Cited by 261Neurotransmitter Receptor Influence on BehaviorMind wandering and attentionNeural and Behavioral Psychology Studies

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Increases in cortical acetylcholine release during sustained attention performance in rats

Himmelheber, Anne Marie, Sarter, Martin, Bruno, John P·2000·Cognitive Brain Research

DOI 10.1016/s0926-6410(00)00012-4

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Abstract

Acetylcholine (ACh) efflux in the frontoparietal cortex was studied with in vivo microdialysis while rats performed in an operant task designed to assess sustained attention. Transferring animals from the baseline environment into the operant chambers elicited a robust increase in cortical ACh efflux that persisted throughout the 18-min pre-task period. Subsequent performance in the 36-min sustained attention task was associated with further significant increases in frontoparietal ACh efflux, while the termination of the task resulted in a delayed decline in ACh levels. Upon the 12-min presentation of a visual distracter (flashing houselight, 0.5 Hz) during task performance, animals initially developed a significant response bias to the left lever in the first 6-min distracter block, reflecting a reduction of attentional effort. Under continued conditions of increased attentional demand, performance recovered during the second 6-min distracter block. This return to attentional processing was accompanied by an increase in cortical ACh efflux, suggesting that the augmentation of attentional demand produced by the distracter elicited further increases in ACh release. The enhancement of cortical ACh efflux observed prior to task performance implies the presence of complex relationships between cortical ACh release and anticipatory and/or contextual factors related to operant performance and attentional processing. This finding, along with the further increases in cortical ACh efflux associated with task performance, extends hypotheses regarding the crucial role of cortical cholinergic transmission for attentional functions. Furthermore, the effects of the distracter stimulus provide evidence for a direct relationship between attentional effort and cortical ACh release.

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Everitt, B. J., & Robbins, T. W. (1997) · Annual Review of Psychology · doi:10.1146/annurev.psych.48.1.649 · Cited by 1,348
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Bowen, D. M., Smith, C. B., White, P., & DAVISON, A. N. (1976) · Brain · doi:10.1093/brain/99.3.459 · Cited by 1,313
The Continuing Problem of False Positives in Repeated Measures ANOVA in Psychophysiology: A Multivariate Solution
Vasey, M. W., & Thayer, J. F. (1987) · Psychophysiology · doi:10.1111/j.1469-8986.1987.tb00324.x · Cited by 1,063
Cholinergic systems in mammalian brain and spinal cord
WOOLF, N. (1991) · Progress in Neurobiology · doi:10.1016/0301-0082(91)90006-m · Cited by 948
Neurotransmitter enzyme abnormalities in senile dementia
Perry, E. K., Gibson, P. H., Blessed, G., Perry, R. H., & Tomlinson, B. E. (1977) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(77)90073-9 · Cited by 724
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“[36] Himmelheber AM, Sarter M, Bruno JP.”
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Event-related oscillations (ERO) during an active discrimination task: Effects of lesions of the nucleus basalis magnocellularis
Sánchez-Alavez, M., & Ehlers, C. L. (2015) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2015.02.010 · Cited by 11
“It has been shown that cortical acetylcholine (Ach) efflux increases during early stages of learning, when attentional processes are engaged for the identification and selection of relevant information in the environment, and during the formation of new stimulus associations (Acquas et al., 1996; Himmelheber et al., 2…”
Background
Models of Acetylcholine and Dopamine Signals Differentially Improve Neural Representations
Holca-Lamarre, R., Lücke, J., & Obermayer, K. (2017) · Frontiers in Computational Neuroscience · doi:10.3389/fncom.2017.00054 · Cited by 11
“In the course of such tasks, distractors that further tax the animals’ attentional systems trigger supplemental ACh release (Himmelheber et al., 2000; Kozak et al., 2006).”
Background
Relationship between the changes in M1 excitability after motor learning and arousal state as assessed by short-latency afferent inhibition
Koizume, Y., Hirano, M., Kubota, S., Tanaka, S., & Funase, K. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.05.037 · Cited by 11
“In a previous rat study, it was reported that the increase in the subjects’ arousal state was tightly linked to the increase in cortical ACh levels [16].”
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Pepeu, G., & Giovannini, M. G. (2006) · CRC Press eBooks · doi:10.1201/b14486-18 · Cited by 11
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Jacklin, D. L., Kelly, P., Bianchi, C., MacDonald, T., Traquair, H., & Winters, B. D. (2014) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2014.11.017 · Cited by 11
The consequences of atheoretical, task-driven experimentation: Theoretical comment on Paban, Chambon, Jaffard, and Alescio-Lautier (2005).
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Self-citation
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“…have demonstrated that cholinergic modulation depends on task difﬁculty (Bentley et al., 2004) and the level of attentional processes required to perform the task (Boucart et al., 2015), as ACh is more abundantly released in the case of high attentional demand (Himmelheber, Sarter, & Bruno, 2000).”
Volume Change in Frontal Cholinergic Structures After Traumatic Brain Injury and Cognitive Outcome
Östberg, A., Ledig, C., Katila, A. J., Maanpää, H.-R., Posti, J. P., Takala, R. S. K., Tallus, J., Glocker, B., Rueckert, D., & Tenovuo, O. S. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.00832 · Cited by 11
“Nevertheless, either preclinical and human studies have indicated that the cholinergic nuclei, especially in the basal forebrain region, have wide frontal cortical projections and are highly involved in attention maintenance (51, 54).”
Background
The neural basis of attentional alterations in prenatally protein malnourished rats
Rushmore, J., McGaughy, J. A., Amaral, A. C. S., Mokler, D. J., Morgane, P. J., Galler, J. R., & Rosene, D. L. (2020) · Cerebral Cortex · doi:10.1093/cercor/bhaa239 · Cited by 10
“, 1984) is necessary to facilitate detection of signal trials and to allow circuits to switch between signal and non-signal events (Himmelheber et al., 2000; Sarter et al., 2005).”
Background
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Hasegawa, M., & Wada, H. (2013) · Physiology & Behavior · doi:10.1016/j.physbeh.2013.02.019 · Cited by 10
Effects of Pro-Cholinergic Treatment in Patients Suffering from Spatial Neglect
Lucas, N., Saj̈, A., Schwartz, S., Ptak, R., Schnider, A., Thomas, C., Conne, P., Leroy, R., Pavin, S., Diserens, K., et al. (2013) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2013.00574 · Cited by 10
“ACH release in the cortex is increased both prior and during sustained attention demands, with further increase in response to distracters, presumably serving to enhance signal to noise of behaviorally relevant targets (Himmelheber et al., 2000; Klinkenberg et al., 2010).”
Background
Cholinergic enhancement differentially modulates neural response to encoding during face identity and face location working memory tasks
Handjaras, G., Ricciardi, E., Szczepanik, J. E., Pietrini, P., & Furey, M. L. (2013) · Experimental Biology and Medicine · doi:10.1177/1535370213497326 · Cited by 9
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Selective attenuation of Ether-a-go-go related K+ currents by endogenous acetylcholine reduces spike-frequency adaptation and network correlation
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Pupillometry as an objective measure of sustained attention in young and older listenersPreprint
Zhao, S., Bury, G., Milne, A. E., & Maria Chait, A. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/579540 · Cited by 9
α5 nAChR modulation of the prefrontal cortex makes attention resilient
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Effects of Anacyclus pyrethrum on affective behaviors and memory during withdrawal from cigarette smoke exposure in rats
Bezza, K., Laadraoui, J., Gabbas, Z. E., Laaradia, M. A., Oufquir, S., Aboufatima, R., Gharrassi, I., & Chait, A. (2020) · Pharmacognosy Magazine · doi:10.4103/pm.pm_279_19 · Cited by 8
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Demeter, E., Alburquerque, D. D., & Woldorff, M. G. (2016) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2016.06.038 · Cited by 8
“…about brain activity that is elicited during the dSAT, a translational attentional control paradigm that has been applied to both humans (Berry et al., 2015; Demeter et al., 2011, 2008) and animals (Gritton et al., 2016; Himmelheber et al., 2000; McGaughy and Sarter, 1995; St Peters et al., 2011a).”
Method
Serum antibodies targeting neurons of the monoaminergic systems in Guillain-Barré syndrome
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“Differing levels of effectiveness of novel AD treatments may result from timing of intervention and the level of neurological changes already set in motion by AD.”
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Mean field model of acetylcholine mediated dynamics in the cerebral cortex
Clearwater, J. M., RENNIE, C. J., & Robinson, P. A. (2007) · Biological Cybernetics · doi:10.1007/s00422-007-0186-9 · Cited by 7
“…system that projects to the cortex is implicated in a wide range of cognitive tasks and neurological disorders (Freo et al. 2002), and cholinergic neuromodulation is proposed as a key mechanism underlying attentional processing (Himmelheber et al. 2000; Rezvani and Levin 2001; Sarter et al. 2005).”
Background
Sensory adaptation in the barrel cortex during active sensation in the behaving mouse
Colins Rodriguez, A., Loft, M. S. E., Schiessl, I., Maravall, M., & Petersen, R. S. (2024) · Scientific Reports · doi:10.1038/s41598-024-70524-1 · Cited by 6
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A spatial covariance 123 I-5IA-85380 SPECT study of α4β2 nicotinic receptors in Alzheimer's disease
Colloby, S. J., Field, R. H., Wyper, D. J., O'Brien, J. T., & Taylor, J. (2016) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2016.07.017 · Cited by 6
“, 1982) and acetylcholine is central to a myriad of brain functions including learning and memory (Hasselmo, 2006), attention (Himmelheber et al., 2000; Klinkenberg et al., 2011), and the sleep-wake cycle (Lee et al.”
Background
Modeling cyclic variations in sustained human performance as measured by reaction time and the flash visual evoked potential-P2
Case, J. L., Arruda, J. E., & VanWormer, L. A. (2016) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2016.01.006 · Cited by 6
Mean field model of acetylcholine mediated dynamics in the thalamocortical system
Clearwater, J. M., RENNIE, C. J., & Robinson, P. A. (2008) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2008.08.010 · Cited by 6
“Cholinergic neuromodulation is a key mechanism underlying the maintenance of cortical activation, attentional processes (Himmelheber et al., 2000; Rezvani and Levin, 2001; Sarter et al., 2005), and mediation of the sleep/wake cycle (Steriade et al.”
Background
Behavioral and Biochemical Effects of an Arylhydrazone Derivative of 5-Methoxyindole-2-Carboxylic Acid in a Scopolamine-Induced Model of Alzheimer’s Type Dementia in Rats
Petkova-Kirova, P. S., Anastassova, N., Minchev, B., Uzunova, D. N., Grigorova, V., Tsvetanova, E. R., Georgieva, A. P., Alexandrova, A., Stefanova, M. O., Yancheva, D. Y., et al. (2024) · Molecules · doi:10.3390/molecules29235711 · Cited by 5
“ACh plays a fundamental role in memory formation and cognition, being central to essential processes such as attention [63,64], working memory [65,66], spatial learning and memory (for extensive review see [66,67], episodic memory [68,69], perceptual memory [70], cognitive flexibility [71], and…”
Orexins and Cognition: Neuroanatomical and Neurochemical Substrates
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Role of cholinergic-muscarinic receptors in visual discrimination performance of rats: Importance of stimulus load
Tsui, C. K. Y., & Dringenberg, H. C. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.10.005 · Cited by 5
Cholinergic Behavior State-Dependent Mechanisms of Neocortical Gain Control: a Neurocomputational Study
Puigbò, J.-Y., Maffei, G., Herreros, I., Ceresa, M., Ballester, M. Á. G., & Verschure, P. F. M. J. (2017) · Molecular Neurobiology · doi:10.1007/s12035-017-0737-6 · Cited by 5
In vitro anti-platelet aggregation activity of the extracts of bulbine natalensis
Lazarus, G. G. (2011) · Cited by 5
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Behavioral Pharmacology of Caffeine
Fenu, S., & Acquas, E. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-384937-3.00113-0 · Cited by 5
Activity of Neurons in the Basal Magnocellular Nucleus During Performance of an Operant Task
Chernyshev, B., Panasyuk, Y. A., Semikopnaia, I. I., & Timofeeva, N. O. (2004) · Neuroscience and Behavioral Physiology · doi:10.1023/b:neab.0000042575.79517.b6 · Cited by 4
“Microdialysis studies have demonstrated that performance by rats of attention-requiring tasks is accompanied by increased acetylcholine release into the cerebral cortex [ 28 ].”
Background

Authors: Himmelheber, A. M., Sarter, M., & Bruno, J. P.
Affiliations: The Ohio State University (US)
Corresponding author: Bruno, John P
ORCID: Sarter, Martin
Bruno, John P
Venue: Cognitive Brain Research
Publisher: Elsevier BV
Published: 2000-06
Volume: 9
Issue: 3
Pages: 313-325
ISSN: 0926-6410 (ISSN-L)
DOI: 10.1016/s0926-6410(00)00012-4
OpenAlex: W2063060972
Cited by: 261
References: 35
Citations by year: 2026: 3 · 2025: 4 · 2024: 3 · 2023: 4 · 2022: 5 · 2021: 3 · 2020: 13 · 2019: 11 · 2018: 13 · 2017: 10 · 2016: 9 · 2015: 11 · 2014: 17 · 2013: 13 · 2012: 13
FWCI: 3.88
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Cognitive Brain Research (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Mental Health (R01MH057436, MH57436)
National Institute of Neurological Disorders and Stroke (NS32938, NS37026, R01NS037026, R01NS032938)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Mind wandering and attention
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords: acetylcholine release, sustained attention, frontoparietal cortex, cholinergic neurotransmission, attentional effort, response bias, rats
MeSH terms: Acetylcholine, Animals, Attention, Cerebral Cortex, Conditioning, Operant, Habituation, Psychophysiologic, Male, Synaptic Transmission, Psychomotor Performance, Rats, Inbred F344, Prosencephalon, Microdialysis, Rats

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Increases in cortical acetylcholine release during sustained attention performance in rats

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