Cited by 275Wnt/β-catenin signaling in development and cancerDevelopmental Biology and Gene RegulationHedgehog Signaling Pathway Studies

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Dishevelled: at the crossroads of divergent intracellular signaling pathways

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Boutros, Michael, Mlodzik, Marek·1999·Mechanisms of Development

DOI 10.1016/s0925-4773(99)00046-5

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Abstract

During the development of multicellular organisms the formation of complex patterns relies on specific cell-cell signaling events. For tissues to become spatially organized and cells to become committed to specialized fates it is absolutely crucial for proper development that the underlying signaling systems receive and route information correctly. Recently, a wealth of genetic and biochemical experimental data has been collected about prevalent evolutionary conserved signaling families, such as the Wnts, Dpp/BMPs, and Hedgehogs, in flies, worms, and vertebrates. Paradoxically, members of a particular signaling family often have receptors with similar biochemical binding properties, though they activate different intracellular pathways in vivo and can be phenotypically distinguished. How are their specific biological responses then generated? With respect to signaling specificity in Wnt pathways, Dishevelled is an intriguing protein; in Drosophila melanogaster it is required in two distinct signaling pathways, that share Frizzled receptors of similar structure, but have distinct intracellular signaling routes. Recent results suggest that Dishevelled is a multifunctional protein at the crossroads of divergent Wnt/Fz pathways. Dishevelled appears to be a key factor in Wnt signaling to read' signals coming from the plasma membrane and route them into the correct intracellular pathways.

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Authors: Boutros, M., & Mlodzik, M.
Affiliations: European Molecular Biology Laboratory (DE)
Corresponding author: Mlodzik, Marek
ORCID: Boutros, Michael
Mlodzik, Marek
Venue: Mechanisms of Development
Publisher: Elsevier BV
Published: 1999-05
Volume: 83
Issue: 1-2
Pages: 27-37
ISSN: 0925-4773 (ISSN-L)
DOI: 10.1016/s0925-4773(99)00046-5
OpenAlex: W2084060837
Cited by: 275
References: 66
Citations by year: 2026: 2 · 2025: 5 · 2024: 1 · 2023: 2 · 2022: 5 · 2021: 3 · 2020: 6 · 2019: 1 · 2018: 6 · 2017: 5 · 2016: 9 · 2015: 8 · 2014: 9 · 2013: 4 · 2012: 7
FWCI: 1.76
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 5191 d)
Locations: Mechanisms of Development (publishedVersion)
PubMed (publishedVersion)
Funders: Boehringer Ingelheim Fonds
Studienstiftung des Deutschen Volkes
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Hedgehog Signaling Pathway Studies
Keywords: Dishevelled, Wnt signaling, Frizzled receptors, Drosophila melanogaster, signaling specificity, intracellular signaling, Hedgehog signaling, cell-to-cell communication, developmental patterning
MeSH terms: Dishevelled Proteins, Amino Acid Sequence, Animals, Drosophila, Membrane Proteins, Models, Genetic, Molecular Sequence Data, Phosphoproteins, Proto-Oncogene Proteins, Xenopus, Signal Transduction, Sequence Homology, Amino Acid, Drosophila Proteins, Zebrafish Proteins, Receptors, G-Protein-Coupled, Adaptor Proteins, Signal Transducing, Wnt Proteins, Wnt1 Protein, Frizzled Receptors, Mice

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Dishevelled: at the crossroads of divergent intracellular signaling pathways

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