Initiation of Mammalian Liver Development from Endoderm by Fibroblast Growth Factors
Abstract
The signaling molecules that elicit embryonic induction of the liver from the mammalian gut endoderm or induction of other gut-derived organs are unknown. Close proximity of cardiac mesoderm, which expresses fibroblast growth factors (FGFs) 1, 2, and 8, causes the foregut endoderm to develop into the liver. Treatment of isolated foregut endoderm from mouse embryos with FGF1 or FGF2, but not FGF8, was sufficient to replace cardiac mesoderm as an inducer of the liver gene expression program, the latter being the first step of hepatogenesis. The hepatogenic response was restricted to endoderm tissue, which selectively coexpresses FGF receptors 1 and 4. Further studies with FGFs and their specific inhibitors showed that FGF8 contributes to the morphogenetic outgrowth of the hepatic endoderm. Thus, different FGF signals appear to initiate distinct phases of liver development during mammalian organogenesis.
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Endoderm patterning is controlled by soluble factors provided by an adjacent germ layer.
“Studies of ventral foregut patterning suggest that endoderm patterning is controlled by soluble factors provided by an adjacent germ layer [12].”
From A systematic screen for genes expressed in definitive endoderm by Serial Analysis of Gene Expression (SAGE) (2007) · cites this paper as [12]
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- Authors
- Jung, J., Zheng, M., Goldfarb, M., & Zaret, K. S.
- Affiliations
- Brown University (US)
- Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Box G-J363, Providence, RI 02912, USA.
- Icahn School of Medicine at Mount Sinai (US)
- Corresponding author
- Zaret, Kenneth S.
- Venue
- Science
- Published
- 1999-06-18
- Volume
- 284
- Issue
- 5422
- Pages
- 1998-2003
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2033791639
- Cited by
- 721
- References
- 0
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 7 · 2023: 18 · 2022: 8 · 2021: 10 · 2020: 22 · 2019: 22 · 2018: 19 · 2017: 19 · 2016: 27 · 2015: 17 · 2014: 25 · 2013: 34 · 2012: 42
- FWCI
- 16.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of General Medical Sciences (GM 36477)
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fibroblast Growth Factor Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- liver development, hepatogenesis, fibroblast growth factor, FGF1, FGF2, FGF8, foregut endoderm, cardiac mesoderm, embryonic induction, fibroblast growth factor receptor, organogenesis, mouse embryo
- MeSH terms
- alpha-Fetoproteins, Animals, Digestive System, Embryonic Induction, Endoderm, Fibroblast Growth Factors, Heart, Heparan Sulfate, Liver, Mesoderm, Mice, Inbred C3H, Morphogenesis, Organ Specificity, Prealbumin, Recombinant Fusion Proteins, Serum Albumin, Signal Transduction, Gene Expression, Fibroblast Growth Factor 1, Fibroblast Growth Factor 2, Receptors, Fibroblast Growth Factor, Culture Techniques, Mice, Fibroblast Growth Factor 8
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