Hepatocyte migration during liver development requires Prox1
Abstract
Several genes are required during the early phases of liver specification, proliferation and differentiation. Here we report that Prox1 is required for hepatocyte migration. Loss of Prox1 leads to formation of a smaller liver with a reduced population of clustered hepatocytes surrounded by a laminin-rich basal membrane.
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PROX1 is essential for hepatocyte commitment.
“PROX1, essential for hepatocyte commitment59–61, meets our safeguard repressor criteria.”
From Active repression of cell fate plasticity by PROX1 safeguards hepatocyte identity and prevents liver tumorigenesis (2025) · cites this paper as [61]
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A Stepwise Model of the Development of Lymphatic Vasculature
Oliver, G. C., & Harvey, N. L. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb04876.x · Cited by 71 · see citing works
Self-citationAn HDAC3-PROX1 corepressor module acts on HNF4α to control hepatic triglycerides
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Expression and prognostic value of transcription factor PROX1 in colorectal cancer
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- Authors
- Sosa-Pineda, B., Wigle, J. T., & Oliver, G.
- Affiliations
- St. Jude Children's Research Hospital (US)
- Corresponding author
- Oliver, Guillermo
- Venue
- Nature Genetics
- Published
- 2000-07
- Volume
- 25
- Issue
- 3
- Pages
- 254-255
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- OpenAlex
- W1488041855
- Cited by
- 381
- References
- 11
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 6 · 2023: 20 · 2022: 14 · 2021: 15 · 2020: 15 · 2019: 15 · 2018: 14 · 2017: 16 · 2016: 22 · 2015: 11 · 2014: 14 · 2013: 12 · 2012: 20
- FWCI
- 7.07
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Genetics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Eye Institute (R01EY012162, EY 12162)
- National Institute of General Medical Sciences (GM58462, R01GM058462)
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Keywords
- Prox1, hepatocyte migration, liver development, hepatocyte differentiation
- MeSH terms
- Prospero-Related Homeobox 1 Protein, Animals, Cell Movement, Liver, Homeodomain Proteins, Tumor Suppressor Proteins, Mice
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