Novel pattern of Brachyury gene expression in hemichordate embryos
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Together with echinoderms and chordates, hemichordates constitute the third major group of the deuterostomes, which share a number of common developmental features. The Brachyury gene is responsible for the formation of notochord, the most defining feature of chordates. Therefore, isolation and characterization of the hemichordate homolog of Brachyury is key to understand the origin and evolution of chordates. Here we show that the hemichordate Brachyury gene (PfBra) is expressed in two regions of the gastrula and young tornaria larva, the archenteron invagination region and the stomodeum invagination region.
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Hemichordate and echinoderm dipleurula larvae both express Brachyury in the oral and anal regions of the larval gut.
“Thus both hemichordate and echinoderm dipleurula larvae express the Brachyury gene in the oral and anal regions of the larval gut.”
From Bilaterian Origins: Significance of New Experimental Observations (2000) · cites this paper as Tagawa et al., 1998
All deuterostome dipleurula larvae share significant similarities.
“The notion that significant similarities are shared by all deuterostome dipleurula larvae is further supported by new studies on Brachyury expression in enteropneust hemichordates”
From Bilaterian Origins: Significance of New Experimental Observations (2000) · cites this paper as Tagawa et al., 1998
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Bilaterian Origins: Significance of New Experimental Observations
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- Authors
- Tagawa, K., Humphreys, T., & Satoh, N.
- Affiliations
- Kyoto University (JP)
- University of Hawaiʻi at Mānoa (US)
- Corresponding author
- Satoh, Noriyuki
- Venue
- Mechanisms of Development
- Publisher
- Elsevier BV
- Published
- 1998-07
- Volume
- 75
- Issue
- 1-2
- Pages
- 139-143
- ISSN
- 0925-4773 (ISSN-L)
- OpenAlex
- W1980347984
- Cited by
- 117
- References
- 21
- Citations by year
- 2025: 6 · 2024: 2 · 2023: 1 · 2022: 5 · 2021: 2 · 2020: 1 · 2019: 2 · 2018: 1 · 2017: 1 · 2016: 3 · 2015: 5 · 2014: 3 · 2013: 3 · 2012: 5
- FWCI
- 3.72
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Mechanisms of Development (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Education, Culture, Sports, Science and Technology
- Human Frontier Science Program (RG212/1997)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Physical Sciences › Earth and Planetary Sciences › Paleontology › Marine Invertebrate Physiology and Ecology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Planarian Biology and Electrostimulation
- Keywords
- Brachyury, hemichordates, gene expression, chordate origin, gastrula, deuterostome development
- MeSH terms
- Brachyury Protein, Amino Acid Sequence, Animals, Chordata, Nonvertebrate, DNA-Binding Proteins, Embryo, Nonmammalian, Fetal Proteins, Molecular Sequence Data, Transcription Factors, Transcription, Genetic, In Situ Hybridization, Sequence Analysis, DNA, DNA, Complementary, Gene Expression Regulation, Developmental, Evolution, Molecular, T-Box Domain Proteins
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