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Dishevelled: at the crossroads of divergent intracellular signaling pathways
Open accessAbstract
During the development of multicellular organisms the formation of complex patterns relies on specific cell-cell signaling events. For tissues to become spatially organized and cells to become committed to specialized fates it is absolutely crucial for proper development that the underlying signaling systems receive and route information correctly. Recently, a wealth of genetic and biochemical experimental data has been collected about prevalent evolutionary conserved signaling families, such as the Wnts, Dpp/BMPs, and Hedgehogs, in flies, worms, and vertebrates. Paradoxically, members of a particular signaling family often have receptors with similar biochemical binding properties, though they activate different intracellular pathways in vivo and can be phenotypically distinguished. How are their specific biological responses then generated? With respect to signaling specificity in Wnt pathways, Dishevelled is an intriguing protein; in Drosophila melanogaster it is required in two distinct signaling pathways, that share Frizzled receptors of similar structure, but have distinct intracellular signaling routes. Recent results suggest that Dishevelled is a multifunctional protein at the crossroads of divergent Wnt/Fz pathways. Dishevelled appears to be a key factor in Wnt signaling to read' signals coming from the plasma membrane and route them into the correct intracellular pathways.
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“The Dsh protein, as previously mentioned has three conserved domains: DIX, PDZ and DEP domains116”
From Wnt signal transduction pathways (2008) · cites this paper as [116]
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Metadata
- Authors
- Boutros, M., & Mlodzik, M.
- Affiliations
- European Molecular Biology Laboratory (DE)
- Corresponding author
- Mlodzik, Marek
- Venue
- Mechanisms of Development
- Publisher
- Elsevier BV
- Published
- 1999-05
- Volume
- 83
- Issue
- 1-2
- Pages
- 27-37
- ISSN
- 0925-4773 (ISSN-L)
- OpenAlex
- W2084060837
- Cited by
- 275
- References
- 66
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 1 · 2023: 2 · 2022: 5 · 2021: 3 · 2020: 6 · 2019: 1 · 2018: 6 · 2017: 5 · 2016: 9 · 2015: 8 · 2014: 9 · 2013: 4 · 2012: 7
- FWCI
- 1.76
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Mechanisms of Development (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Boehringer Ingelheim Fonds
- Studienstiftung des Deutschen Volkes
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Hedgehog Signaling Pathway Studies
- Keywords
- Dishevelled, Wnt signaling, Frizzled receptors, Drosophila melanogaster, signaling specificity, intracellular signaling, Hedgehog signaling, cell-to-cell communication, developmental patterning
- MeSH terms
- Dishevelled Proteins, Amino Acid Sequence, Animals, Drosophila, Membrane Proteins, Models, Genetic, Molecular Sequence Data, Phosphoproteins, Proto-Oncogene Proteins, Xenopus, Signal Transduction, Sequence Homology, Amino Acid, Drosophila Proteins, Zebrafish Proteins, Receptors, G-Protein-Coupled, Adaptor Proteins, Signal Transducing, Wnt Proteins, Wnt1 Protein, Frizzled Receptors, Mice
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