formation of neurofibrillary tangles of Alzheimer's disease

Yamamoto, A., Shin, R., Hasegawa, K., Naiki, H., Sato, H., YOSHIMASU, F., & Kitamoto, T. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.01061.x · Cited by 245

Caspase-9 Activation and Caspase Cleavage of tau in the Alzheimer's Disease Brain

Rohn, T. T., Rissman, R. A., Davis, M. C., Kim, Y., Cotman, C. W., & Head, E. (2002) · Neurobiology of Disease · doi:10.1006/nbdi.2002.0549 · Cited by 248

Emerging Roles of Anacardic Acid and Its Derivatives: A Pharmacological Overview

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Elevation of serum copper levels in Alzheimer’s disease

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Downregulation of CREB expression in Alzheimer's brain and in Aβ-treated rat hippocampal neurons

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Qualitative and Quantitative Determination of Phytochemical Contents of Indigenous Nigerian Softwoods

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Functional foods, herbs and nutraceuticals: towards biochemical mechanisms of healthy aging

Ferrari, C. K. B. (2004) · Biogerontology · doi:10.1007/s10522-004-2566-z · Cited by 227

Does measurement of oxidative damage to DNA have clinical significance?

Cooke, M. S., Oliński, R., & Evans, M. D. (2005) · Clinica Chimica Acta · doi:10.1016/j.cca.2005.09.009 · Cited by 225

Melatonin in Alzheimer's disease and other neurodegenerative disorders

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Peroxynitrite Mediates Neurotoxicity of Amyloid β-Peptide 1–42 - and Lipopolysaccharide-Activated Microglia

Xie, Z., Wei, M., Morgan, T. E., Fabrizio, P., Han, D., Finch, C. E., & Longo, V. D. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-09-03484.2002 · Cited by 272

Nitration of Tau Protein Is Linked to Neurodegeneration in Tauopathies

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Amyloid‐fibril formation

Žerovnik, E. (2002) · European Journal of Biochemistry · doi:10.1046/j.1432-1033.2002.03024.x · Cited by 220

Vitamin D cell signalling in health and disease

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Emerging PET Radiotracers and Targets for Imaging of Neuroinflammation in Neurodegenerative Diseases: Outlook Beyond TSPO

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Biochemical pharmacology of functional foods and prevention of chronic diseases of aging

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Immunohistochemical analysis of human brain suggests pathological synergism of Alzheimer's disease and diabetes mellitus

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Berberine and neurodegeneration: A review of literature

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Estrogen, neuroinflammation and neuroprotection in Parkinson’s disease: Glia dictates resistance versus vulnerability to neurodegeneration

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Aging, oxidative stress and degenerative diseases: mechanisms, complications and emerging therapeutic strategies

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Oxidized cholesterol as the driving force behind the development of Alzheimer’s disease

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Antioxidative enzymes and increased oxidative stress in depressive women

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