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Prox1 is an early specific marker for the developing liver and pancreas in the mammalian foregut endoderm
Open accessAbstract
Although important progress has been made recently in the elucidation of the molecular mechanisms that regulate differentiation and morphogenesis of endoderm-derived tissues such as pancreas and liver, less is known about the preliminary steps of early regional specification. Recent evidence supports the proposal that the early endoderm contains a bipotential precursor cell type for pancreas and liver. We have also previously shown that the activity of the homeobox gene Prox1 controls hepatocyte migration during liver morphogenesis. Using detailed comparative analysis of whole embryos and reverse transcriptase polymerase chain reaction of dissected embryonic endoderm, we have now determined that in the early endoderm, Prox1 expression is restricted to regions giving rise to the mammalian pancreas and liver. This finding indicates that Prox1 is one of the earliest specific markers of this commonly fated region of the mammalian endoderm.
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“For example, Prox1 is only expressed by the liver and pancreas progenitors beginning at the 7–8 somite stage [43].”
From A systematic screen for genes expressed in definitive endoderm by Serial Analysis of Gene Expression (SAGE) (2007) · cites this paper as [43]
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Xu, C., & Zaret, K. S. (2012) · Nucleus · doi:10.4161/nucl.19321 · Cited by 18
Magnesium and Liver Metabolism Through the Lifespan
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Imaging leukocyte migration through afferent lymphatics*
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Metadata
- Authors
- Burke, Z., & Oliver, G.
- Affiliations
- St. Jude Children's Research Hospital (US)
- Corresponding author
- Oliver, Guillermo
- Venue
- Mechanisms of Development
- Publisher
- Elsevier BV
- Published
- 2002-10
- Volume
- 118
- Issue
- 1-2
- Pages
- 147-155
- ISSN
- 0925-4773 (ISSN-L)
- OpenAlex
- W2082073317
- Cited by
- 177
- References
- 23
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 14 · 2023: 10 · 2022: 11 · 2021: 5 · 2020: 7 · 2019: 7 · 2018: 7 · 2017: 8 · 2016: 5 · 2015: 3 · 2014: 7 · 2013: 7 · 2012: 8
- FWCI
- 1.86
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Mechanisms of Development (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Lebanese Syrian Associated Charities (CA 21765)
- National Institutes of Health (CA21765))
- National Eye Institute (R01EY012162, EY 12162)
- National Cancer Institute (CA21765, P30CA021765)
- National Institute of General Medical Sciences (GM58462, R01GM058462)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Keywords
- Prox1, homeobox genes, foregut endoderm, liver development, pancreatic development, regional specification, hepatocyte migration, embryonic endoderm, developmental markers
- MeSH terms
- Prospero-Related Homeobox 1 Protein, Animals, beta-Galactosidase, Cell Movement, Cell Separation, DNA-Binding Proteins, Endoderm, Flow Cytometry, Immunohistochemistry, Liver, Notochord, Nuclear Proteins, Pancreas, Time Factors, Transcription Factors, Trans-Activators, Protein Serine-Threonine Kinases, In Situ Hybridization, Receptors, Growth Factor, Homeodomain Proteins, Gene Expression Regulation, Developmental, Reverse Transcriptase Polymerase Chain Reaction, Hepatocytes, Tumor Suppressor Proteins, Activin Receptors, Type I, Mice, Hepatocyte Nuclear Factor 3-beta, Hepatocyte Nuclear Factor 6, Bone Morphogenetic Protein Receptors, Type I, Hedgehog Proteins
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