Cited by 381Liver physiology and pathologyDevelopmental Biology and Gene RegulationCongenital heart defects research

Hepatocyte migration during liver development requires Prox1

Sosa-Pineda, Beatriz, Wigle, Jeffrey T., Oliver, Guillermo·2000·Nature Genetics

Abstract

Several genes are required during the early phases of liver specification, proliferation and differentiation. Here we report that Prox1 is required for hepatocyte migration. Loss of Prox1 leads to formation of a smaller liver with a reduced population of clustered hepatocytes surrounded by a laminin-rich basal membrane.

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Crossref · 10.1038/76996

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11 of 11 references verified0 citation errors · 0 not checkable

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Authors
Sosa-Pineda, B., Wigle, J. T., & Oliver, G.
Affiliations
St. Jude Children's Research Hospital (US)
Corresponding author
Oliver, Guillermo
Venue
Nature Genetics
Published
2000-07
Volume
25
Issue
3
Pages
254-255
ISSN
  • 1061-4036 (ISSN-L)
  • 1546-1718
OpenAlex
W1488041855
Cited by
381
References
11
Citations by year
2026: 3 · 2025: 9 · 2024: 6 · 2023: 20 · 2022: 14 · 2021: 15 · 2020: 15 · 2019: 15 · 2018: 14 · 2017: 16 · 2016: 22 · 2015: 11 · 2014: 14 · 2013: 12 · 2012: 20
FWCI
7.07
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Genetics (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Eye Institute (R01EY012162, EY 12162)
  • National Institute of General Medical Sciences (GM58462, R01GM058462)
Topics
  • Health Sciences › Medicine › Hepatology › Liver physiology and pathology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
Keywords
Prox1, hepatocyte migration, liver development, hepatocyte differentiation
MeSH terms
Prospero-Related Homeobox 1 Protein, Animals, Cell Movement, Liver, Homeodomain Proteins, Tumor Suppressor Proteins, Mice

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