The DOI matches its Crossref record; 19 of the 20 references it cites were found in a registry or an index.
Oral probiotics can resolve urogenital infections
Open accessAbstract
We report the first clinical evidence that probiotic lactobacilli can be delivered to the vagina following oral intake. In 10 women with a history of recurrent yeast vaginitis, bacterial vaginosis (BV) and urinary tract infections, strains Lactobacillus rhamnosus GR-1 and Lactobacillus fermentum RC-14 suspended in skim milk and given twice daily for 14 days, were recovered from the vagina and identified by morphology and molecular typing within 1 week of commencement of therapy. In six cases of asymptomatic BV or intermediate BV (based upon Nugent scoring) was resolved within 1 week of therapy.
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“Evidence supports the translocation of gastrointestinal Lactobacillus strains to the vagina (gut-vagina axis), suggesting that oral probiotic intake may be directly linked with improved vaginal microbiota balance and local immune responses [55].”
From Women's health is a team effort: probiogenomics supports the development of a multi-species vaginal probiotic (2026) · cites this paper as [55]
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HIV-1 infection associated with abnormal vaginal flora morphology and bacterial vaginosis
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The Scientific Basis for Probiotic Strains of Lactobacillus
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Heinemann, C., Vlieg, J. E. T. V. H., Janssen, D. B., Busscher, H. J., van der Mei, H. C., & Reid, G. (2000) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2000.tb09282.x · Cited by 189
Self-citationSelection ofLactobacillusStrains for Urogenital Probiotic Applications
Reid, G., & Bruce, A. W. (2001) · The Journal of Infectious Diseases · doi:10.1086/318841 · Cited by 160
Self-citationDifferentiation of Lactobacillus Species by Molecular Typing
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Research works printed but not linked: 2
- [4] Felmingham, D. (2000) Changing resistance patterns: European perspective. International Symposium on Trends and Perspectives in the Management of Urinary Tract Infection, Orlando, FL, March 10.
- Reid, 1995, Instillation of Lactobacillus and stimulation of indigenous organisms to prevent recurrence of urinary tract infections, Microecol. Ther., 23, 32
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Metadata
- Authors
- Reid, G., Bruce, A. W., Fraser, N., Heinemann, C., Owen, J., & Henning, B.
- Affiliations
- Western University (CA)
- Lawson Research Institute (CA)
- Corresponding author
- Reid, Gregor
- ORCID
- Reid, Gregor
- Venue
- FEMS Immunology & Medical Microbiology
- Publisher
- Oxford University Press (OUP)
- Published
- 2001-02
- Volume
- 30
- Issue
- 1
- Pages
- 49-52
- ISSN
- 0928-8244 (ISSN-L)
- 1574-695X
- OpenAlex
- W2130187365
- Cited by
- 464
- References
- 20
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 14 · 2023: 32 · 2022: 19 · 2021: 24 · 2020: 15 · 2019: 19 · 2018: 12 · 2017: 22 · 2016: 22 · 2015: 14 · 2014: 27 · 2013: 33 · 2012: 24
- FWCI
- 30.50
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- FEMS Immunology & Medical Microbiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
- Health Sciences › Medicine › Urology › Urinary Tract Infections Management
- Keywords
- oral probiotics, vaginal lactobacilli, Lactobacillus rhamnosus GR-1, bacterial vaginosis, urinary tract infection, urogenital infections, Nugent score
- MeSH terms
- Administration, Oral, Bacterial Infections, Female, Humans, Lactobacillus, Vagina, Probiotics, Female Urogenital Diseases
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