Cited by 177Developmental Biology and Gene RegulationPancreatic function and diabetesLiver physiology and pathology

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Prox1 is an early specific marker for the developing liver and pancreas in the mammalian foregut endoderm

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Burke, Zoë, Oliver, Guillermo·2002·Mechanisms of Development

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Abstract

Although important progress has been made recently in the elucidation of the molecular mechanisms that regulate differentiation and morphogenesis of endoderm-derived tissues such as pancreas and liver, less is known about the preliminary steps of early regional specification. Recent evidence supports the proposal that the early endoderm contains a bipotential precursor cell type for pancreas and liver. We have also previously shown that the activity of the homeobox gene Prox1 controls hepatocyte migration during liver morphogenesis. Using detailed comparative analysis of whole embryos and reverse transcriptase polymerase chain reaction of dissected embryonic endoderm, we have now determined that in the early endoderm, Prox1 expression is restricted to regions giving rise to the mammalian pancreas and liver. This finding indicates that Prox1 is one of the earliest specific markers of this commonly fated region of the mammalian endoderm.

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Additional file 7 of Dysregulated lncRNAs regulate human umbilical cord mesenchymal stem cell differentiation into insulin-producing cells by forming a regulatory network with mRNAs
Xie, T., Huang, Q., Huang, Q., Huang, Y., Liu, S., Zeng, H., & Liu, J. (2024) · Figshare · doi:10.6084/m9.figshare.26672772
Additional file 4 of Dysregulated lncRNAs regulate human umbilical cord mesenchymal stem cell differentiation into insulin-producing cells by forming a regulatory network with mRNAs
Xie, T., Huang, Q., Huang, Q., Huang, Y., Liu, S., Zeng, H., & Liu, J. (2024) · Figshare · doi:10.6084/m9.figshare.26672763
Additional file 8 of Dysregulated lncRNAs regulate human umbilical cord mesenchymal stem cell differentiation into insulin-producing cells by forming a regulatory network with mRNAs
Xie, T., Huang, Q., Huang, Q., Huang, Y., Liu, S., Zeng, H., & Liu, J. (2024) · Figshare · doi:10.6084/m9.figshare.26672775
Additional file 3 of Dysregulated lncRNAs regulate human umbilical cord mesenchymal stem cell differentiation into insulin-producing cells by forming a regulatory network with mRNAs
Xie, T., Huang, Q., Huang, Q., Huang, Y., Liu, S., Zeng, H., & Liu, J. (2024) · Figshare · doi:10.6084/m9.figshare.26672760
Additional file 6 of Dysregulated lncRNAs regulate human umbilical cord mesenchymal stem cell differentiation into insulin-producing cells by forming a regulatory network with mRNAs
Xie, T., Huang, Q., Huang, Q., Huang, Y., Liu, S., Zeng, H., & Liu, J. (2024) · Figshare · doi:10.6084/m9.figshare.26672769
Additional file 2 of Dysregulated lncRNAs regulate human umbilical cord mesenchymal stem cell differentiation into insulin-producing cells by forming a regulatory network with mRNAs
Xie, T., Huang, Q., Huang, Q., Huang, Y., Liu, S., Zeng, H., & Liu, J. (2024) · Figshare · doi:10.6084/m9.figshare.26672757
Additional file 5 of Dysregulated lncRNAs regulate human umbilical cord mesenchymal stem cell differentiation into insulin-producing cells by forming a regulatory network with mRNAs
Xie, T., Huang, Q., Huang, Q., Huang, Y., Liu, S., Zeng, H., & Liu, J. (2024) · Figshare · doi:10.6084/m9.figshare.26672766
Additional file 1 of Dysregulated lncRNAs regulate human umbilical cord mesenchymal stem cell differentiation into insulin-producing cells by forming a regulatory network with mRNAs
Xie, T., Huang, Q., Huang, Q., Huang, Y., Liu, S., Zeng, H., & Liu, J. (2024) · Figshare · doi:10.6084/m9.figshare.26672754
Additional file 9 of Dysregulated lncRNAs regulate human umbilical cord mesenchymal stem cell differentiation into insulin-producing cells by forming a regulatory network with mRNAs
Xie, T., Huang, Q., Huang, Q., Huang, Y., Liu, S., Zeng, H., & Liu, J. (2024) · Figshare · doi:10.6084/m9.figshare.26672778
Additional file 10 of Dysregulated lncRNAs regulate human umbilical cord mesenchymal stem cell differentiation into insulin-producing cells by forming a regulatory network with mRNAs
Xie, T., Huang, Q., Huang, Q., Huang, Y., Liu, S., Zeng, H., & Liu, J. (2024) · Figshare · doi:10.6084/m9.figshare.26672781

Authors: Burke, Z., & Oliver, G.
Affiliations: St. Jude Children's Research Hospital (US)
Corresponding author: Oliver, Guillermo
ORCID: Burke, Zoë
Oliver, Guillermo
Venue: Mechanisms of Development
Publisher: Elsevier BV
Published: 2002-10
Volume: 118
Issue: 1-2
Pages: 147-155
ISSN: 0925-4773 (ISSN-L)
DOI: 10.1016/s0925-4773(02)00240-x
OpenAlex: W2082073317
Cited by: 177
References: 23
Citations by year: 2026: 1 · 2025: 6 · 2024: 14 · 2023: 10 · 2022: 11 · 2021: 5 · 2020: 7 · 2019: 7 · 2018: 7 · 2017: 8 · 2016: 5 · 2015: 3 · 2014: 7 · 2013: 7 · 2012: 8
FWCI: 1.86
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 3942 d)
Locations: Mechanisms of Development (publishedVersion)
PubMed (publishedVersion)
Funders: American Lebanese Syrian Associated Charities (CA 21765)
National Institutes of Health (CA21765))
National Eye Institute (R01EY012162, EY 12162)
National Cancer Institute (CA21765, P30CA021765)
National Institute of General Medical Sciences (GM58462, R01GM058462)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
Health Sciences › Medicine › Hepatology › Liver physiology and pathology
Keywords: Prox1, homeobox genes, foregut endoderm, liver development, pancreatic development, regional specification, hepatocyte migration, embryonic endoderm, developmental markers
MeSH terms: Prospero-Related Homeobox 1 Protein, Animals, beta-Galactosidase, Cell Movement, Cell Separation, DNA-Binding Proteins, Endoderm, Flow Cytometry, Immunohistochemistry, Liver, Notochord, Nuclear Proteins, Pancreas, Time Factors, Transcription Factors, Trans-Activators, Protein Serine-Threonine Kinases, In Situ Hybridization, Receptors, Growth Factor, Homeodomain Proteins, Gene Expression Regulation, Developmental, Reverse Transcriptase Polymerase Chain Reaction, Hepatocytes, Tumor Suppressor Proteins, Activin Receptors, Type I, Mice, Hepatocyte Nuclear Factor 3-beta, Hepatocyte Nuclear Factor 6, Bone Morphogenetic Protein Receptors, Type I, Hedgehog Proteins

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Prox1 is an early specific marker for the developing liver and pancreas in the mammalian foregut endoderm

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