Differential cortical acetylcholine release in rats performing a sustained attention task versus behavioral control tasks that do not explicitly tax attention
Abstract
The present study used microdialysis techniques to compare acetylcholine release in the frontoparietal cortex of rats performing in a task requiring sustained attention with that of rats performing in two control procedures. The two control procedures were a fixed-interval 9-s schedule of reinforcement assessing primarily the effects of operant responding and comparable reward rates, and an operant procedure designed to test the effects of lever extension to prompt responding. These two control procedures involved comparable sensory-motor and motivational variables to those of the sustained attention task, but did not explicitly tax attentional processes. Performance of the sustained attention task was associated with a significant increase in cortical acetylcholine efflux, reaching a maximum of nearly 140%. Performance of the two control procedures was associated with significantly smaller (approximately 50%) increases in cortical acetylcholine release. This robust dissociation between attentional and control performance-associated increases in cortical acetylcholine release resulted, in part, from the elimination of the pre-task transfer of the animals into the operant chambers and the associated increases in acetylcholine release observed in previous studies. The present results support the hypothesis that demands on attentional performance, as opposed to the frequency of lever pressing, reward delivery and other task-related variables, selectively activate the basal forebrain corticopetal cholinergic system.
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Increases in ACh release are not observed in animals performing behavioral procedures that control for non-cognitive performance variables, such as lever pressing and reward rates, or the presentation of stimuli and distractors in contexts that do not require attention.
“These increases in ACh release were not observed in animals performing behavioral procedures that controlled for non-cognitive performance variables, such as lever pressing and reward rates, or the presentation of stimuli and distractors in contexts that do not require attention (e.g., Himmelheber et al, 1997; Arnold et al, 2002).”
From Modes and models of forebrain cholinergic neuromodulation of cognition (2011) · cites this paper as Arnold et al, 2002
Attentional performance-associated increases in cortical ACh release are consistently demonstrated by microdialysis.
“Measures of ACh release in task-performing animals, using microdialysis, consistently demonstrated attentional performance-associated increases in cortical ACh release.”
From Modes and models of forebrain cholinergic neuromodulation of cognition (2011) · cites this paper as Arnold et al, 2002
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Self-citation
- Authors
- Arnold, H. M., Burk, J. A., Hodgson, E. M., Sarter, M., & Bruno, J. P.
- Affiliations
- The Ohio State University (US)
- Corresponding author
- Bruno, J.P
- Venue
- Neuroscience
- Publisher
- Elsevier BV
- Published
- 2002-10
- Volume
- 114
- Issue
- 2
- Pages
- 451-460
- ISSN
- 0306-4522 (ISSN-L)
- OpenAlex
- W2096253586
- Cited by
- 195
- References
- 36
- Citations by year
- 2026: 6 · 2025: 4 · 2024: 7 · 2023: 5 · 2022: 1 · 2021: 1 · 2020: 6 · 2019: 7 · 2018: 6 · 2017: 11 · 2016: 5 · 2015: 3 · 2014: 7 · 2013: 10 · 2012: 14
- FWCI
- 4.07
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (R01MH057436, MH57436)
- National Institute of Neurological Disorders and Stroke (NS37026, R01NS037026)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Mind wandering and attention
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- acetylcholine release, sustained attention, frontoparietal cortex, cholinergic system, attentional demands, operant responding, fixed-interval schedules, basal forebrain, rats
- MeSH terms
- Acetylcholine, Animals, Attention, Behavior, Animal, Cerebral Cortex, Cholinergic Fibers, Conditioning, Operant, Male, Neural Pathways, Neuropsychological Tests, Psychomotor Performance, Rats, Inbred F344, Up-Regulation, Microdialysis, Presynaptic Terminals, Basal Nucleus of Meynert, Rats
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